2017
DOI: 10.1016/j.freeradbiomed.2016.11.028
|View full text |Cite
|
Sign up to set email alerts
|

Specific point mutations in key redox enzymes are associated with chemoresistance in epithelial ovarian cancer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
63
0
3

Year Published

2018
2018
2022
2022

Publication Types

Select...
4
3

Relationship

1
6

Authors

Journals

citations
Cited by 35 publications
(66 citation statements)
references
References 61 publications
0
63
0
3
Order By: Relevance
“…The correction or deletion of resistance‐related genes is a promising development for tumor therapy. Current studies on drug resistance of tumor cells using CRISPR/Cas9 in lung cancer, breast cancer, melanoma, urogenital tumors, and gastrointestinal tumors about chemotherapy drugs, targeted drugs, and inhibitors were summarized in Table . Besides the above‐mentioned studies, there are other studies on the mechanisms related to drug resistance of other malignant tumors cells by using CRISPR/Cas9.…”
Section: Using Crispr/cas9 In the Study Of Tumor Therapiesmentioning
confidence: 99%
See 1 more Smart Citation
“…The correction or deletion of resistance‐related genes is a promising development for tumor therapy. Current studies on drug resistance of tumor cells using CRISPR/Cas9 in lung cancer, breast cancer, melanoma, urogenital tumors, and gastrointestinal tumors about chemotherapy drugs, targeted drugs, and inhibitors were summarized in Table . Besides the above‐mentioned studies, there are other studies on the mechanisms related to drug resistance of other malignant tumors cells by using CRISPR/Cas9.…”
Section: Using Crispr/cas9 In the Study Of Tumor Therapiesmentioning
confidence: 99%
“…Current studies on drug resistance of tumor cells using CRISPR/Cas9 in lung cancer, breast cancer, melanoma, urogenital tumors, and gastrointestinal tumors about chemotherapy drugs, targeted drugs, and inhibitors were summarized in Table 2. 56,88,94,97,100,113,[141][142][143][144][145][146][147][148][149][150][151][152][153][154][155] Compared with wild-type cells, ATG5 KO cells had stronger migration ability and significantly increased resistance to the Src tyrosine kinase inhibitor PP2. 156 The results showed that autophagy deficiency can induce malignant cell transformation and resistance to PP2.…”
Section: Drug Resistance Study Of Tumorsmentioning
confidence: 99%
“…Pro-oxidant enzymes such as myeloperoxidase (MPO), inducible nitric oxide synthase (iNOS) and NAD(P)H oxidase have been associated with initiation, progression, survival, and increased risk in cancers such as breast, ovarian, lung, prostate, bladder, colorectal and malignant melanoma [21,44]. Moreover, the expression of those key pro-oxidant enzymes was found to change based on the histological type and grade of the tumor [21,45,46]. Likewise, antioxidants have also been associated with initiation, progression, survival, and increased risk in cancers such as lung, head and neck, and prostate cancer [47][48][49][50].…”
Section: Cancer Cells Are Under Intrinsic Oxidative Stressmentioning
confidence: 99%
“…Likewise, antioxidants have also been associated with initiation, progression, survival, and increased risk in cancers such as lung, head and neck, and prostate cancer [47][48][49][50]. The expression of GSR and GPX, key antioxidant enzymes, has also been reported to be altered in various types of cancer [21]. The activity and expression of SOD, a powerful antioxidant enzyme, has been reported to be decreased in colorectal carcinomas, pancreatic, lung, gastric, ovarian, and breast cancers [21,45,46].…”
Section: Cancer Cells Are Under Intrinsic Oxidative Stressmentioning
confidence: 99%
See 1 more Smart Citation