Specificity and Properties of Propofol as an Antioxidant Free Radical Scavenger

Bennett, S; Nelson, Valery

doi:10.1006/taap.1994.1240

Cited by 149 publications

(68 citation statements)

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“…SOD is another enzyme searched for its antioxidising effect. Green et al reported that [25] propofol has no effect on SOD however in our study we found the increase in SOD level statistically significant in Propofol Group when compared to I/R Group. This results shows us that propofol has a positive effect on SOD levels thus to reduce the superoxide radicals to H 2 O 2 spends more than normal SOD which leads to decrease in SOD levels.…”

Section: Discussioncontrasting

confidence: 69%

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Urfalıoğlu¹,

Cantürk²,

Akçaboy³

et al. 2013

J Anesthe Clinic Res

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Surgical procedureAnesthesia was induced with Ketamine to rats, (Ketalar flk, Eczacıbaşı) with a dose of 90 mg/kg. Under sterile cover, laporatomy was performed via midline incision. Hepatoduodenal ligament was Materials and methods: 24 rats were randomly divided into four groups. Following anesthesia laparotomy was done and hepatoduodenal ligament was explorated. Tissue samples were taken for both biochemical (MDA, SOD, GPx) and histological study.Results: MDA level was hisghest in Group II and was significantly lower in Group III and Group IV. GPx level was lowest in Group II, the level of GPx was higher in Group III and Group IV with respect to Group II. SOD level was lowest in Group II and was highest in Group IV. SOD levels in Group II and Group III did not show statistical significance. In the histopathological study, in Group I the liver parenchyme and membrane integrity was protected; in Group II the hepatocyte cellular membrane integrity was distorted, microvesicule number increased and the liver sinusoids were shrunken; in Group III the hepatocyte membrane and nucleus was near normal and well protected; and in Group IV the cellular component structures were protected, hepatocyte cell membrane was protected in normal thickness. Discussion:The results show that dexmedetomidine and propofol decrease the level of MDA in similarly; the effect of dexmedetomidine on GPx level was slightly lower than propofol and its effect on SOD level was lower than propofol. As a result, we believe that either propofol or dexmedetomidine can be effective in protecting hepatocytes from I/R injury especially in log term procedures but the former drug having dominance in this protective role.

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Section: Discussioncontrasting

confidence: 69%

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Urfalıoğlu¹,

Cantürk²,

Akçaboy³

et al. 2013

J Anesthe Clinic Res

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“…al At concentrations of 10-30/ag.m1-1, propofol preferentially scavenges organoradical species. 4 Given its antioxidant potential, it seems likely that propofol could modify the extent of myocardial IRI. Functionally, enhancing red cell antioxidant capacity with propofol may serve to increase the threshold at which tissue injury would occur.…”

Section: Discussionmentioning

confidence: 99%

Propofol enhances red cell antioxidant capacity in swine and humans

et al. 1998

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Propofol enhances red cell antioxidant capacity in swine and humansPurpose: To determine the effect of an anaesthetic with antioxidant potential, propofol, on red blood cell (RBC) antioxidant enzyme activities and RBC susceptibility to peroxidative challenge. Methods: Propofol was administered by intravenous bolus (2.5 mg.kg -~) and continuous infusion (36 and 72 ml'hr -J in nine swine; 216 ml-hr "-~ in two swine), to achieve serum concentrations between 5 and 30/Jg.ml -~ for two hours at each rate. Arterial blood sampling was at 0,10, 30, 60, and 120 min for each rate of infusion, for measurement of plasma propofol concentration, activities of plasma and RBC superoxide dismutase, glutathione peroxidase, gluthathione reductase, RBC catalase, and RBC malondialdehyde (MDA) formation in response to ex vivo oxidative challenge with t-butyl hydrogen peroxide (tBHP; I .SmM). Antioxidant mechanisms were determined by in vitro study of MDA formation, GSH depletion, and oxidation of haemoglobin to methaemogl0bin in human erythrocytes exposed to propofol 0-75/uM. The antioxidant potential of propofol was Compared with that of alpha-tocopherol utilising the reaction with 2,4,6-tripyridyl-s-triazine (TPTZ). Results: Propofol had no effect on plasma or RBC antioxidant enzyme activities. It inhibited RBC MDA production over the range of 0-20/ug.ml -~ (y = -I 8.683x + 85.431; R 2 = 0.8174). Effective propofol concentrations for 25% and 50% reductions in MDA levels were 7-12 and 12-20/ug.ml -t, respectively. Propofol has a similar effect on human erythrocytes in vitro (R 2 = 0.98). Conclusion" Propofol antagonises the effects of forced peroxidation of red cells at anaesthetic and sub-anaesthetic concentrations in swine. Its actions include scavenging of oxygen derived free radicals in a tocopherol-like manner.Objectif : D&erminer I'effet d'un agent anesth&ique poss~dant un potentiel antioxydant, le propofol, sur I'activit~ d'un enzyme antioxydant des globules rouges (GR) et sur la susceptibilit~ des GR ~ une provocation peroxydative. M&hodes : Le propofol a ~t~ administr~ en bolus intraveineux (2,5 mg'kg -I) et en infusions continues (36 et 72 ml.h -~ chez 9 porcs; 216 ml'h -~ chez 2 porcs) pour obtenir des concentrations s&iques entre 5 et 30/ug'mff durant deux heures ~. chaque vitesse d'infusion. Des pr~l~vements sanguins par voie art&ielle ont ~t~ r~alis& ~ 0, 10, 30, 60 et 120 min. pour chaque vitesse d'infusion; on a mesur~ la concent~tion de propofol, I'activit~ de la superoxyde dismutase du plasma et des GR, de la peroxydase du glutathion, de la r~ductase du glutathion, de la catalase du GR, ainsi que de la formation dans le GR de la malondialdehyde (MDA) en r~ponse ~ une provocation oxydative ex vivo avec le peroxyde d'hydrog~ne t-butylique (tBHP, 1,5 mM). Les m&anismes antioxydants ont &~ d~termin& par I'& tude in vitro de la formation de MDA, de la d~pl&ion de GSH ainsi que de I'oxydation de I'h~mogl0bine en meth& moglobine dans des GR humains expos& au propofol 0-75/~M. Le potentiel antioxydant du propofol a ~t~ comp...

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“…gia, intra-abdominal infection, and/or postoperative mortality. It is notable that in this study, all animals survived with a functioning aortic bypass, regardless of group allocation, and were healthy after seven days Several studies have demonstrated the antioxidant properties of propofol in both in vivo and in vitro models, [5][6][7] suggesting the potential benefit of the drug as an antioxidant in situations of IR that lead to SIR. Other investigators have also reported that, in vivo, propofol increases the antioxidant capacity of erythrocytes, 2,20 decreases lipid peroxidation and preserves myocardial contractile function, 21 while appearing to decrease OFR production.…”

Section: Discussionmentioning

confidence: 76%

“…[1][2][3] Recently, it has been reported that anesthetic agents may offer some protection against such lesions induced by IR, and hence knowledge of the mechanisms involved may provide anesthesiologists with strategies to lower morbidity and improve patient survival. 4 Propofol, a highly lipid soluble hypnotic agent, has proven antioxidant activity in both in vitro and in vivo studies; this is based on the fact that its chemical structure is similar to that of a natural antioxidant: i.e., vitamin E. [5][6][7] In this sense, several studies have demonstrated that propofol acts as a scavenger of oxygen free radicals, decreasing lipid peroxidation and increasing the antioxidant capacity of erythrocytes and other tissues in organs such as liver, kidney, heart and lung. 8,9 Other studies that have shown that volatile anesthetics exert a protective role in different organs when they are administered before and after ischemia.…”

mentioning

confidence: 99%

Laboratory investigation: Effects of propofol on the systemic inflammatory response during aortic surgery

Rodríguez-López

Conde

Lozano

et al. 2006

Can J Anesth/J Can Anesth

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Purpose: A laboratory investigation was undertaken to assess the effects of propofol on renal function, through modulation of the systemic inflammatory response, in an in vivo experimental model of aortic surgery in comparison with sevoflurane.Methods: Twenty young male piglets were anesthetized with either propofol 4 mg·kg -1 ·hr -1 (n = 10) or sevoflurane 1.5% end-tidal concentration (n = 10). Animals were subjected to aorta-aortic bypass with suprarenal aortic clamping for 30 min. At specific intervals (basal -before the start of surgery; reperfusion 15 min after unclamping the aorta; at 24, 48 and 72 hr after surgery, and on the seventh day after surgery) the levels of the following were determined: plasma creatinine, renal myeloperoxidase, tumour necrosis factor-α, interleukin 1-ß, and interferon-γ; kidney superoxide anion and its detoxifying enzyme superoxidase dismutase, kidney malondialdehyde and the activity of inducible nitric oxide synthase. Seven days after surgery, the animals were anesthetized using the described techniques, and after blood withdrawal and kidney sampling they were sacrificed. Results:In comparison with sevoflurane, propofol was associated with a lower concentration of plasma creatinine (P < 0.05) together with lower concentrations of myeloperoxidase, tumour necrosis factor-α, interleukin 1-ß, interferon-γ, superoxide anion and superoxidase dismutase, malondialdehyde and inducible nitric oxide synthase (P < 0.05). Conclusion:In an experimental model of aortic reconstructive surgery, and compared with sevoflurane, propofol anesthesia is associated with less neutrophil infiltration, lower plasma proinflammatory cytokine levels, lower production of oxygen free radicals, less lipid peroxidation, and reduced inducible nitric oxide synthase activity. These observations suggest a possible renal protective effect of propofol in this surgical setting. Objectif

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Specificity and Properties of Propofol as an Antioxidant Free Radical Scavenger

Cited by 149 publications

References 0 publications

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

The Effect of Dexmedetomidine and Propofol on Oxidative Stress and Antioxidizing System Studied on Liver Ischemia-reperfusion Model on Rats

Propofol enhances red cell antioxidant capacity in swine and humans

Laboratory investigation: Effects of propofol on the systemic inflammatory response during aortic surgery

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