Specific properties of the extracellular chondroitin sulphate proteoglycans in the mandibular condylar growth centre in pigs

Roth, Sylke; Müller, Karin; Fischer, Dagmar‐Christiane; Dannhauer, Karl-Heinz

doi:10.1016/s0003-9969(97)83718-1

Cited by 41 publications

(31 citation statements)

References 51 publications

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“…The cartilage layer is not continuous on the eminence, and even where present the cartilage is much thinner than on the condyle. Specifically, the eminence lacks the hypertrophic, mineralizing, and erosive zones that characterize growth cartilages, including the pig condyle (Roth et al, 1997). The surface coverings of the articular eminence show no obvious regional variation, but those of the condyle show striking changes from anterior to posterior.…”

Section: Bony Elements and Articular Surfacesmentioning

confidence: 99%

“…The pig TMJ has already been used to study discal mechanical properties (Nickel and McLachlan, 1994;Kuboki et al, 1997;Nickel et al, 2000), synovial fluid pressure (Roth et al, 1984), reactions to occlusal disturbances (Ulrici et al, 1988;Dannhauer, 1992;Sindelar et al, 2000), and as a mechanical (Liu and Herring, 2000b) or surgical (Timmel and Grundschober, 1982) model. Proteoglycan content has been examined in the disc (Sindelar et al, 2000) and the condylar soft tissues (Mü ller et al, 1996;Roth et al, 1997), and Moroco et al (1997) have looked at age changes of collagen II and TGF-␤ in the condylar cartilage.…”

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confidence: 99%

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Temporomandibular joint in miniature pigs: Anatomy, cell replication, and relation to loading

et al. 2002

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The mechanical environment is a regulator of growth and adaptation of the musculoskeletal system, including joints. Although pigs (Sus scrofa) are used frequently as models for temporomandibular joint (TMJ) dysfunction, no systematic description of microanatomy exists for this species. We injected the thymidine analog 5-bromo-2Ј-deoxyuridine (BrdU) into 10-to 11-month-old miniature pigs that were undergoing measurements of TMJ bone strain. Ten hr later, the animals were sacrificed and their heads were perfused. Histological sections were used to map the distribution of replicating cells. Additional observations were made on gross dissections of jaw joints obtained from an abattoir. The pig TMJ is better supported than that of humans laterally and medially, but more vulnerable posteriorly. The posterior attachment area of the intra-articular disc is fibro-fatty rather than vascular, as in humans. Cartilage lines the articular eminence as well as the condylar surface. At the posterosuperior region of the condyle, the cartilage ends abruptly and is replaced by an invaginating, actively replicating periosteum. Almost all of the BrdU-labeled cells resided in the prechondroblastic zones. The condyle had more replicating cells than did the eminence (P Ͻ 0.02), but lateral and medial locations did not differ in either element. In sagittal sections, the condyle had more replicating cells posteriorly (P Ͻ 0.001), but no A-P differences were seen in the eminence. Comparisons of these data with data on bone strain indicate that increased loading is negatively associated with cell replication. Anat Rec 266: 152-166, 2002.

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Section: Bony Elements and Articular Surfacesmentioning

confidence: 99%

mentioning

confidence: 99%

Temporomandibular joint in miniature pigs: Anatomy, cell replication, and relation to loading

et al. 2002

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“…Beneath the surface layer there are differentiative cells and proliferative chondroblasts followed by hypertrophied chondrocytes. All cell layers of the condylar cartilage secrete extracellular matrix, which is well adjusted to the functional adaptive demands of growth and articulation [Öberg, 1964;Copray et al, 1988;Roth et al, 1997;Pietilä et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

Unilateral Masticatory Function Changes the Proteoglycan Content of Mandibular Condylar Cartilage in Rabbit

Poikela

Kantomaa

Pirttiniemi

et al. 2000

Cells Tissues Organs

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Unilateral masticatory function was induced in 10-day-old rabbits by grinding the right side molars out of occlusion under general anesthesia. The grinding procedure was repeated twice a week thereafter. They were killed at the ages of 25 and 35 days. Rabbits of the same age with uninterfered occlusions served as controls. The changes in articular cartilage of the mandibular condyle were studied biochemically and histochemically. There was a significant decrease in the proteoglycan content of the condylar cartilage in both groups of animals subjected to molar grinding compared to the animals with untouched occlusions. Especially the amount of aggregating proteoglycans was reduced. The condylar cartilage matrix synthesis is sensitive to loading produced by masticatory function during growth. The mechanical properties of the articular cartilage after a period of unilateral mastication will be impaired and it is possible that this makes the joint cartilage more susceptible to pathological events.

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“…Other groups describe a diffuse distribution in loose connective tissue, often associated with the elastic fiber network, but also in the nervous system, in the basal layers of the epithelium, on the luminal surface of some excretory cells and in all three wall layers of blood vessels [Bode-Lesniewska et al, 1996]. After intense enzymatic pretreatment versican-positive deposits have been detected in cartilage growth centers of the mandible [Roth et al, 1997]. Most authors define mature hyaline cartilage as negative, whereas in fibrous and elastic 5 Triticum vulgare agglutinin (WGA).…”

Section: Proteoglycans and Chondrogenesismentioning

confidence: 99%

“…cartilage this proteoglycan seems to be present in high concentrations [Bode-Lesniewska et al, 1996;Roth et al, 1997].…”

Section: Proteoglycans and Chondrogenesismentioning

confidence: 99%

Glycoconjugate Expression and Cartilage Development of the Cranial Skeleton

Zschäbitz

1998

Cells Tissues Organs

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Only few detailed investigations have focused on the glycobiology of cranial development. The functional elements in most inductive and morphogenetic processes are not individual cells, but rather collectives of interacting populations and extracellular matrix components that give rise to specific tissues and organs. Experimental evidence strongly suggests that sugar chains not only confer morphological characteristics. Complex carbohydrate molecules and their corresponding receptors are involved in recognition processes decoding biological information during cranial morphogenesis. The distribution patterns of glycoconjugates are highly dynamic and show a clear correlation with characteristic structural modifications. However, due to the intricate interactions in vivo the definitive physiological impact of these observations has to be established in further studies. In this review, the spatial and temporal patterns of lectin-reactive epitopes and selected receptor types are presented and discussed with regard to their potential importance to physiological craniogenesis.

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Specific properties of the extracellular chondroitin sulphate proteoglycans in the mandibular condylar growth centre in pigs

Cited by 41 publications

References 51 publications

Temporomandibular joint in miniature pigs: Anatomy, cell replication, and relation to loading

Temporomandibular joint in miniature pigs: Anatomy, cell replication, and relation to loading

Unilateral Masticatory Function Changes the Proteoglycan Content of Mandibular Condylar Cartilage in Rabbit

Glycoconjugate Expression and Cartilage Development of the Cranial Skeleton

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