Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma

Bachert, Claus; Steen, Kristel Van; Zhang, Nan; Holtappels, Gabriële; Cattaert, Tom; Maus, Bärbel; Buhl, Roland; Taube, Christian; Korn, Stephanie; Kowalski, Marek L.; Bousquet, Jean; Howarth, Peter H.

doi:10.1016/j.jaci.2012.05.012

Cited by 170 publications

(182 citation statements)

References 29 publications

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“…Thus, the total serum IgE can be used as an indicator to predict the outcome of asthma therapy. A previous study indicated that the IgE levels were positively correlated with the severity of asthma (Bachert et al 2012). This relationship was also supported by our study in that, after ICS therapy, the level of IgE decreased following remission of asthma.…”

Section: Discussionsupporting

confidence: 91%

Serum Eosinophil Cationic Protein Is a Useful Marker for Assessing the Efficacy of Inhaled Corticosteroid Therapy in Children with Bronchial Asthma

Guo

Sun

Wang

et al. 2017

Tohoku J. Exp. Med.

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Bronchial asthma (BA) is a chronic inflammatory disorder of airways for which the effective therapies include inhaled corticosteroids (ICS) and short-acting β 2-adrenoreceptor agonist (SABA). Serum eosinophil cationic protein (ECP) has been reported to reflect the degree of airway inflammation. We, therefore, explored the implication of serum ECP in assessing the efficacy of ICS therapy in BA children. Our prospective randomized control study enrolled 126 BA children and 78 healthy children (the control group). The BA patients were randomly assigned as two groups; 59 children were treated with ICS, twice a day, for three months and 67 patients received SABA inhalation only if necessary. After the 3-month therapy, the serum levels of ECP, endothelin-1, and nitric oxide and the eosinophil percentage (EOS%) in induced sputum were significantly lower in the ICS group, compared with the SABA group, but were still higher than the control group (all P < 0.05). The forced expiratory volume (FEV1%pred) and forced vital capacity (FEV1/FVC) were improved to the levels of the control group after therapy. Pearson correlation analysis presented that higher serum ECP levels were associated with higher EOS% in serum and with lower pulmonary function indices (FEVl%pred and FEV1/FVC). Importantly, the ICS group exhibited higher quality of life scores and lower symptom scores compared with the SABA group (all P < 0.05). ROC results revealed the diagnostic efficiency of serum ECP levels on the efficacy of ICS. In conclusion, measuring serum ECP levels is helpful for assessing the efficacy of ICS therapy in BA children.

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Section: Discussionsupporting

confidence: 91%

Serum Eosinophil Cationic Protein Is a Useful Marker for Assessing the Efficacy of Inhaled Corticosteroid Therapy in Children with Bronchial Asthma

Guo

Sun

Wang

et al. 2017

Tohoku J. Exp. Med.

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“…Whereas SE-IgE in CRSwNP patients often is undetectable in serum, 919 it was associated with asthma in a Europe-wide epidemiological study 920 and associated with severe, often nonatopic late-onset asthma. 921,922 Staphylococcal enterotoxin IgE antibodies, but not IgE against inhalant allergens, were found to be risk factors for severe asthma, hospitalization, and oral corticosteroid use, as well as limitations in lung function. 922 In a study investigating the immune profiles of recurrent vs nonrecurrent polyp disease at the first surgery, SE-IgE was, with other factors (total IgE, ECP, IL-5), significantly increased in recurrent polyps, whereas IFN-γ was increased in nonrecurrent CRSwNPs.…”

Section: Viiib Crswnp: Comorbid Asthmamentioning

confidence: 99%

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

Orlandi

Kingdom

Hwang

et al. 2016

Int Forum Allergy Rhinol

554

888

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Background:The body of knowledge regarding rhinosinusitis (RS) continues to expand, with rapid growth in number of publications, yet substantial variability in the quality of those presentations. In an effort to both consolidate and critically appraise this information, rhinologic experts from around the world have produced the International Consensus Statement on Allergy and Rhinology: Rhinosinusitis (ICAR:RS). Methods:Evidence-based reviews with recommendations (EBRRs) were developed for scores of topics, using previously reported methodology. Where existing evidence was insufficient for an EBRR, an evidence-based review (EBR) was produced. The sections were then synthesized and the entire manuscript was then reviewed by all authors for consensus. Results:The resulting ICAR:RS document addresses multiple topics in RS, including acute RS (ARS), chronic RS (CRS) with and without nasal polyps (CRSwNP and CRSsNP), recurrent acute RS (RARS), acute exacerbation of CRS (AE-CRS), and pediatric RS. Conclusion:As a critical review of the RS literature, ICAR:RS provides a thorough review of pathophysiology and evidence-based recommendations for medical and surgical treatment. It also demonstrates the significant gaps in our understanding of the pathophysiology and optimal management of RS. Too o en the foundation upon which these recommendations are based is comprised of lowerlevel evidence. It is our hope that this summary of the evidence in RS will point out where additional research efforts may be directed. C 2016 ARS-AAOA, LLC. Key Words:rhinosinusitis; chronic rhinosinusitis; acute rhinosinusitis; recurrent acute rhinosinusitis; evidence-based medicine; systematic review; endoscopic sinus surgery List of Abbreviations Used

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“…There are many different studies proved that S. aureus and its toxins have major role in asthma as following cited by (Jarvis et al, 2015). Bachert et al, (2012), found enterotoxin IgE positivity was significantly greater in patients with severe asthma than in healthy control subjects so that they proved SE IgE antibodies but not IgE against inhalant allergens are risk factors for asthma severity and hypothesize that the presence of enterotoxin IgE in serum indicates the involvement of Staphylococcal super antigens in pathophysiology of patient with severe asthma. Yang et al, (2005), proved that the asthma is closely related with sinusitis by taking 85 asthmatic patients they found 51 of 85 patients with high serum anti staphylococcus enterotoxin B antibody before treatment obtained satisfactory results for both sinusitis and asthma.…”

Section: Resultsmentioning

confidence: 97%

“…Also found in this study also found all asthmatic patients (+ve) with nasal Staphylococcal infection had nasal polyp, and that is already because of the Staph. aureus is main causative agent for nasal polyp (Bachert et al, 2012) also there was highly significant relationship between Staph. aureus infection and IFNγ polymorphism A/T at 874 position in case of asthmatic patients (asthmatic patients +ve with Staph.…”

Section: Resultsmentioning

confidence: 98%

See 1 more Smart Citation

The Relationship between Staphylococcus aureus Infection and Some Asthma Markers As (IL – 4, IL – 10, IFN γ, IgE and FOXP3) in Asthmatic Patients

Al-Hilali¹,

Atta²

2016

Int.J.Curr.Microbiol.App.Sci

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Specific IgE against Staphylococcus aureus enterotoxins: An independent risk factor for asthma

Cited by 170 publications

References 29 publications

Serum Eosinophil Cationic Protein Is a Useful Marker for Assessing the Efficacy of Inhaled Corticosteroid Therapy in Children with Bronchial Asthma

Serum Eosinophil Cationic Protein Is a Useful Marker for Assessing the Efficacy of Inhaled Corticosteroid Therapy in Children with Bronchial Asthma

International Consensus Statement on Allergy and Rhinology: Rhinosinusitis

The Relationship between Staphylococcus aureus Infection and Some Asthma Markers As (IL – 4, IL – 10, IFN γ, IgE and FOXP3) in Asthmatic Patients

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