Specific recognition and photothermal release of circulating tumor cells using near-infrared light-responsive 2D MXene nanosheets@hydrogel membranes

Recent progress of nanostructure-based enrichment of circulating tumor cells and downstream analysis

“…You et al designed and prepared a Ti 3 C 2 T x -MXene nanosheets-near-infrared responsive gelatin hydrogel membrane for the specific capture and release of CTCs. 117 The surface of anti-EpCAM modified Ti 3 C 2 T x @gelatin film can recognize highly specific EpCAM positive cells, and it has two release modes: temperature response release and near infrared response fixed-point release. The average effective release rate is 89%, and the cell vitality is 87%.…”

MXenes in photomedicine: advances and prospects

“…MXene (Ti 3 C 2 T x ) nanosheet-entrenched thermoresponsive gelatin hydrogel membranes with NIR light responsiveness exhibited unique potentials for sensitive and selective seizure and discharge of circulating tumor cells. 93 This membrane was designed by moulding Ti 3 C 2 T x -entrenched gelatin onto a substrate, followed by amendment with epithelial-cell adhesion-molecule antibody for the precise detection and isolation of circulating tumor cells from whole blood. Consequently, the incarcerated cells could be discharged without damage with dual-mode covering temperature-receptive discharge and photothermal site delivery; the common proficient discharge rate was ∼89% of seized cells with a steady cell viability of 87% through the irradiation of NIR light.…”

“…Consequently, the incarcerated cells could be discharged without damage with dual-mode covering temperature-receptive discharge and photothermal site delivery; the common proficient discharge rate was ∼89% of seized cells with a steady cell viability of 87% through the irradiation of NIR light. 93 Besides, MXene (V 2 C) QDs with efficient photothermal effects in the near infrared-II area were utilized for constructing an innovative nanosystem containing an engineered exosome vector for photothermal cancer nanotherapy under low-temperature conditions (Fig. 7).…”

Thermal Properties of MXenes and Relevant Applications

“…It has been shown that the response signal in detecting biological species by electrochemical methods can be enhanced by an increase in the operating temperature, [166] indicating the [155] Reproduced with permission from ref. [155] Copyright 2020 Elsevier.…”

“…It has been shown that the response signal in detecting biological species by electrochemical methods can be enhanced by an increase in the operating temperature, [166] indicating the potential of MXenes to be used as signal amplifiers due to their efficient photothermal conversion capability under illumination [139,167] . For instance, Ti 3 C 2 T x @thionine hybrids were incorporated into an electrochemical sensing system for human epididymis protein 4 (HE4), in which the output current intensity of the protein sensor under solar irradiation was higher than that of the counterpart in dark at the same concentration levels (from 10 −5 –1 ng ml −1 ), as shown in Figure 13(b) [168] .…”