Specific role of polysorbate 80 coating on the targeting of nanoparticles to the brain

Sun, WaiChing; Xie, Changsheng; Wang, Huafang; Hu, Yu Lin

doi:10.1016/j.biomaterials.2003.09.087

Cited by 188 publications

(113 citation statements)

References 23 publications

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“…Polymeric Nanoparticles are nanosized carriers (1 -1000 nm), made of natural or synthetic polymers, in which the drug can be loaded in the solid state or in solution, or adsorbed or chemically linked to the surface. Nowadays, the use of polymeric Nanoparticle is one of the most promising approaches for CNS drug delivery [35] . As name only suggest polymeric nanoparticles are nanoparticles which are prepared from polymers.…”

Section: Polymeric Nanoparticle As a Drug Delivery Tool For Brain Tarmentioning

confidence: 99%

Drug Delivery to The Brain Using Polymeric Nanoparticles: A Review

Bhatt¹,

Ganesh²,

Kothiyal³

2013

Int. J. Pharma Life Sci.

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Nanoparticle drug carriers consist of solid biodegradable particles in size ranging from 10 to 1000 nm (50-300 nm generally). The use of minute particles as drug carriers for targeted treatment has been studied over a long period of time. A selective accumulation of active substances in target tissues has been demonstrated for certain so-called nanocarrier systems that are administered bound to pharmaceutical drugs. Great expectations are placed on nanocarrier systems that can overcome natural barriers such as the blood-brain barrier (BBB) and transport the medication directly to the desired tissue and thus heal neurological diseases that were formerly incurable. Polymeric Nanoparticle have been shown to be promising carriers for CNS drug delivery due to their potential both in encapsulating drugs, hence protecting them from excretion and metabolism, and in delivering active agents across the blood -brain barrier without inflicting any damage to the barrier. Different polymers have been used and different strategies like surface modification have been done to increase the retention time of nanoparticles.

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Section: Polymeric Nanoparticle As a Drug Delivery Tool For Brain Tarmentioning

confidence: 99%

Drug Delivery to The Brain Using Polymeric Nanoparticles: A Review

Bhatt¹,

Ganesh²,

Kothiyal³

2013

Int. J. Pharma Life Sci.

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“…Three papers claimed there was no evidence showing that unmodified NPs crossed the BBB by detecting fluorescence in the brain [16,22,27] . Two studies reported low intensity of a fluorescent probe loaded in unmodified NPs after administration in the brain [25,32] .…”

Section: Unmodified Plga/pla Npsmentioning

confidence: 99%

“…Among 29 papers cited in this review, 9 papers performed in vitro studies [20,23,24,31,33,37,38,40] , 8 papers focused on in vivo studies [13,15,16,18,21,25,27,30] , and 12 papers did both in vitro and in vivo studies [14,17,19,22,26,28,29,32,34,35,39,41] .…”

Section: Introductionmentioning

confidence: 99%

PLA/PLGA nanoparticles for delivery of drugs across the blood-brain barrier

Sabliov

2013

Nanotechnology Reviews

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Abstract:The blood-brain barrier (BBB), which protects the central nervous system (CNS) from unnecessary substances, is a challenging obstacle in the treatment of CNS disease. Many therapeutic agents such as hydrophilic and macromolecular drugs cannot overcome the BBB. One promising solution is the employment of polymeric nanoparticles (NPs) such as poly (lactic-co-glycolic acid) (PLGA) NPs as drug carrier. Over the past few years, significant breakthroughs have been made in developing suitable PLGA and poly (lactic acid) (PLA) NPs for drug delivery across the BBB. Recent advances on PLGA/PLA NPs enhanced neural delivery of drugs are reviewed in this paper. Both in vitro and in vivo studies are included. In these papers, enhanced cellular uptake and therapeutic efficacy of drugs delivered with modified PLGA/PLA NPs compared with free drugs or drugs delivered by unmodified PLGA/ PLA NPs were shown; no significant in vitro cytotoxicity was observed for PLGA/PLA NPs. Surface modification of PLGA/PLA NPs by coating with surfactants/polymers or covalently conjugating the NPs with targeting ligands has been confirmed to enhance drug delivery across the BBB. Most unmodified PLGA NPs showed low brain uptake ( < 1 % ), which indirectly confirms the safety of PLGA/PLA NPs used for other purposes than treating CNS diseases.

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“…Tween 80 coated nanoparticles have been proposed to offer benefits in terms of their targeting efficacy towards brain (Kreuter, 2001). The proposed mechanism of brain specificity is their preferential binding with Apo-E (present in the plasma) which would mimic low density lipoproteins (LDL), and thus bind the LDL receptors present on brain micro vascular endothelial cells (BMEC) (Misra et al, 2003;Sun et al, 2004;Tamai & Tsuji, 1996). The cryoprotectant is added owing to its protective effect and thus preventing particle aggregation during lyophillization process for separation of nanoparticles, which upon reconstitution offers improved re-dispersibility, injectability and syringeability.…”

Section: Discussionmentioning

confidence: 99%