Specific IgE reactivity to Tri a 36 in children with wheat food allergy

Baar, Alexandra; Pahr, Sandra; Constantin, Claudia; Giavi, Stavroula; Manoussaki, Alkisti; Papadopoulos, Nikolaos G.; Ebner, Christof; Mari, Adriano; Vrtala, Susanne; Valenta, Rudolf

doi:10.1016/j.jaci.2013.10.044

Cited by 21 publications

(19 citation statements)

References 10 publications

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“…104,107,113,146 The IgE-binding epitopes for these allergens were identified in patients with wheat allergy 104,107 and in addition, the sequences of QQPFP and PQQPF in gliadin were epitopes in atopic dermatitis-related wheat allergy. 149 LMW-GS (Tri a 36) was identified as an allergen that induces wheat food allergy 123,150,151 and WDEIA 152 in European patients. There are several types of LMW-GS encoded by genes located on group 1 chromosomes at the Glu-A3, Glu-B3, and Glu-D3 loci, 153 and patients with wheat allergy exhibited IgE-reactivity to different LMW-GS.…”

Section: Water/salt-soluble Wheat Allergensmentioning

confidence: 99%

Common food allergens and their IgE-binding epitopes

Matsuo

Yokooji

Taogoshi

2015

Allergology International

195

123

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Food allergy is an adverse immune response to certain kinds of food. Although any food can cause allergic reactions, chicken egg, cow's milk, wheat, shellfish, fruit, and buckwheat account for 75% of food allergies in Japan. Allergen-specific immunoglobulin E (IgE) antibodies play a pivotal role in the development of food allergy. Recent advances in molecular biological techniques have enabled the efficient analysis of food allergens. As a result, many food allergens have been identified, and their molecular structure and IgE-binding epitopes have also been identified. Studies of allergens have demonstrated that IgE antibodies specific to allergen components and/or the peptide epitopes are good indicators for the identification of patients with food allergy, prediction of clinical severity and development of tolerance. In this review, we summarize our current knowledge regarding the allergens and IgE epitopes in the well-researched allergies to chicken egg, cow's milk, wheat, shrimp, and peanut.

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Section: Water/salt-soluble Wheat Allergensmentioning

confidence: 99%

Common food allergens and their IgE-binding epitopes

Matsuo

Yokooji

Taogoshi

2015

Allergology International

195

123

View full text Add to dashboard Cite

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“…28 For example, Sirvent et al 29 cleverly noted that persons with negative test results to kiwifruit who yet react might be responding to allergens in the small crunchy seeds of the fruit rather than the pulp. They elegantly proved this to be the case, identifying 2 relevant seed allergens that might be needed to improve diagnosis.…”

Section: Diagnosismentioning

confidence: 99%

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014

Sicherer

Leung

2015

Journal of Allergy and Clinical Immunology

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This review highlights some of the research advances in anaphylaxis; hypersensitivity reactions to foods, drugs, and insects; and allergic skin diseases that were reported in the Journal in 2014. Studies on food allergy suggest worrisomely high rates of peanut allergy and food-induced anaphylaxis-related hospitalizations. Evidence is mounting to support the theory that environmental exposure to peanut, such as in house dust, especially with an impaired skin barrier attributed to atopic dermatitis (AD) and loss of function mutations in the filaggrin gene, is a risk factor for sensitization and allergy. Diagnostic tests are improving, with early studies suggesting the possibility of developing novel cellular tests with increased diagnostic utility. Treatment trials continue to show the promise and limitations of oral immunotherapy, and mechanistic studies are elucidating pathways that might define the degree of efficacy of this treatment. Studies have also provided insights into the prevalence and characteristics of anaphylaxis and insect venom allergy, such as suggesting that baseline platelet-activating factor acetylhydrolase activity levels are related to the severity of reactions. Advances in drug allergy include identification of HLA associations for penicillin allergy and a microRNA biomarker/mechanism for toxic epidermal necrolysis. Research identifying critical events leading to skin barrier dysfunction and the polarized immune pathways that drive AD have led to new therapeutic approaches in the prevention and management of AD.

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“…59 A recent European study reported that IgE to the wheat component rTri a 36 accurately identified more patients with true wheat allergy than did IgE to omega-5 gliadin. 60 While the different results reported from these studies could result from different sensitization patterns in different geographic locations, they also likely reflect different inclusion criteria and other differences in the populations tested.…”

Section: Emerging Diagnostic Testsmentioning

confidence: 89%

Optimizing the Diagnosis of Food Allergy

Kattan

Sicherer

2015

Immunology and Allergy Clinics of North America

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SYNOPSIS Making an accurate diagnosis when evaluating a patient with a possible food allergy is particularly important both to avoid unnecessary dietary restrictions and to prevent life threatening reactions. The testing modalities used routinely in clinical practice, including skin prick testing and food specific IgE levels, have limited accuracy, and a physician-supervised oral food challenge is often required to make a definitive diagnosis. Given the labor-intensive nature of this test and the risk of inducing an allergic reaction, researchers have investigated a number of alternative diagnostic modalities to improve the accuracy of food allergy testing. Testing for IgE antibodies to particular protein components in foods has already shown promise to improve diagnostics and has entered clinical practice. Additional modalities are under study that show potential including epitope binding, T cell studies, basophil activation and others.

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Specific IgE reactivity to Tri a 36 in children with wheat food allergy

Cited by 21 publications

References 10 publications

Common food allergens and their IgE-binding epitopes

Common food allergens and their IgE-binding epitopes

Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2014

Optimizing the Diagnosis of Food Allergy

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