“…SYK is required for signaling and immune cell activation via the B-cell antigen receptor (BCR), activating fragment crystallizable receptors, and integrins (Mocsai et al, 2010). Genetic studies demonstrate SYK is required for certain inflammatory and autoimmune mechanisms in mice (Colonna et al, 2010;Jakus et al, 2010;Elliott et al, 2011;Wex et al, 2011;Ozaki et al, 2012), a concept that has been reproduced pharmacologically in cellular and animal models (Braselmann et al, 2006;Pine et al, 2007;Coffey et al, 2012). Phase II clinical trials of SYK inhibition by R788 [(6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-3-oxo-2,3-dihydropyrido [3,2-b][1,4]oxazin-4-yl)methyl dihydrogen phosphate] demonstrated efficacy in B-cell non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) (Friedberg et al, 2010), rheumatoid arthritis (RA) (Weinblatt et al, 2008(Weinblatt et al, , 2010, and immune thrombocytopenia (Podolanczuk et al, 2009).…”