Specificity of Biogenic Selenium Nanoparticles for Prostate Cancer Therapy With Reduced Risk of Toxicity: An in vitro and in vivo Study

Sonkusre, Praveen

doi:10.3389/fonc.2019.01541

Cited by 52 publications

(39 citation statements)

References 32 publications

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“…As opposed to conventional chemogenic syntheses, biogenic approaches give rise to thermodynamically stable yet structurally diverse SeNS products in a safe and eco-friendly manner, avoiding the need of post-production treatments [2]. To date, biogenic SeNMs were investigated for their applications in (i) biomedicine, as antimicrobial [19][20][21][22][23][24][25][26][27], anticancer [27][28][29][30][31][32][33][34][35][36][37][38] and antioxidant [27,[39][40][41] agents, due to their high biocompatibility towards eukaryotic in vitro and in vivo systems [22,28,40,42], (ii) photocatalysis, and (iii) biosensing or pollutant adsorption [43][44][45][46], leaving still unveiled the potentiality of these NSs as a bioimaging tool. In particular, the PL properties of SeNPs produced by bacteria just recently began to be explored, as in the case of those recovered from the environmental isolate Stenotrophomonas maltophilia SeITE02 under metabolically controlled growth conditions [6].…”

Section: Introductionmentioning

confidence: 99%

Tunable photoluminescence properties of selenium nanoparticles: biogenic versus chemogenic synthesis

et al. 2020

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AbstractVarious technological and biomedical applications rely on the ability of materials to emit light (photoluminescence [PL]), and, among them, metal nanoparticles (NPs) and semi-conductor Quantum Dots (QDs) represent ideal candidates as sensing probes and imaging tools, portraying better PL features than conventional organic dyes. However, the knowledge of PL behavior of semiconductor NPs – i.e., selenium; SeNPs – is still in its infancy, especially for those synthesized by microorganisms. Considering the essential role played by biogenic SeNPs as antimicrobial, anticancer, and antioxidant agents, or food supplements, their PL properties must be explored to take full advantage of them as eco-friendly and versatile tools. Here, PL features of SeNPs produced by the Se-tolerant Stenotrophomonas maltophilia SeITE02 strain, compared with chemogenic ones, are investigated, highlighting the PL dependency on the NP size. Indeed, PL emission shifted from indigo-blue (emission wavelength λem 400–450 nm) to green-yellow (λem 480–570 nm) and orange-red (λem 580–700 nm) for small (ca. 50 nm) and big (ca. 100 nm) SeNPs respectively, revealing the versatility of an environmental bacterial isolate to synthesize diverse PL probes. Besides, biogenic SeNPs show PL lifetime comparable to those of the most used fluorophores, supporting their potential application as markers for (bio)imaging.

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Section: Introductionmentioning

confidence: 99%

Tunable photoluminescence properties of selenium nanoparticles: biogenic versus chemogenic synthesis

et al. 2020

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“…The nutritional content of the diet and the relationship between the nutrients and PCa risk is still unclear [52]. Specifically, with respect to selenium, there are studies that find a link with the PCa, pointing out an anti-inflammatory effect of supplemental selenium as a possible causal pathway [53,54]. Similarly, the Nutritional Prevention of Cancer Trial, originally developed to study the effect of selenium on non-melanoma skin cancer, found a 63% reduction in PCa risk among men taking selenium supplements [55].…”

Section: Discussionmentioning

confidence: 99%

Dietary Diversity and Prostate Cancer in a Spanish Adult Population: CAPLIFE Study

et al. 2020

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Dietary diversity (DD) is a key component of a high-quality diet, providing the adequate nutrient requirements. However, the role of DD on prostate cancer (PCa) is still uncertain. The aim of this study was to evaluate the relationship between DD, adequate nutrient intake and PCa, according to the aggressiveness of the tumor. The CAPLIFE (CAP: prostate cancer; LIFE: lifestyles) study is a population-based case-control study including a total of 402 incident PCa cases and 302 controls. The DD score (DDS), adjusted by total energy intake, was collected through a validated food frequency questionnaire. Nutrient adequacy was defined according to European Dietary Recommendation Intake for men. The aggressiveness of PCa was determined according to the International Society of Urology Pathology classification. The association between DDS, nutrient intake and PCa was assessed by logistic regression models with adjustment for potential confounding factors. DDS was similar for PCa cases and controls, independent of PCa aggressiveness. According to each food group DDS, the protein group showed the highest mean score in all the subgroups analyzed. However, no differences were observed for each of the DDS components. The DDS, the variety of the group’s food intake, and the adequate nutrient intake, were not associated with PCa.

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“…SW30, [ 89 ] Bacillus pumilus sp. BAB‐3706, [ 90 ] Pseudomonas putida KT2440, [ 85 ] Azospirillum brasilense , [ 91 ] Bacillus licheniformis , [ 35 ] Vibrio natriegens , [ 92 ] Rhodococcus aetherivorans , [ 80 ] Pseudomonas alcaliphila , [ 93 ] Alcaligenes faecalis , [ 94 ] Pseudomonas stutzeri [ 95 ] and, more recently, Bacillus amyloliquefaciens SRB04, which has been shown to produce SeNPs smaller than 50 nm. [ 75 ]…”

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

234

146

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Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se‐based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug‐loaded SeNP to tumor sites, thus avoiding off‐target effects.

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Specificity of Biogenic Selenium Nanoparticles for Prostate Cancer Therapy With Reduced Risk of Toxicity: An in vitro and in vivo Study

Cited by 52 publications

References 32 publications

Tunable photoluminescence properties of selenium nanoparticles: biogenic versus chemogenic synthesis

Tunable photoluminescence properties of selenium nanoparticles: biogenic versus chemogenic synthesis

Dietary Diversity and Prostate Cancer in a Spanish Adult Population: CAPLIFE Study

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

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