Specific nutritional support accelerates pressure ulcer healing and reduces wound care intensity in non-malnourished patients

Effects of an Arginine-Enriched Oral Nutritional Supplement on the Healing of Chronic Wounds in Non-Malnourished Patients; A Multicenter Case Series from the Netherlands and Hungary

“…All primary outcome measures i.e., wound healing progress, patients' compliance with and patients' rate of the specific ONS were generally positive. These findings are in line with clinical studies showing a positive effect of nutritional supplementation with additional protein, arginine and micronutrients to promote PU healing [17,18,[22][23][24][25][26][27][28][29][30]. In contrast, the findings of two studies were not in line with the findings of these studies [31,32].…”

“…Adequate nutritional support therefore plays a pivotal role in wound healing. However, based on the results of two randomized controlled trials in patients with PUs, it appears that some nutrients play an active role in wound healing independently of protein and energy provision [17,18]. In the study of van Anholt et al, the authors had used the same specific high protein, arginine-and micronutrients-enriched oral nutritional supplement (ONS) in nonmalnourished PU patients and showed beneficial effects: accelerated PU healing and decreased wound care intensity (significantly fewer dressings required per week and less time spent per week on changing the dressings), which is likely to decrease overall costs of PU treatment [17].…”

“…However, based on the results of two randomized controlled trials in patients with PUs, it appears that some nutrients play an active role in wound healing independently of protein and energy provision [17,18]. In the study of van Anholt et al, the authors had used the same specific high protein, arginine-and micronutrients-enriched oral nutritional supplement (ONS) in nonmalnourished PU patients and showed beneficial effects: accelerated PU healing and decreased wound care intensity (significantly fewer dressings required per week and less time spent per week on changing the dressings), which is likely to decrease overall costs of PU treatment [17]. The OligoElement Sore Trial of Cereda et al showed *Corresponding author: Jacques Neyens, Department of Health Services Research, Caphri -School for Public Health and Primary Care, Maastricht University, Duboisdomein 30, 6229 GT Maastricht, the Netherlands, Tel: +31653969652; E-mail: j.neyens@maastrichtuniversity.nl that the additional provision of arginine, zinc, and antioxydants in the nutritional support in malnourished PU patients improved PU healing [18].…”

“…The studies of van Anholt et al and Cereda et al have shown that adequate nutritional support by an arginine-enriched ONS significantly improved the healing of PUs [17,18]. Subsequently, the question was whether this effect also counts for diabetic foot ulcers (DFUs), arterial leg ulcers (ALUs), and venous leg ulcers (VLUs).…”

Nutritional profile of people with pressure Injuries in home care

“…10 The use of specific nutritional supplements for healing has the capacity to accelerate the healing process of pressure injuries in nonmalnourished patients, and these effects are more distinct in the first weeks. 11 However, the supplementation of a single nutrient does not demonstrate a consistent benefit. However, recent literature provides some potential benefits of concomitant supplementation of arginine, zinc, and antioxidant vitamins.…”