Specificity models in <scp>MAPK</scp> cascade signaling

Ma, Yi; Nicolet, Joël

doi:10.1002/2211-5463.13619

Cited by 13 publications

(4 citation statements)

References 120 publications

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“…Mitogen-activated protein kinase (MAPK) is a group of serine/threonine protein kinases that can be activated by different extracellular stimulation. It is involved in many biological processes such as apoptosis, hormone signal transduction, and the regulation of inflammatory factors [113]. It has been confirmed that MAPK genes can be divided into three major subfamilies, namely extracellular-signal-regulated kinases (ERKs), the p38 MAPKs, and Jun N-terminal kinases (JNKs) [114].…”

Section: Mapk Signaling Pathwaymentioning

confidence: 99%

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

Wang,

Xu,

Yan

et al. 2024

Biomedicines

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Ischemia reperfusion (I/R) is a common pathological process which occurs mostly in organs like the heart, brain, kidney, and lung. The injury caused by I/R gradually becomes one of the main causes of fatal diseases, which is an urgent clinical problem to be solved. Although great progress has been made in therapeutic methods, including surgical, drug, gene therapy, and transplant therapy for I/R injury, the development of effective methods to cure the injury remains a worldwide challenge. In recent years, exosomes have attracted much attention for their important roles in immune response, antigen presentation, cell migration, cell differentiation, and tumor invasion. Meanwhile, exosomes have been shown to have great potential in the treatment of I/R injury in organs. The study of the exosome-mediated signaling pathway can not only help to reveal the mechanism behind exosomes promoting reperfusion injury recovery, but also provide a theoretical basis for the clinical application of exosomes. Here, we review the research progress in utilizing various exosomes from different cell types to promote the healing of I/R injury, focusing on the classical signaling pathways such as PI3K/Akt, NF-κB, Nrf2, PTEN, Wnt, MAPK, toll-like receptor, and AMPK. The results suggest that exosomes regulate these signaling pathways to reduce oxidative stress, regulate immune responses, decrease the expression of inflammatory cytokines, and promote tissue repair, making exosomes a competitive emerging vector for treating I/R damage in organs.

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Section: Mapk Signaling Pathwaymentioning

confidence: 99%

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

Wang,

Xu,

Yan

et al. 2024

Biomedicines

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“…MAP kinases (MAPKs) represent the terminal components of the cascade, which are activated by dual phosphorylation on conserved threonine and tyrosine residues in the TxY motif of the activation loop (Jonak et al, 2002). These kinases function as molecular switches that turn on the expression of specific sets of genes, resulting in the activation of cellular responses (Ma and Nicolet, 2023).…”

Section: Introductionmentioning

confidence: 99%

MAPK activity and MAP kinase phosphatase 2 (AtMKP2) protein stability under altered glutathione homeostasis inArabidopsis thaliana

Yang,

Matern,

Steininger

et al. 2024

Preprint

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Mitogen-activated protein kinases (MAPKs) are important signaling players involved in various responses to diverse environmental stresses. MAP kinase phosphatases (MKPs) are crucial negative regulators of MAPKs and control the intensity and duration of MAPK activation. It has been shown that transgenic tobacco plants with increased glutathione content display an oxidative shift and have constitutively active immunity-related MAPKs. The mechanism by which glutathione can activate or keep these MAPKs in activated state is unclear. In this study, it is shown that theArabidopsisstress-related MAPKs, AtMPK3 and AtMPK6 are hypersensitive to a pathogen-associated molecular pattern flg22 in thecat2-1line, under the conditions causing an altered glutathione homeostasis and elevated oxidative stress responses in this background. As AtMKP2 is the only dual specificity phosphatase deactivating AtMPK3 and AtMPK6 in response to oxidative stress, the stability of the wild-type AtMKP2 protein and the mutant version of the protein with the substitution of the cys109 in the active site with serine has been studied in wild type (Col-0) andcat2-1background. The results indicate that AtMKP2 is a stable protein in both genetic backgrounds, whereas the active site cys109 stabilizes the protein under severe oxidative stress conditions and can be glutathionylatedin vitro.

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“…Over the course of evolution, there was a rapid expansion in the number of RLKs from lower to higher plants (Shiu et al 2003); however, the number of downstream components such as MAPK components did not increase correspondingly (Xu and Zhang 2015). Recently, a crucial question in biology is how MAPKcascades regulate different outputs with speci city (Ma et al 2023).…”

Section: Introductionmentioning

confidence: 99%

Characterization and expression analysis of two mitogen-activated protein kinase kinase kinase genes from Antarctic moss Pohlia nutans

Liu

Kong

et al. 2023

Preprint

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Mitogen activated protein kinase (MAPK) signaling plays essential roles in plant growth, development and responses to environmental stresses. However, only limited information is available on the MAPK signaling genes in the bryophytes. Two full-length of mitogen-activated protein kinase kinase kinase genes (designated as PnMEKK1 and PnMEKK2) were identified from Antarctic moss Pohlia nutans. The full length cDNA of PnMEKK1 and PnMEKK2 were 3012 bp and 3096 bp, encoding the receptor-like kinases of 804 and 576 amino acids, respectively. Multiple sequence alignment showed that PnMEKK1 and PnMEKK2 possessed the conserved STKc_MAP3K-like domains, but they had relatively low identities with other protein kinases. Phylogenetic analysis showed that they clustered together with the protein kinases of ferns and mosses but not higher plants. In addition, the subcellular localization analysis by observing the transient expression of PnMEKK-green fluorescence protein in Arabidopsis mesophyll protoplasts revealed that PnMEKK1 and PnMEKK2 were cytoplasm-localized protein kinases. Meanwhile, the mRNA expression profile of PnMEKK1 and PnMEKK2 were quantified by quantitative RT-PCR. Results showed that cold, salinity, drought and UV-B radiation could motivate the up-regulation of PnMEKK1 and PnMEKK2 mRNA expression. In addition, the application of plant hormone abscisic acid (ABA) and methyl jasmonate (MeJA) also could up-regulate the mRNA expression level. Taken together, we purposed that these two isolated PnMEKKs might involve in Antarctic mosses Pohlia nutans adapting to the polar extreme environments.

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Specificity models in MAPK cascade signaling

Cited by 13 publications

References 120 publications

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

Exosomes-Mediated Signaling Pathway: A New Direction for Treatment of Organ Ischemia-Reperfusion Injury

MAPK activity and MAP kinase phosphatase 2 (AtMKP2) protein stability under altered glutathione homeostasis inArabidopsis thaliana

Characterization and expression analysis of two mitogen-activated protein kinase kinase kinase genes from Antarctic moss Pohlia nutans

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