Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging

Liu, Dongbo; Chen, Chunli; Hu, Guangyuan; Mei, Qi; Qian, Hong; Long, Guoxian; Hu, Guoqing

doi:10.1093/abbs/gmr010

Cited by 16 publications

(11 citation statements)

References 29 publications

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“…A number of nanoparticle systems have been investigated in conjunction with EGFR targeting toward a variety of cancers, including nanoparticles composed of gold [13], iron oxide [14,15], dendrimers [16], high-density lipoprotein [17], L-protein [18], poly(ε-caprolactone) [19], lactic acid–lysine copolymers [20], gelatin [21], human serum albumin [22], heparin [23] and liposomes [24]. …”

mentioning

confidence: 99%

Polydopamine-Enabled Surface Functionalization of Gold Nanorods for Cancer Cell-Targeted Imaging and Photothermal Therapy

et al. 2012

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Aim A novel biomimetic strategy was employed for presenting antibodies on gold nanorods (NRs) to target growth factor receptors on cancer cells for use in photothermal therapy. Materials & methods Polydopamine (PD) was polymerized onto gold NRs, and EGF receptor antibodies (anti-EGFR) were immobilized onto the layer. Cell-binding affinity and light-activated cell death of cancer cells incubated with anti-EGFR-PD-NRs were quantified by optical imaging. Results PD was deposited onto gold NRs, and antibodies were bound to PD-coated NRs. Anti-EGFR-PD-NRs were stable in media, and were specifically bound to EGFR-overexpressing cells. Illumination of cells targeted with anti-EGFR-PD-NRs enhanced cell death compared with nonirradiated controls and cells treated with antibody-free NRs. Conclusion PD facilitates the surface functionalization of gold NRs with biomolecules, allowing cell targeting and photothermal killing of cancer cells. PD can potentially coat a large variety of nanoparticles with targeting ligands as a strategy for biofunctionalization of diagnostic and therapeutic nanoparticles.

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confidence: 99%

Polydopamine-Enabled Surface Functionalization of Gold Nanorods for Cancer Cell-Targeted Imaging and Photothermal Therapy

et al. 2012

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“…Effective targeting of superparamagnetic iron oxide nanoparticles, excellent MRI contrast agents, to cells over-expressing EGFR has been demonstrated (Liu et al 2011; Bouras et al 2012). Liu et al (2011) proposed MRI imaging of cetuximab-conjugated iron oxide nanoparticles for early detection of nasopharyngeal carcinoma as well as for defining the clinical target volume for the application of radiotherapy.…”

Section: Resultsmentioning

confidence: 99%

“…Liu et al (2011) proposed MRI imaging of cetuximab-conjugated iron oxide nanoparticles for early detection of nasopharyngeal carcinoma as well as for defining the clinical target volume for the application of radiotherapy. Similarly, Bouras et al (2012) have shown that cetuximab-conjugated iron oxide nanoparticles can provide MRI contrast enhancement as well as confer radiosensitivity to glioblastoma cell lines in vitro and in vivo tumors.…”

Section: Resultsmentioning

confidence: 99%

Cancer active targeting by nanoparticles: a comprehensive review of literature

Bazak

Houri

Achy

et al. 2014

J Cancer Res Clin Oncol

590

359

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Purpose Cancer is one of the leading causes of death, and thus, the scientific community has but great efforts to improve cancer management. Among the major challenges in cancer management is development of agents that can be used for early diagnosis and effective therapy. Conventional cancer management frequently lacks accurate tools for detection of early tumors and has an associated risk of serious side effects of chemotherapeutics. The need to optimize therapeutic ratio as the difference with which a treatment affects cancer cells versus healthy tissues lead to idea that it is needful to have a treatment that could act a the “magic bullet”—recognize cancer cells only. Nanoparticle platforms offer a variety of potentially efficient solutions for development of targeted agents that can be exploited for cancer diagnosis and treatment. There are two ways by which targeting of nanoparticles can be achieved, namely passive and active targeting. Passive targeting allows for the efficient localization of nanoparticles within the tumor microenvironment. Active targeting facilitates the active uptake of nanoparticles by the tumor cells themselves. Methods Relevant English electronic databases and scientifically published original articles and reviews were systematically searched for the purpose of this review. Results In this report, we present a comprehensive review of literatures focusing on the active targeting of nanoparticles to cancer cells, including antibody and antibody fragment-based targeting, antigen-based targeting, aptamer-based targeting, as well as ligand-based targeting. Conclusion To date, the optimum targeting strategy has not yet been announced, each has its own advantages and disadvantages even though a number of them have found their way for clinical application. Perhaps, a combination of strategies can be employed to improve the precision of drug delivery, paving the way for a more effective personalized therapy.

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“…47 Liu et al also found that C225-USPIO has potential use as an MRI contrast agent to noninvasively detect early-stage nasopharyngeal carcinoma with EGFR overexpression. 48 Furthermore, Shevtsov et al 49 studied SPION conjugated with recombinant human epidermal growth factor (SPION-EGF) as a potential agent for MRI contrast enhancement in malignant brain tumors. They first analyzed the interaction of SPION-EGF conjugates with cells in a C6 glioma cell culture.…”

Section: Using Spion In Cancer Imaging Applicationsmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles for MR imaging of pancreatic cancer: Potential for early diagnosis through targeted strategies

Zhang¹,

Zou²,

Chen³

et al. 2015

Asia-Pac J Clncl Oncology

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Superparamagnetic iron oxide nanoparticles (SPION)-based magnetic resonance imaging is a powerful, noninvasive tool in biomedical imaging. The recent embedding of SPIO in nanoencapsulations that had different controllable surface properties has now made it possible to use SPIO in the imaging of metabolic processes. The two major issues to realize maximized and selective SPIO cancer targeting are the minimization of macrophage uptake and the preferential binding to cancerous cells over healthy neighbor cells. The utility of SPIO has been shown in clinical applications using a series of marketed SPION-based contrast agents. Applications have ranged from detecting inflammatory diseases to the specific identification of cell surface markers expressed on tumors. This review focuses on iron-oxide-based nanoparticles, to include the physiochemical properties of SPION surface engineering and its synthetic methods as well as SPIO imaging applications and specifically targeted SPIO conjugates (e.g. targeted probes) for labeling cancerous, cell-surface molecules. As a specific application of this technology, we discuss its use in the imaging of pancreatic duct adenocarcinoma in addition to its potential for use in early diagnosis through targeted strategies.

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Specific targeting of nasopharyngeal carcinoma cell line CNE1 by C225-conjugated ultrasmall superparamagnetic iron oxide particles with magnetic resonance imaging

Cited by 16 publications

References 29 publications

Polydopamine-Enabled Surface Functionalization of Gold Nanorods for Cancer Cell-Targeted Imaging and Photothermal Therapy

Polydopamine-Enabled Surface Functionalization of Gold Nanorods for Cancer Cell-Targeted Imaging and Photothermal Therapy

Cancer active targeting by nanoparticles: a comprehensive review of literature

Superparamagnetic iron oxide nanoparticles for MR imaging of pancreatic cancer: Potential for early diagnosis through targeted strategies

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