SPECIFIC ROLE OF RXRα IN MEDIATING THE <i>ALL‐TRANS</i> RETINOIC ACID‐INDUCED GROWTH ARREST OF C2 MYOGENIC CELLS

Froeschle, Anne; Carnac, Gilles; Alric, Séverine; Montarras, Didier; Pinset, Christian; Rochette‐Egly, Cécile; Bonnieu, Anne

doi:10.1016/s0248-4900(97)86865-7

Cited by 4 publications

(4 citation statements)

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“…FGF signaling can also promote myogenesis in amniotes and may play a role in mediating the myogenic “community effect” (Marics et al, 2002; Buckingham, 2003). RA also promotes myogenesis in amniotes (Froeschle et al, 1996; Alric et al, 1998). Whether other signals that regulate myogenic differentiation from the amniote dermomyotome, such as Wnt, BMP4/7, and Notch signaling also regulate the fates of the teleost dermomyotome remains to be determined.…”

Section: Signaling Molecules and The Dermomyotomementioning

confidence: 99%

The teleost dermomyotome

Stellabotte

Devoto

2007

Developmental Dynamics

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Recent work in teleosts has renewed interest in the dermomyotome, which was initially characterized in the late 19th century. We review the evidence for the teleost dermomyotome, comparing it to the more well-characterized amniote dermomyotome. We discuss primary myotome morphogenesis, the relationship between the primary myotome and the dermomyotome, the differentiation of axial muscle, appendicular muscle, and dermis from the dermomyotome, and the signaling molecules that regulate myotome growth from myogenic precursors within the dermomyotome. The recognition of a dermomyotome in teleosts provides a new perspective on teleost muscle growth, as well as a fruitful approach to understanding the vertebrate dermomyotome. Developmental Dynamics 236:2432-2443, 2007.

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Section: Signaling Molecules and The Dermomyotomementioning

confidence: 99%

The teleost dermomyotome

Stellabotte

Devoto

2007

Developmental Dynamics

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“…RXRα has unique characteristics that distinguish it from the other RAR and RXR subtypes 15, 24, 25. It is the most abundant of the RXR subtypes, it mediates the heterodimerization of RARs with other members in the thyroid hormone nuclear transcription receptor family, it is essential for the functional activation of RARs by their ligands, and it has the ability to form homodimers with itself or heterodimers with other nucleic receptors such as PPARγ and VitD.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐Apc^Min/+ mouse model of intestinal cancer

Volate

Muga

Issa

et al. 2009

Molecular Carcinogenesis

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We investigated the possible mechanisms of inhibition of colorectal carcinogenesis by green tea (GT) in azoxymethane-treated (AOM) ApcMin/+ mice. Mice received water or a 0.6% (w/v) solution of GT as the only source of beverage. GT treatment commenced at the 8th week of age and lasted for 8 wk. The treatment caused a statistically significant reduction in the number of newly formed tumors (28%, P <0.05). Immunohistochemical analysis showed that GT decreased the levels of β-catenin and its downstream target cyclin D1. To probe a mechanism, we further investigated the expression of retinoic X receptor alpha (RXRα) in AOM/ApcMin/+ tumors. Our results show that RXRα is selectively downregulated in AOM/ApcMin/+ mouse intestinal tumors. In contrast, other retinoic receptors including retinoic acid receptor alpha (RARα), RARβ, RXRβ, and RXRγ were all expressed in ApcMin/+ adenomas. Furthermore, our results show that RXRα downregulation is an early event in colorectal carcinogenesis and is independent of β-catenin expression. GT significantly increased the protein levels of RXRα. In addition, RT-PCR analysis showed that GT induced a similar increase in the levels of RXRα mRNA. Genomic bisulfite treatment of colonic DNA followed by pyrosequencing of 24 CpG sites in the promoter region of RXRα gene showed a significant decrease in CpG methylation with GT treatment. The results suggest that a low concentration of GT is sufficient to desilence RXRα and inhibit intestinal tumorigenesis in the ApcMin/+ mouse.

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“…(cellular retinoic acid-binding protein 2). Retinoic acid has previously been shown to induce growth arrest of myogenic cells (Froeschlé et al, 1996) and promote muscle cell differentiation (Halevy and Lerman, 1993).…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic changes in bovine skeletal muscle cells after resveratrol treatment

Hao

Wang

et al. 2020

Gene

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SPECIFIC ROLE OF RXRα IN MEDIATING THE ALL‐TRANS RETINOIC ACID‐INDUCED GROWTH ARREST OF C2 MYOGENIC CELLS

Cited by 4 publications

References 0 publications

The teleost dermomyotome

The teleost dermomyotome

Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐Apc^Min/+ mouse model of intestinal cancer

Transcriptomic changes in bovine skeletal muscle cells after resveratrol treatment

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SPECIFIC ROLE OF RXRα IN MEDIATING THE ALL‐TRANS RETINOIC ACID‐INDUCED GROWTH ARREST OF C2 MYOGENIC CELLS

Cited by 4 publications

References 0 publications

The teleost dermomyotome

The teleost dermomyotome

Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐ApcMin/+ mouse model of intestinal cancer

Transcriptomic changes in bovine skeletal muscle cells after resveratrol treatment

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Product

Resources

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Epigenetic modulation of the retinoid X receptor α by green tea in the azoxymethane‐Apc^Min/+ mouse model of intestinal cancer