Specific long non-coding RNAs response to occupational PAHs exposure in coke oven workers

Gao, Chen; He, Zhini; Li, Jie; Li, Xiao; Bai, Quan; Zhang, Zhengbao; Zhang, Xiao; Wang, Shan; Xiao, Xinhua; Wang, Fangping; Yan, Yan; Li, Daochuan; Chen, Liping; Zeng, Xiao‐Wen; Xiao, Yongmei; Dong, Guang‐Hui; Zheng, Yuxin; Wang, Qing; Chen, Wen

doi:10.1016/j.toxrep.2015.12.011

Cited by 33 publications

(25 citation statements)

References 50 publications

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“…The expression of MALAT1 in the cerebellum, hippocampus, and brain stem of human alcoholics is significantly increased, which may be involved in the chronic injury of alcohol to brain tissue (Kryger et al, ). MALAT1 expression in coke oven workers is also increased after occupational exposure to polycyclic aromatic hydrocarbons (PAHs), and MALAT1 might be involved in response to PAHs‐induced DNA damage (Gao et al, ). Arsenite may induce the upregulation of MALAT1, which in turn increases glycolysis by stabilizing hypoxia‐inducible factor 1α (HIF‐1α) expression (Luo et al, 2016).…”

Section: Role Of Malat1 In Cellular Stress Responsesmentioning

confidence: 99%

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

Chen

Huang

et al. 2018

Journal Cellular Physiology

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Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long noncoding RNA whose transcript is around 8 kb in length. As an important stress response molecule, MALAT1 can be expressed differently under stress conditions, such as hypoxia, high glucose, hydrogen peroxide, ultraviolet irradiation, infection, and chemical stimulation. MALAT1 is involved in regulating multiple cell behaviors, such as proliferation, apoptosis, differentiation, migration, epithelial-mesenchymal transition, autophagy, and morphological maintenance. Extensive evidence show that MALAT1 plays critical roles in the physiopathological process of embryo implantation, angiogenesis, tissue inflammation, tumor progression, liver fibrosis, cardiovascular remodeling, and diabetes progression by regulating gene transcription, forming RNA-protein complexes with proteins as a structural component, regulating protein activity, assisting protein localization, mediating epigenetic changes, or by acting as a competing endogenous RNA. Furthermore, MALAT1 can affect the sensitivity of chemotherapy and radiotherapy; therefore, it could be used as a potential drug target for chemotherapy and radiotherapy sensitization. The levels of MALAT1 are reported to be overexpressed in most tumor tissues or sera, and the expression levels of MALAT1 often affect the tumor size, stage, lymph node metastasis, and distant invasion. Therefore, MALAT1 can be used as a biomarker for early diagnosis, severity assessment, or prognostic assessment. This review outlines the current understanding of the biological role and function of MALAT1. In the meantime, we have summarized the mechanisms involved in the reulation of MALAT1 expression and the mechanisms by which MALAT1 regulates the physiological and pathological processes.

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Section: Role Of Malat1 In Cellular Stress Responsesmentioning

confidence: 99%

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

Chen

Huang

et al. 2018

Journal Cellular Physiology

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“…However, all these results further confirm the presence of PAHs in trace amount irrespective of medium. Study on the health effects of PAHs external and internal occupational exposure on DNA damage and RNAs response in coke oven workers [ 38 ]; and in smoked fish species from markets in Southern Nigeria have also been investigated [ 39 ]. High exposure to PAHs could lead to lower Intelligent Quotient (IQ) and childhood asthma [ 40 ].…”

Section: Resultsmentioning

confidence: 99%

Determination of polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs) in some personal care products in Nigeria

et al. 2018

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“…Other than MEG3, dysregulations of many lncRNAs in lung cancer have been identified and summarized by Khandelwal et al [32,106], of which some have been shown to be associated with occupational PAH (Polycyclic Aromatic Hydrocarbon) exposures in coke oven workers, such as HOTAIR, TUG1, MALAT1 and GAS5 [107]. Cadmium was also found to induce the expression of lncRNA, ENST00000414355, to modulate DNA damage and repair in 16HBE cells.…”

Section: Tumor Suppressor Gene and Proto-oncogene Alterationsmentioning

confidence: 99%

The Role of Non-Coding RNAs Involved in Nickel-Induced Lung Carcinogenic Mechanisms

Zhu

Chen

et al. 2019

Inorganics

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Nickel is a naturally occurring element found in the Earth’s crust and an International Agency for Research on Cancer (IARC)-classified human carcinogen. While low levels found in the natural environment pose a minor concern, the extensive use of nickel in industrial settings such as in the production of stainless steel and various alloys complicate human exposure and health effects. Notably, interactions with nickel macromolecules, primarily through inhalation, have been demonstrated to promote lung cancer. Mechanisms of nickel-carcinogenesis range from oxidative stress, DNA damage, and hypoxia-inducible pathways to epigenetic mechanisms. Recently, non-coding RNAs have drawn increased attention in cancer mechanistic studies. Specifically, nickel has been found to disrupt expression and functions of micro-RNAs and long-non-coding RNAs, resulting in subsequent changes in target gene expression levels, some of which include key cancer genes such as p53, MDM2, c-myc, and AP-1. Non-coding RNAs are also involved in well-studied mechanisms of nickel-induced lung carcinogenesis, such as the hypoxia-inducible factor (HIF) pathway, oxidative stress, DNA damage and repair, DNA hypermethylation, and alterations in tumor suppressors and oncogenes. This review provides a summary of the currently known epigenetic mechanisms involved in nickel-induced lung carcinogenesis, with a particular focus on non-coding RNAs.

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Specific long non-coding RNAs response to occupational PAHs exposure in coke oven workers

Cited by 33 publications

References 50 publications

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

Functions and regulatory mechanisms of metastasis‐associated lung adenocarcinoma transcript 1

Determination of polycyclic aromatic hydrocarbons (PAHs) and organochlorine pesticides (OCPs) in some personal care products in Nigeria

The Role of Non-Coding RNAs Involved in Nickel-Induced Lung Carcinogenic Mechanisms

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