Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome

Fulle, Stefania; Mecocci, Patrizia; Fanò, Giorgio; Vecchiet, I.; Vecchini, Alba; Racciotti, Delia; Cherubini, Antonio; Pizzigallo, Eligio; Vecchiet, L; Senin, Umberto; Beal, M. Flint

doi:10.1016/s0891-5849(00)00419-6

Cited by 144 publications

(103 citation statements)

References 40 publications

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“…This increases inner membrane leakiness and lowers trans-membrane potential of the inner mitochondrial membrane (MIM), thus impairing mitochondrial function and production of ATP, resulting in reduced physical and mental performance with aging and disease [20] [24]- [26]. For example, chronic fatigue syndrome patients present with evidence of oxidative damage to DNA and lipids [26] [27], such as oxidized blood markers and oxidized membrane lipids that are indicative of excess oxidative stress [27] [28]. These patients also have sustained, elevated levels of peroxynitrite due to excess nitric oxide, which can also result in lipid peroxidation and loss of mitochondrial function as well as changes in cytokine levels that exert a positive feedback on nitric oxide production [29].…”

Section: Clinical Uses Of Membrane Lipid Replacement-fatiguementioning

confidence: 99%

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

Nicolson¹

2016

IJCM

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Section: Clinical Uses Of Membrane Lipid Replacement-fatiguementioning

confidence: 99%

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

Nicolson¹

2016

IJCM

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“…[1][2][3] Increase in oxidative stress as a result of an imbalance between free radical production and antioxidant defense has been well documented in several clinical studies. [4] In humans, strenuous exercise promotes the generation of reactive oxygen species (ROS) in the working muscle. The growing number of evidences indicates that these ROS are responsible for exercise-induced protein oxidation and contribute significantly to muscle and mental fatigue.…”

Section: Introductionmentioning

confidence: 99%

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

Pal¹,

Naika²,

Khanum³

et al. 2011

Pharmacognosy Journal

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a b s t r a c tWithania somnifera Dunal, commonly known as ashwagandha, has been used for centuries in ayurvedic medicine to increase longevity and vitality. Various groups of researchers support its polypharmaceutical uses by confirming anti-inflammatory, immuno-modulatory and antistress properties in the whole plant extract. The present investigation adds up the antioxidant assay profiling in this list. The Ashwagandha root extracts were prepared in different solvents of varied polarity in a sequential fashion. The maximum yield (5.8%) and total polyphenolic compounds (TPC, 88.58 µg GAE/mg extract) were recorded in methanolic fraction. All the extracts were screened for their potential antioxidant activities using tests such as free radical scavenging activity, metal chelation activity, hydroxyl radical scavenging activity, superoxide radical scavenging activity and hydrogen peroxide scavenging activity. Results of study showed methanolic extract as the most potent fraction and a strong correlation could be established with its TPC. Overall, the study suggests that Ashwagandha root extract could be of great use for the preparation of antioxidant rich nutraceuticles to treat various human diseases and its complications. It is quite likely that the antioxidant capacity of plant/root is one of the reasons for its established anti-stress, anti-inflammatory and immunomodulatory properties.

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“…Not surprisingly, skeletal muscles are the most investigated organ in studies designed to understand low tolerance to exercise. Oxidative stress, which other laboratories as well as our own have proposed as a possible contributor to the pathophysiology and clinical symptoms of CFS, has become a focus of this research (2)(3)(4). According to a recent study, reactive oxygen species (ROS) are not only responsible for molecular damage, but also act as important signaling molecules that modulate contractile function in both un-fatigued and fatigued skeletal muscle.…”

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confidence: 99%

Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome

Pietrangelo

Mancinelli

Toniolo

et al. 2009

Int J Immunopathol Pharmacol

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Chronic fatigue syndrome (CFS) is a disabling condition characterized by unexplained chronic fatigue that impairs normal activities. Many body systems are affected and etiology has not yet been identified. In addition to immunological and psychological aspects, skeletal muscle symptoms are prominent in CFS patients. In an effort to establish which pathways might be involved in the onset and development of muscle symptoms, we used global transcriptome analysis to identify genes that were differentially expressed in vastus lateralis muscle of female and male CFS patients. We found that the expression of genes that play key roles in mitochondrial function and oxidative balance, including superoxide dismutase 2, were altered, as were genes involved in energy production, muscular trophism and fiber phenotype determination. Importantly, the expression of a gene encoding a component of the nicotinic cholinergic receptor binding site was reduced, suggesting impaired neuromuscular transmission. We argue that these major biological processes could be involved in and/or responsible for the muscle symptoms of CFS.

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Specific oxidative alterations in vastus lateralis muscle of patients with the diagnosis of chronic fatigue syndrome

Cited by 144 publications

References 40 publications

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

Membrane Lipid Replacement: Clinical Studies Using a Natural Medicine Approach to Restoring Membrane Function and Improving Health

In-vitro studies on the antioxidant assay profiling of Withania somnifera L. (Ashwagandha) Dunal root: Part 1

Transcription Profile Analysis of Vastus Lateralis Muscle from Patients with Chronic Fatigue Syndrome

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