Specificity in the correlation of verbal memory and hippocampal neuron loss: Dissociation of memory, language, and verbal intellectual ability

Sass, Kimberlee J.; Sass, A.; Westerveld, Michael; Lencz, Todd; Novelly, Robert A.; Kim, J. H.; Spencer, Dennis D.

doi:10.1080/01688639208402854

Cited by 153 publications

(102 citation statements)

References 12 publications

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“…In patients with left MTLE, preoperative verbal memory deficit has been correlated with cell loss in CA3 (73). In many patients, the memory deficit affects both visual and verbal function, further support for the emerging concept of MTLE as a bilateral process.…”

Section: Developmental Acquired Medial Temporal Lobe Epilepsy Localmentioning

confidence: 68%

Substrates of Localization‐Related Epilepsies: Biologic Implications of Localizing Findings in Humans

Spencer

1998

Epilepsia

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Section: Developmental Acquired Medial Temporal Lobe Epilepsy Localmentioning

confidence: 68%

Substrates of Localization‐Related Epilepsies: Biologic Implications of Localizing Findings in Humans

Spencer

1998

Epilepsia

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“…Furthermore, these findings may have relevance for pre-post surgical outcome in cognition. The focus of much of the surgical outcome literature has emphasized the integrity of the resected hippocampus for memory outcome (Chelune, 1995;Sass et al, 1992). Our findings suggest that cognitive variability in surgical outcome may also be related to thalamic integrity before and0or after surgery.…”

Section: Cognitive Functioningmentioning

confidence: 74%

Thalamic atrophy and cognition in unilateral temporal lobe epilepsy

Seidenberg

Hermann

Pulsipher

et al. 2008

J Inter Neuropsych Soc

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This study examined quantitative magnetic resonance volumes of the thalamus and hippocampus and determined their relationship with cognitive function and clinical seizure characteristics in a sample of 46 unilateral temporal lobe epilepsy (TLE) subjects (20 left and 26 right) and 29 controls. The hippocampus and thalamus exhibited different patterns of volume abnormality, different associations with clinical seizure characteristics, and different patterns of relationship with cognitive measures. Hippocampal volume reduction was primarily ipsilateral to the seizure focus, and thalamic volume reduction was bilateral. Ipsilateral hippocampal volume was significantly correlated with both early neurodevelopmental features (age of seizure onset) and disease characteristics (duration of epilepsy), whereas thalamus integrity was related only to disease variables. Hippocampal volume showed a selective association with verbal memory performance. In contrast, both left and right thalamic volumes were significantly correlated with performance on both memory and nonmemory cognitive domains. These findings underscore the importance of thalamic atrophy in chronic TLE and its potential implications for cognition. (JINS, 2008, 14, 384-393.)

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“…However, in patients with left TLE, Lencz et al (36) reported a significant correlation between MRI estimates of lesion size in the left hippocampus and the Wechsler logical memory scores, which assess recall abilities. Likewise, Rausch and Babb (37) and Sass et al (38) reported a significant correlation between the Wechsler logical memory scores and the neuron density in the hippocampus in their histologic specimens, suggesting that hippocampal function may be involved in recall. Hermann et al (39) found that patients with mesial TLE were more impaired on both recall and learning tests than were patients without mesial TLE.…”

Section: Discussionmentioning

confidence: 89%

Learning and Memory Impairment in Patients with Temporal Lobe Epilepsy: Relation to the Presence, Type, and Location of Brain Lesion

Giovagnoli¹,

Avanzini²

1999

Epilepsia

119

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Summary:Purpose: To study the influence of epileptogenic lesions on learning and memory alterations in patients with temporal lobe epilepsy (TLE).Methods: We studied 131 patients (55 with left and 39 with right lesional TLE; 22 with left and 15 with right cryptogenic TLE) and 36 healthy subjects. We compared these groups by using a battery of tests to assess verbal and visual learning, delayed recall, and recall after the imposition of interfering activity.Results: Compared with the controls and patients with right TLE, the patients with left TLE were significantly impaired on all verbal tests. On visual tests, patients with right TLE were impaired compared with controls but not more so than patients with left TLE. Separate multivariate analyses of variance (MA-NOVAS) of patients' verbal and visual test scores, taking the TLE side and morphologic features of the temporal lobes (i.e., normal, hippocampal sclerosis, low-grade glioma, or cavernous angioma) as independent factors, did not show any significant effect of these features. Separate comparisons of verbal and visual test scores of patients with lesional TLE, taking the side and location (mesial or lateral) of the epileptogenic lesion as independent factors, did not show any significant effect of location.Conclusions: Our findings show that some learning and memory abilities are impaired in patients with TLE irrespective of the presence of overt damage. This supports the theory that focal epileptic discharges, rather than the lesions themselves, affect these functions. The pathologic characteristics and intratemporal location of an associated lesion do not seem to play an important role in determining learning and memory impairment when clinical and treatment-related factors are taken into account. Key Words: Temporal lobe epilepsy-LesionLearning-Memory .Learning and memory difficulties are the most frequent cognitive alterations in patients with temporal lobe epilepsy (TLE) (1). Memory abilities in TLE are influenced by the presence of interictal epileptic discharges not associated with overt seizures (2), age at seizure onset, disease duration, seizure frequency (3), anxiety, depression (4), and antiepileptic drug (AED) treatment (5). However, the role of focal brain lesions (as distinct from focal epileptic discharges) has not been clearly established.Deutsch (6) found that patients with epilepsy with and without overt brain damage were similarly impaired on learning and memory tests, whereas Klove and Matthews (7) reported worse performances in patients with lesional

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Specificity in the correlation of verbal memory and hippocampal neuron loss: Dissociation of memory, language, and verbal intellectual ability

Cited by 153 publications

References 12 publications

Substrates of Localization‐Related Epilepsies: Biologic Implications of Localizing Findings in Humans

Substrates of Localization‐Related Epilepsies: Biologic Implications of Localizing Findings in Humans

Thalamic atrophy and cognition in unilateral temporal lobe epilepsy

Learning and Memory Impairment in Patients with Temporal Lobe Epilepsy: Relation to the Presence, Type, and Location of Brain Lesion

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