Specificity of associations between parental psychopathology and offspring brain structure

Mattoni, Matthew; Hopman, Helene; Dadematthews, Adefunke; Chan, Sandra S. M.; Olino, Thomas M.

doi:10.1016/j.pscychresns.2023.111684

Cited by 2 publications

(2 citation statements)

References 43 publications

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“…ABCD Study findings have revealed smaller volume in the right putamen (Pagliaccio et al, 2020), left hippocampus (Chen et al, 2010), and bilateral hippocampi (Rao et al, 2010), aligning with our results. However, studies using other datasets have found that parental history of depression is associated with larger volume in the bilateral amygdala (Lupien et al, 2011), and others have reported no effects (Mattoni et al, 2023). ELA dimensions that indicated the potential presence of household hostility including family aggression (e.g., throwing things, hitting) (F8) revealed a positive main effect for fMRI BAG, but no effects for family arguments (e.g., expressing anger, fighting, raising voices) (F7), with the latter finding going against our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

“…These findings reflect age patterns of hippocampi and putamen usually not seen until late adolescents and young adulthood – whereby subcortical volumes are expected to reduce over time (82,83) – suggesting the results may indicate accelerated ageing in this younger sample, and thus aligning with the directionality of our results. However, studies using other datasets have found that parental history of depression is associated with larger volume in the bilateral amygdala (84), and others have reported no effects (85). ELA dimensions that indicated the potential presence of household hostility including family aggression (e.g., throwing things, hitting) (F8) revealed a positive main effect for rs-fMRI BAG, but no effects for family arguments (e.g., expressing anger, fighting, raising voices) (F7), with the latter finding going against our hypothesis.…”

Section: Discussionmentioning

confidence: 99%

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Dimensions of early life adversity are differentially associated with patterns of delayed and accelerated brain maturation

Beck,

Whitmore,

MacSweeney

et al. 2024

Preprint

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Different types of early-life adversity have been associated with children’s brain structure and function. However, understanding the disparate influence of distinct adversity exposures on the developing brain remains a major challenge. This study investigates the neural correlates of 10 robust dimensions of early-life adversity identified through exploratory factor analysis in a large community sample of youth from the Adolescent Brain Cognitive Development (ABCD) Study. Brain age models were trained, validated, and tested separately on T1- weighted (T1; N = 9524), diffusion tensor (DTI; N = 8834), and resting-state functional (rs- fMRI; N = 8233) magnetic resonance imaging (MRI) data from two time points (mean age = 10.7 years, SD = 1.2, range = 8.9-13.8 years). Bayesian multilevel modelling supported distinct associations between different types of early-life adversity exposures and younger- and older-looking brains. Dimensions generally related to emotional neglect, such as lack of primary and secondary caregiver support, and lack of caregiver supervision, were associated with lower brain age gaps (BAGs), i.e., younger-looking brains. In contrast, dimensions generally related to caregiver psychopathology, trauma exposure, family aggression, substance use and separation from biological parent, and socio-economic disadvantage and neighbourhood safety were associated with higher BAGs, i.e., older-looking brains. The findings suggest that dimensions of early-life adversity are differentially associated with distinct neurodevelopmental patterns, indicative of dimension-specific delayed and accelerated brain maturation.

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