Specific species of intestinal bacteria influence the induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats

Onoue, Masaharu; Kado, Shouichi; Sakaitani, Yukiko; Uchida, Kazumi; Morotomi, Masami

doi:10.1016/s0304-3835(97)04698-3

Cited by 80 publications

(41 citation statements)

References 15 publications

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“…Effects of dietary compounds on DMH-metabolizing (microbial) enzymes such as b-glucuronidase, b-glucosidase, b-galactosidase and mucinase may influence tumour development (Reddy et al, 1977;Roberton, 1993). A number of studies have shown that gut microbial enzymes play a significant role in the aetiology of colon cancer (Onoue et al, 1997;George et al, 2004). These enzymes are involved in DMH metabolism, causing the release of the reactive metabolite methylazoxymethanol (MAM) from its conjugate in the colon; therefore a decrease in b-glucuronidase and bglucosidase may be protective.…”

Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon

Chang

Shim

Cha

et al. 2012

Journal of Medical Microbiology

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Lactobacillus acidophilus KFRI342, isolated from the Korean traditional food kimchi, was investigated for its suitability as a dietary probiotic. The effects of L. acidophilus KFRI342 on the development of chemically induced (1,2-dimethylhydrazine; DMH) precancerous cytological changes of the colon were investigated in rats. Forty-five male F344 rats were randomly divided into three dietary groups. The control group received a high-fat diet (HF), a second group received a high-fat diet containing the carcinogen (HFC), and a final group received a high-fat diet containing the carcinogen and L. acidophilus KFRI342 (HFCL). L. acidophilus KFRI342 was administered orally three times per week at 2¾10 9 c.f.u. ml -1 . L. acidophilus KFRI342 treatments decreased the number of Escherichia coli in faecal samples, the enzyme activities of b-glucuronidase and b-glucosidase, and plasma triglyceride concentration compared to the HF and HFC treatments (P,0.05). L. acidophilus KFRI342 consumption also decreased the ratio of aberrant crypts to aberrant crypt foci incidence and the number of aberrant crypts in HFCL rats. Therefore, L. acidophilus showed potential probiotic activity as an inhibitor of DMH-induced symptoms in live rats. Our in vivo studies indicate that L. acidophilus from kimchi may be suitable as a probiotic for human use.

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Section: Discussionmentioning

confidence: 99%

Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon

Chang

Shim

Cha

et al. 2012

Journal of Medical Microbiology

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“…We maintained mice in a clean environment as SPF mice, which in part may be responsible for reducing colon carcinogenesis in the present experiment. Some epidemiological studies suggest that the intestinal flora can increase the risk of colon cancer 30,31 . Using conventional animals, the presence of the intestinal flora was associated with increasing formation of colon tumors 32 in contrast to germ-free animals.…”

Section: Discussionmentioning

confidence: 99%

Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice

et al. 2004

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Abstract:The carcinogenic potential of long term exposure to 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) was investigated in severe combined immunodeficiency (SCID) mice. A total of 130 female SCID mice, 7 weeks old, were administered 0 (45 mice) or 300 ppm IQ (85 mice) in the diet for 78 weeks. IQ-treatment and control groups were sacrificed at weeks 32, 52, and 78, and examined for tumorigenicity in the colon and other organs. The survival rate was 46% (control group) and 50% (IQ-treatment group) at the termination of the experiment 78 weeks. Tumors in the liver were significantly increased in the 300 ppm-IQ treated mice. Concerning colon cancer development, aberrant crypt foci (ACF), putative pre-cancerous lesions of the colon, were found in all IQ-treated mice at 32, 52, and 78 weeks. The number of ACF was increased in relation to the duration of exposure. The major induction site of ACF was the proximal colon, however, no colon tumors were observed except for an inflammatory polyp. One of the intestinal microflora, Lactobacillus, which was reported to detoxify IQ, was detected in IQ-treated and non-treated mice. Thus IQ showed hepatocarcinogenicity in SCID mice of the present study, but not colon carcinogenicity. (J Toxicol Pathol 2004; 17: 17-23)

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“…Studies in rats, utilizing chemical carcinogens [1,2-dimethyl-hydrazine] to induce early cellular neoplastic changes with aberrant crypt foci, could be infl uenced by specifi c species of intestinal fl ora, and some bacteria might behave as promoters and others as antipromoters in carcinogenesis [ 19 ]. For instance, Bifi dobacterium breve inoculated orally to gnotobiotic rats had lower rates of aberrant crypt foci than with other bacteria after treatment with a carcinogen.…”

Section: Animal Models Of Colorectal Cancermentioning

confidence: 99%

Microbes in Colon Cancer and Inflammatory Bowel Disease

Fong

2014

The Role of Microbes in Common Non-Infectious Diseases

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Colorectal cancer [CRC] is the third most common tumor and fourth most common cause of cancer death in the world [ 1 ]. It is prevalent in many countries but more common in developed nations. In the United States [US] CRC estimated new cases in 2008 were 77,250 in men and 71,560 in women [ 1 ]. The higher incidence of CRC in developed countries has been attributed to dietary and lifestyle habits, and the infl uence of genetic predisposition.

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Specific species of intestinal bacteria influence the induction of aberrant crypt foci by 1,2-dimethylhydrazine in rats

Cited by 80 publications

References 15 publications

Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon

Effect of Lactobacillus acidophilus KFRI342 on the development of chemically induced precancerous growths in the rat colon

Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-<i>f</i>]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice

Microbes in Colon Cancer and Inflammatory Bowel Disease

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