Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor β1 Activity in Triggering Lung Fibrosis

Wang, Zhenzhen; Wang, Chunming; Liu, Shang; He, Wei; Wang, Lintao; Gan, Jingjing; Huang, Zhen; Wang, Zhenheng; Wei, Hai-Zhen; Zhang, Junfeng; Dong, Lei

doi:10.1021/acsnano.6b07461

Cited by 79 publications

(65 citation statements)

References 80 publications

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“…GO adsorbs a large amount of serum proteins and induces C3 activation involving the local inflammatory response . Interestingly, specifically formed coronas on silica NPs could specifically recruit transforming growth factor β1 (TGF‐β1) into the corona, which subsequently induces the development of lung fibrosis . The biological relevance of the interactions between nanoparticle–corona complexes and the immune cascade are still unrevealed.…”

Section: Effect Of the Protein Corona On The Biosafety Of Nanoparticlesmentioning

confidence: 99%

The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

2018

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Engineering nanomaterials are increasingly considered promising and powerful biomedical tools or devices for imaging, drug delivery, and cancer therapies, but few nanomaterials have been tested in clinical trials. This wide gap between bench discoveries and clinical application is mainly due to the limited understanding of the biological identity of nanomaterials. When they are exposed to the human body, nanoparticles inevitably interact with bodily fluids and thereby adsorb hundreds of biomolecules. A “biomolecular corona” forms on the surface of nanomaterials and confers a new biological identity for NPs, which determines the following biological events: cellular uptake, immune response, biodistribution, clearance, and toxicity. A deep and thorough understanding of the biological effects triggered by the protein corona in vivo will speed up their translation to the clinic. To date, nearly all studies have attempted to characterize the components of protein coronas depending on different physiochemical properties of NPs. Herein, recent advances are reviewed in order to better understand the impact of the biological effects of the nanoparticle–corona on nanomedicine applications. The recent development of the impact of protein corona formation on the pharmacokinetics of nanomedicines is also highlighted. Finally, the challenges and opportunities of nanomedicine toward future clinical applications are discussed.

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Section: Effect Of the Protein Corona On The Biosafety Of Nanoparticlesmentioning

confidence: 99%

The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

2018

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“…The majority of toxicity studies also usually ignore how the protein corona influences NP-cell interactions despite strong evidence suggesting that it can (Corbo et al 2016). For example, an interesting study by Wang et al (2017) demonstrated how 100 nm silica NPs, when exposed to lung tissue, specifically bind transforming growth factor β1 (TGF-β1) in their protein corona and ultimately induces the development of lung fibrosis in murine models. The high concentration of TGF-β1 in the silica NP corona prolonged activation of the TGF-β/Smad2 pathway, which promotes tissues fibrosis.…”

Section: Toxicitymentioning

confidence: 99%

Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications

et al. 2020

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Background: Fluorescent silica nanoparticles have been extensively utilised in a broad range of biological applications and are facilitated by their predictable, wellunderstood, flexible chemistry and apparent biocompatibility. The ability to couple various siloxane precursors with fluorescent dyes and to be subsequently incorporated into silica nanoparticles has made it possible to engineer these fluorophores-doped nanomaterials to specific optical requirements in biological experimentation. Consequently, this class of nanomaterial has been used in applications across immunodiagnostics, drug delivery and human-trial bioimaging in cancer research. Main body: This review summarises the state-of-the-art of the use of dye-doped silica nanoparticles in bioapplications and firstly accounts for the common nanoparticle synthesis methods, surface modification approaches and different bioconjugation strategies employed to generate biomolecule-coated nanoparticles. The use of dye-doped silica nanoparticles in immunoassays/biosensing, bioimaging and drug delivery is then provided and possible future directions in the field are highlighted. Other non-cancerrelated applications involving silica nanoparticles are also briefly discussed. Importantly, the impact of how the protein corona has changed our understanding of NP interactions with biological systems is described, as well as demonstrations of its capacity to be favourably manipulated. Conclusions: Dye-doped silica nanoparticles have found success in the immunodiagnostics domain and have also shown promise as bioimaging agents in human clinical trials. Their use in cancer delivery has been restricted to murine models, as has been the case for the vast majority of nanomaterials intended for cancer therapy. This is hampered by the need for more human-like disease models and the lack of standardisation towards assessing nanoparticle toxicity. However, developments in the manipulation of the protein corona have improved the understanding of fundamental bio-nano interactions, and will undoubtedly assist in the translation of silica nanoparticles for disease treatment to the clinic.

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“…The surface charge of silica NPs (100 nm) affected the recruitment of transforming growth factor (TGF)-β1 to the NP surface. Positively charged aminated-and polyetherimide (PEI)-silica NPs completely failed to adsorb TGF-β1 in a mouse lung tissue homogenate supernatant, while negatively charged hydrogenated, dextransilica, and gelatin-silica NPs largely adsorbed TGF-β1 (Wang et al, 2017). The surface charge of nanodiamonds (5 nm) could regulate protein binding speed.…”

Section: Surface Chargementioning

confidence: 99%

Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry

Sun

Jiang

Li-jun

et al. 2019

Front. Bioeng. Biotechnol.

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Nanoparticles (NPs) are widely used in a variety of fields, including those related to consumer products, architecture, energy, and biomedicine. Once they enter the human body, NPs contact proteins in the blood and interact with cells in organs, which may induce cytotoxicity. Among the various factors of NP surface chemistry, surface charges, hydrophobicity levels and combinatorial decorations are found to play key roles inregulating typical cytotoxicity-related bioeffects, including protein binding, cellular uptake, oxidative stress, autophagy, inflammation, and apoptosis. In this review, we summarize the recent progress made in directing the levels and molecular pathways of these cytotoxicity-related effects by the purposeful design of NP surface charge, hydrophobicity, and combinatorial decorations.

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Specifically Formed Corona on Silica Nanoparticles Enhances Transforming Growth Factor β1 Activity in Triggering Lung Fibrosis

Cited by 79 publications

References 80 publications

The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine

Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications

Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry

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