Specific molybdenum binding to spectrin subunits

Marík, T; Kselíková, M; Bíbr, B; Lener, Jaroslav

doi:10.1002/cbf.290020107

Cited by 5 publications

(1 citation statement)

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“…Once consumed, molybdenum is transported through the gastrointestinal tract via what was hypothesised to be a passive, non-mediated process, although the exact mechanism and location of the transporters remain unclear, and recent research indicates the existence of higher-affinity molybdenum transporters [27,64]. Absorbed molybdenum is rapidly detectable in blood, with a fraction reportedly binding to α2-macroglobulins, and to the cytoskeletal protein spectrin in the erythrocyte membrane, with the majority remaining unbound as molybdate [63][64][65][66]. The molybdenum cofactor, Moco, is sensitive to oxidation, so it is postulated to exist in a protein-bound state in the cell [28].…”

Section: Bioavailability and Intake Of Molybdenummentioning

confidence: 99%

Does the Micronutrient Molybdenum Have a Role in Gestational Complications and Placental Health?

et al. 2023

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Molybdenum is an essential trace element for human health and survival, with molybdenum-containing enzymes catalysing multiple reactions in the metabolism of purines, aldehydes, and sulfur-containing amino acids. Recommended daily intakes vary globally, with molybdenum primarily sourced through the diet, and supplementation is not common. Although the benefits of molybdenum as an anti-diabetic and antioxidant inducer have been reported in the literature, there are conflicting data on the benefits of molybdenum for chronic diseases. Overexposure and deficiency can result in adverse health outcomes and mortality, although physiological doses remain largely unexplored in relation to human health. The lack of knowledge surrounding molybdenum intake and the role it plays in physiology is compounded during pregnancy. As pregnancy progresses, micronutrient demand increases, and diet is an established factor in programming gestational outcomes and maternal health. This review summarises the current literature concerning varied recommendations on molybdenum intake, the role of molybdenum and molybdoenzymes in physiology, and the contribution these play in gestational outcomes.

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Section: Bioavailability and Intake Of Molybdenummentioning

confidence: 99%