EA Georgakopoulou, K Tsimaratou, K Evangelou, Marcos-PJ Fernandez, V Zoumpourlis, IP Trougakos, D Kletsas, J Bartek, M Serrano, VG Gorgoulis
Abstract:There is shortage of extensive clinicopathologic studies of cellular senescence because the most reliable senescence biomarker, the detection of Senescence-Associated-beta-galactosidase activity (SA-β-gal), is inapplicable in archival material and requires snap-frozen tissues. We validated the histochemical Sudan-Black-B (SBB) specific stain of lipofuscin, an aggregate of oxidized proteins, lipids and metals, known to accumulate in aged tissues, as an additional reliable approach to detect senescent cells inde…
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