Specification of Optic Nerve Oligodendrocyte Precursors by Retinal Ganglion Cell Axons

Gao, Limin; Miller, Robert H.

doi:10.1523/jneurosci.0855-06.2006

Cited by 51 publications

(49 citation statements)

References 83 publications

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“…Dixit et al [20]), or diffusivity due to diffusion in the off-track state as investigated by this paper and previous experiments (e.g. Galbraith et al [21], Gao and Miller [22]), among other hypotheses.…”

Section: Introductionsupporting

confidence: 54%

Investigation of the role of diffusivity on spreading, rate, and merging of the bell-shaped waves in slow axonal transport

Кузнецов

Авраменко

Blinov

2010

Int. J. Numer. Meth. Biomed. Engng.

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SUMMARYThis paper investigates the role of diffusivity on spreading, rate, and merging of two waves transporting the same type of cytoskeletal elements (CEs) in slow axonal transport. The two waves (each wave physically represents the total probability density function for the CEs) can be generated by simultaneous microinjections of radiolabeled CEs in two different locations. Alternatively, two waves, one behind another, can be produced by injecting CEs at the same location twice, with a time interval between the injections. Since the waves become wider as they propagate downstream, the two waves eventually merge; this results in the formation of a single wave that moves down the axon. The amplitudes of the waves (before as well as after they merge) decrease as the waves propagate downstream; in addition, the waves spread out during their propagation. The waves spread out faster when diffusivity of free CEs is increased; this agrees with experimental data for the transport of neurofilaments, which are characterized by smaller diffusivity, versus transport of tubulin oligomers, which are characterized by larger diffusivity. The average velocity of CE transport first increases (which is explained by the effect of the initial condition; this effect is somewhat artificial) and then attains an asymptotic value. The case of merging of three waves is also briefly investigated.

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Section: Introductionsupporting

confidence: 54%

Investigation of the role of diffusivity on spreading, rate, and merging of the bell-shaped waves in slow axonal transport

Кузнецов

Авраменко

Blinov

2010

Int. J. Numer. Meth. Biomed. Engng.

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“…Retinal glia have been shown to arise from progenitor cells originating within the floor of the third ventricle (Kim et al, 2006). The glial progenitor cells are induced to produce astrocytes and oligodendrocytes by sonic hedgehog from retinal ganglion cell axons (Gao and Miller, 2006). These glial progenitor cells infiltrate the optic chiasm and migrate down the optic nerve before migrating out of the optic nerve head and onto the inner surface of the retina (Watanabe and Raff, 1988;Fu and Qui, 2001).…”

Section: Resultsmentioning

confidence: 99%

A Common Progenitor for Retinal Astrocytes and Oligodendrocytes

Rompani¹,

Cepko²

2010

J. Neurosci.

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Developing neural tissue undergoes a period of neurogenesis followed by a period of gliogenesis. The lineage relationships among glial cell types have not been defined for most areas of the nervous system. Here we use retroviruses to label clones of glial cells in the chick retina. We found that almost every clone had both astrocytes and oligodendrocytes. In addition, we discovered a novel glial cell type, with features intermediate between those of astrocytes and oligodendrocytes, which we have named the diacyte. Diacytes also share a progenitor cell with both astrocytes and oligodendrocytes.

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“…Hh signaling is known to have many important pleiotropic actions during early eye and retinal development (Dakubo et al, 2003;Levine et al, 1997;Perron et al, 2003;Wang et al, 2002;Zhang and Yang, 2001b). In developing retina, Sonic Hedgehog (Shh) is expressed by the ganglion cells, is exported from the eye via ganglion cell axons, and stimulates the formation of glia in the optic nerve and chiasm (Gao and Miller, 2006;Wallace and Raff, 1999). In the rodent retina, patched (Ptch1; integral membrane receptor for Hh and antagonist of Smo) and smoothened (Smo; co-receptor and activator of intracellular signaling) are expressed by mature Müller glia (Moshiri and Reh, 2004;Nelson et al, 2011;Roesch et al, 2008Roesch et al, , 2012.…”

Section: Introductionmentioning

confidence: 99%

Hedgehog-signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the retina

Todd

Fischer

2015

Development

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Müller glia can be stimulated to de-differentiate and become proliferating progenitor cells that regenerate neurons in the retina. The signaling pathways that regulate the formation of proliferating Müller glia-derived progenitor cells (MGPCs) are beginning to be revealed. The purpose of this study was to investigate whether Hedgehog (Hh) signaling influences the formation of MGPCs in the chick retina. We find that Hh signaling is increased in damaged retinas where MGPCs are known to form. Sonic Hedgehog (Shh) is normally present in the axons of ganglion cells, but becomes associated with Müller glia and MGPCs following retinal damage. Activation of Hh signaling with recombinant human SHH (rhShh) or smoothened agonist (SAG) increased levels of Ptch1, Gli1, Gli2, Gli3, Hes1 and Hes5, and stimulated the formation of proliferating MGPCs in damaged retinas. In undamaged retinas, SAG or rhShh had no apparent effect upon the Müller glia. However, SAG combined with FGF2 potentiated the formation of MGPCs, whereas SAG combined with IGF1 stimulated the nuclear migration of Müller glia, but not the formation of MGPCs. Conversely, inhibition of Hh signaling with KAAD-cyclopamine, Gli antagonists or antibody to Shh reduced numbers of proliferating MGPCs in damaged and FGF2-treated retinas. Hh signaling potentiates Pax6, Klf4 and cFos expression in Müller glia during the formation of MGPCs. We find that FGF2/MAPK signaling recruits Hh signaling into the signaling network that drives the formation of proliferating MGPCs. Our findings implicate Hh signaling as a key component of the network of signaling pathways that promote the de-differentiation of Müller glia and proliferation of MGPCs.

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Specification of Optic Nerve Oligodendrocyte Precursors by Retinal Ganglion Cell Axons

Cited by 51 publications

References 83 publications

Investigation of the role of diffusivity on spreading, rate, and merging of the bell-shaped waves in slow axonal transport

Investigation of the role of diffusivity on spreading, rate, and merging of the bell-shaped waves in slow axonal transport

A Common Progenitor for Retinal Astrocytes and Oligodendrocytes

Hedgehog-signaling stimulates the formation of proliferating Müller glia-derived progenitor cells in the retina

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