Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients

Leyrolle, Quentin; Cserjési, Renáta; Mulders, Maria D.G.H.; Zamariola, Giorgia; Hiel, Sophie; Gianfrancesco, Marco; Rodriguez, Julie; Portheault, Daphnée; Amadieu, Camille; Leclercq, Sophie; Bindels, Laure B.; Neyrinck, Audrey M.; Cani, Patrice D.; Kärkkäinen, Olli; Hanhineva, Kati; Lanthier, Nicolas; Tréfois, Pierre; Paquot, Nicolas; Cnop, Miriam; Thissen, Jean‐Paul; Klein, Olivier; Luminet, Olivier; Delzenne, Nathalie M.

doi:10.1016/j.clnu.2020.09.025

Cited by 42 publications

(23 citation statements)

References 80 publications

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“…Very recently, Leyrolle and colleagues have examined the biological and psychiatric profile of obese patients with and without binge eating disorders through non-targeted multi-omics approaches. The authors suggest the potential role of certain GM layouts (i.e., with enrichment of Bifidobacterium and Anaerostipes , and depletion of Akkermansia and Intestimonas ) and/or plasma metabolites (i.e., food contaminants and food derived-metabolites) as drivers or biomarkers of binge eating disorders [ 19 ]. However, to our knowledge, no other studies have examined the relationship between GM and FA and, in general, very little information is available on GM functionality in uncontrolled eating behavior and obesity.…”

Section: Introductionmentioning

confidence: 99%

Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior

Barone

Garelli

Rampelli

et al. 2022

BMC Med

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Background Obesity and related co-morbidities represent a major health challenge nowadays, with a rapidly increasing incidence worldwide. The gut microbiome has recently emerged as a key modifier of human health that can affect the development and progression of obesity, largely due to its involvement in the regulation of food intake and metabolism. However, there are still few studies that have in-depth explored the functionality of the human gut microbiome in obesity and even fewer that have examined its relationship to eating behaviors. Methods In an attempt to advance our knowledge of the gut-microbiome-brain axis in the obese phenotype, we thoroughly characterized the gut microbiome signatures of obesity in a well-phenotyped Italian female cohort from the NeuroFAST and MyNewGut EU FP7 projects. Fecal samples were collected from 63 overweight/obese and 37 normal-weight women and analyzed via a multi-omics approach combining 16S rRNA amplicon sequencing, metagenomics, metatranscriptomics, and lipidomics. Associations with anthropometric, clinical, biochemical, and nutritional data were then sought, with particular attention to cognitive and behavioral domains of eating. Results We identified four compositional clusters of the gut microbiome in our cohort that, although not distinctly associated with weight status, correlated differently with eating habits and behaviors. These clusters also differed in functional features, i.e., transcriptional activity and fecal metabolites. In particular, obese women with uncontrolled eating behavior were mostly characterized by low-diversity microbial steady states, with few and poorly interconnected species (e.g., Ruminococcus torques and Bifidobacterium spp.), which exhibited low transcriptional activity, especially of genes involved in secondary bile acid biosynthesis and neuroendocrine signaling (i.e., production of neurotransmitters, indoles and ligands for cannabinoid receptors). Consistently, high amounts of primary bile acids as well as sterols were found in their feces. Conclusions By finding peculiar gut microbiome profiles associated with eating patterns, we laid the foundation for elucidating gut-brain axis communication in the obese phenotype. Subject to confirmation of the hypotheses herein generated, our work could help guide the design of microbiome-based precision interventions, aimed at rewiring microbial networks to support a healthy diet-microbiome-gut-brain axis, thus counteracting obesity and related complications.

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Section: Introductionmentioning

confidence: 99%

Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior

Barone

Garelli

Rampelli

et al. 2022

BMC Med

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“…Growing evidence demonstrates that A. muciniphila can effectively improve metabolic disorders and is therefore regarded as a promising “next generation of beneficial microorganisms” [ 76 ]. Our findings also indicated that the abundance of A. muciniphila is indeed associated with many diseases, metabolic diseases such as type 2 diabetes (T2D) [ 77 ], obesity [ 78 – 80 ], Binge eating disorder (BED) [ 81 ] and psoriasis [ 82 ], which indicates that microecological agents may become an important therapeutic approach in the future.…”

Section: Discussionmentioning

confidence: 80%

Comprehensive bibliometric and visualized analysis of research on fecal microbial transplantation published from 2000 to 2021

Chen

et al. 2022

BioMed Eng OnLine

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Background Fecal microbial transplantation has emerged in recent years as a method of treating disease by rebuilding the intestinal flora. However, few bibliometric analyses have systematically studied this area of research. We aimed to use bibliometric analysis to visualize trends and topical research in fecal microbial transplantation to help provide insight into future trends in clinical and basic research. Materials and methods Articles and reviews related to fecal microbial transplantation were collected from the Web of Science Core Collection. Significant information associated with this field was visually analyzed by using Biblioshiny and CtieSpace software. Results A total of 3144 articles and overviews were included. The number of publications related to fecal microbial transplantation significantly increased yearly. These publications mainly came from 100 countries, led by the US and China, and 521 institutions. The most prolific and influential author is KHORUTS A. The main disciplines and application fields of fecal microbial transplantation included molecular /biology/immunology and medicine/clinical medicine, and the research foundation of fecal microbial transplantation was molecular /biology/genetics and health/nursing/medicine. An alluvial flow visualization showed several landmark articles. New developments were identified in terms of reference and keyword citation bursts. Data analysis showed that different FMT preparation and delivery methods gradually appeared as research hotspots. The main research keywords in the last 3 years were chain fatty acids, Akkermansia muciniphila, and insulin sensitivity, other keywords were current and developing research fields. Conclusion Research on fecal microbial transplantation is flourishing and many new applications of fecal microbial transplantation are emerging. Microbial metabolites such as short-chain fatty acids and the microbiota–gut–brain axis have become the focus of current research and are future research trends.

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“…Anaerostipes is closely related to eating habits and inflammation in obese people, but the precise mechanism is unclear [ 103 , 111 ]. It is reported that by promoting propionate formation via inositol or phytate, anaerostipes may lower the risk of metabolic disorders [ 112 ].…”

Section: Discussionmentioning

confidence: 99%

The Hypolipidemic Effect of Hawthorn Leaf Flavonoids through Modulating Lipid Metabolism and Gut Microbiota in Hyperlipidemic Rats

Weng

Cui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Objective. The purpose of this study was to explore the potential mechanisms of the lipid-regulating effects and the effect on modulating the gut microbiota of hawthorn leaf flavonoids (HLF) in the high-fat diet-induced hyperlipidemic rats. Methods. The hypolipidemic effect of HLF was investigated in the high-fat diet-induced hyperlipidemic rats. The action targets of HLF in the treatment of hyperlipidemia were predicted by network pharmacology and KEGG enrichment bubble diagram, which were verified by the test of western blotting. Meanwhile, we used 16S rRNA sequencing to evaluate the effects of HLF on the microbes. Results. The results of animal experiments showed that HLF could reduce the body weight and regulate the levels of serum lipid in high-fat diet (HFD) rats. Meanwhile, for the related targets of cholesterol metabolism, HLF could significantly upregulate the expression of LDLR, NR1H3, and ABCG5/ABCG8; reduce the expression of PCSK9; and increase the level of CYP7A1 in the intestinal tissue, whereas cholesterol biosynthetic protein expressions including HMGCR and SCAP were lowered by HLF. In addition, HLF increased the activities of plasma SOD, CAT, and GSH-Px and decreased the levels of Casp 1, NLRP3, IL-1β, IL-18, and TNF-α, improving the degree of hepatocyte steatosis and inflammatory infiltration of rats. Notably, HLF significantly regulated the relative abundance of major bacteria such as g_Lactobacillus, g_Anaerostipes, g_[Eubacterium]_hallii_group, g_Fusicatenibacter, g_Akkermansia, and g_Collinsella. Synchronously, we found that HLF could regulate the disorder of plasma HEPC and TFR levels caused by HFD. Conclusion. This study demonstrates that HLF can regulate metabolic hyperlipidemia syndromes and modulate the relative abundance of major bacteria, which illustrated that it might be associated with the modulation of gut microbiota composition and metabolites.

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Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients

Cited by 42 publications

References 80 publications

Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior

Multi-omics gut microbiome signatures in obese women: role of diet and uncontrolled eating behavior

Comprehensive bibliometric and visualized analysis of research on fecal microbial transplantation published from 2000 to 2021

The Hypolipidemic Effect of Hawthorn Leaf Flavonoids through Modulating Lipid Metabolism and Gut Microbiota in Hyperlipidemic Rats

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