2004
DOI: 10.1038/sj.bjc.6602257
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Specificity and heregulin regulation of Ebp1 (ErbB3 binding protein 1) mediated repression of androgen receptor signalling

Abstract: Although ErbB receptors have been implicated in the progression of prostate cancer, little is known about proteins that may mediate their interactions with the androgen receptor (AR). Ebp1, a protein cloned via its association with the ErbB3 receptor, binds the AR and inhibits androgen-regulated transactivation of wild-type AR in COS cells. As the complement of coregulators in different cells are important for AR activity, we determined the effect of Ebp1 on AR function in prostate cancer cell lines. In additi… Show more

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Cited by 35 publications
(41 citation statements)
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References 43 publications
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“…Further study is needed of the involvement of non-NRG, non-ERBB regulators of ERBB3, such as CDK5, [122][123][124] BRK, 125 SRC, 126 and MET. 120 The fascinating and widely expressed ERBB3 effector EBP1 has thus far been examined mainly in mammary and prostate cells; [154][155][156][157][158][159][160][161][162][163][164] may it be important also in other cancers where ERBB3 is clearly a player, such as lung and melanoma? It is hoped that full understanding of the regulation and functions of ERBB3 will facilitate its integration into cancer management.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Further study is needed of the involvement of non-NRG, non-ERBB regulators of ERBB3, such as CDK5, [122][123][124] BRK, 125 SRC, 126 and MET. 120 The fascinating and widely expressed ERBB3 effector EBP1 has thus far been examined mainly in mammary and prostate cells; [154][155][156][157][158][159][160][161][162][163][164] may it be important also in other cancers where ERBB3 is clearly a player, such as lung and melanoma? It is hoped that full understanding of the regulation and functions of ERBB3 will facilitate its integration into cancer management.…”
Section: Discussionmentioning
confidence: 99%
“…157,[159][160][161][162] EBP1 contains an LXXLL motif mediating interactions with nuclear hormone receptors and binds androgen receptor, resulting in inhibition of activation of androgen-responsive gene promoters. 157,163,164 Transcriptional effects of EBP1 are dependent on phosphorylation at serine 363. 165 Thus, in both breast and prostate cancer cells, EBP1 is potentially a critical effector for ERBB3 signaling.…”
Section: Newly-identified Proteins Binding Erbb3 Phosphotyrosines-thementioning
confidence: 99%
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“…Our laboratory has demonstrated that Ebp1, a member of the PA2G4 family of proliferation-regulated proteins (12,13) that interacts with the ErbB3 receptor (14), is also an AR corepressor (15). Activity of both exogenous and endogenous AR-regulated promoters was inhibited by ectopic expression of ebp1 independent of prostate cell type (16). Ebp1 interacted with histone deacetylase (HDAC) 2 and also inhibited transcription of cell cycle regulators such as E2F1, cyclin D, and c-myc (17).…”
Section: Down-regulation Of the Androgen Receptor (Ar) Is Being Evalumentioning
confidence: 99%
“…The regulated nuclear accumulation of Ebp1 suggested that Ebp1 might act as a transcription factor or transcriptional coregulator. Indeed, Ebp1 represses transcription of both E2F1 (Xia et al, 2001) and androgen receptor-regulated genes (Zhang et al, 2005a;Zhang and Hamburger, 2005). Ebp1 binds to the E2F-1 promoter in a complex with the E2F-1 transcription factor and retinoblastoma (Rb) (Zhang et al, 2002).…”
Section: Introductionmentioning
confidence: 99%