Specific neurophysiological mechanisms underlie cognitive inflexibility in inflammatory bowel disease

Petruo, Vanessa A.; Zeißig, Sebastian; Schmelz, Renate; Hampe, Jochen; Beste, Christian

doi:10.1038/s41598-017-14345-5

Cited by 20 publications

(20 citation statements)

References 70 publications

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“…The evidence on executive function, such as in GIDD is mixed. Some studies suggest impaired executive function associated with GIDD, (36,(50)(51)(52), whereas others do not (53,54). Some impairments in executive functioning (e.g.…”

Section: Gidd Are Associated With Changes In Cognitionmentioning

confidence: 99%

Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

Matisz¹,

Gruber²

2020

Preprint

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The brain reciprocally communicates with the rest of the body via neural, endocrine, immune, and other systems. This is crucial for coordinating the complex behavioral and physiological responses needed to cope with the many challenges of life. The Anterior Cingulate Cortex (ACC) is a key brain structure involved in assessing rewards and threats, as well as activating appropriate responses. This is a dynamic process that depends on evolving needs and challenges. Important challenges include illness or injury. These typically involve inflammation and pain, which evoke neuroinflammatory processes in the brain to drive sickness behaviours. In the short term, sickness behaviours are considered adaptive, as they promote convalescence (e.g. low mood; lethargy, fatigue, social withdrawal), and enhanced threat appraisal (e.g. anxiety) to combat increased risk/vulnerability associated with sickness. Chronic inflammation, however, appears to remodel the system to inappropriately activate threat-coping responses, resulting in depressive and/or anxious phenotypes. These mood disorders are particularly pronounced in diseases and disorders associated with gut dysfunction, which feature chronic inflammation and altered ACC function. We propose that chronic inflammation remodels ACC physiology such that it errantly predicts heightened danger based on a mental model (a.k.a ‘schema’) of the world. This evokes chronic activation of threat-coping systems, including endocrine signaling (e.g. adrenaline), and anxiety. Inflammation can be driven by brain systems involving ACC, leading to a feedback-cycle that self-reinforces pathological states. This theory accounts for a wealth of clinical and preclinical data that implicate the ACC in disorders of mood and gastrointestinal function, and reveals a key player in the gut-brain axis that may represent a novel therapeutic target.

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Section: Gidd Are Associated With Changes In Cognitionmentioning

confidence: 99%

Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

Matisz¹,

Gruber²

2020

Preprint

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“…The aforementioned brain regions are especially important for cognitive flexibility, leading to a task-switching deficit in IBD patients. Interestingly, the neurophysiological analysis did not reveal functional deficits in brain regions important for working memory, the attentional selection process and perceptual categorization 35 . Conversely, our findings of aggravated CRD performance in the used tests indirectly point to a dysfunction in those cognitive components with the exception of memory.…”

Section: Discussionmentioning

confidence: 84%

“…The pathophysiological basis for cognitive impairment in IBD patients has been investigated by Petruo et al . 35 . They have demonstrated selective functional alterations at the level of response selection in the fronto-striatal pathway.…”

Section: Discussionmentioning

confidence: 99%

Impaired neurocognitive and psychomotor performance in patients with inflammatory bowel disease

Hadjina

Živković

Matetić

et al. 2019

Sci Rep

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Limited evidence exists regarding cognitive and psychomotor function in patients with inflammatory bowel disease (IBD). Therefore, we aimed to compare the neurocognitive and psychomotor function of 60 IBD patients with 60 age/sex-matched controls. Computer-based instrument Complex Reactinometer Drenovac (CRD) was used for assessment of cognitive domains: convergent thinking (simple mathematical tasks; CRD-11), perceptive abilities (light signal position discrimination; CRD-311) and sophisticated operative thinking (complex psychomotor coordination; CRD-411). The most important analyzed parameters were total test solving time (TTTS); minimal time of particular test solving (TMIN) and total number of wrong reactions (NER). Performance in all three cognitive tests showed statistically significantly longer TTTS and TMIN in IBD patients (P < 0.05), while there was no significant difference in NER. Aforementioned findings were adjusted for BMI, age and duration of education. Our study has shown impaired neurocognitive and psychomotor function in IBD patients compared to controls, especially in mental processing speed and mental endurance of perceptive abilities, convergent thinking and complex operative thinking.

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“…In relation to cognitive flexibility,cognitive flexibility dysfunctions have been reported in IBD and IBS patients [9][10] . This result could be attributed to damage in frontal regions, both reported in patients with IBDand IBS [3][4]10 .…”

Section: Results and Future Studiesmentioning

confidence: 99%

Cognitive Dysfunctions in Inflammatory Bowel Disease and Irritable Bowel Syndrome

Bagnasco

2020

J. Medicine

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The aim of this paper is to summarize the current evidence on cognitive dysfunctions in adults with inflammatory bowel disease and inflammatory bowel syndrome.The online databases PubMed and PsycINFO were searched. All quantitative studies published in English found in the mentioned databases until December 2019 were included. Quantitative studies which did not include a control group, qualitative studies and case studies were excluded. We found seven papers about cognitive dysfunctions in IBD and IBS. Four of seven papers compare cognitive functions of patients with IBD and IBS. Three of seven studies assess cognitive functions in IBD. Three papers assessed memory, three papers studied selective attention and inhibition response, two papers assessed cognitive flexibility, one paper measured information processing speed, and one paper assessed verbal fluency. J MEDICINE JUL 2020; 21 (2) : 102-104

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Specific neurophysiological mechanisms underlie cognitive inflexibility in inflammatory bowel disease

Cited by 20 publications

References 70 publications

Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

Impaired neurocognitive and psychomotor performance in patients with inflammatory bowel disease

Cognitive Dysfunctions in Inflammatory Bowel Disease and Irritable Bowel Syndrome

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