Specific fixation of bovine brain and retinal acidic and basic fibroblast growth factors to mouse embryonic eye basement membranes

Jeanny, Jean‐Claude; Fayein, N.A.; Moenner, Michel; Chevallier, Bruno; Barritault, Denis; Courtois, Yves

doi:10.1016/0014-4827(87)90251-5

Cited by 125 publications

(56 citation statements)

References 32 publications

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“…This is reinforced by the fact that heparin or a 2 MNaCl wash decreases the binding. Such results are similar to those observed on the mouse embryonic eye basement membrane (Jeanny et al, 1987) and on rabbit cornea1 epithelial wounds (Assouline et ab, 1989).…”

Section: Discussionsupporting

confidence: 89%

Acidic fibroblast growth factor is present in regenerating limb blastemas of axolotls and binds specifically to blastema tissues

Boilly

Cavanaugh²,

Thomas

et al. 1991

Developmental Biology

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Section: Discussionsupporting

confidence: 89%

Acidic fibroblast growth factor is present in regenerating limb blastemas of axolotls and binds specifically to blastema tissues

Boilly

Cavanaugh²,

Thomas

et al. 1991

Developmental Biology

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“…Similar co-localisation of HSPG and FGF have been demonstrated in postnatal rat lenses . Previous studies (Jeanny et al, 1987;Fayein et al, 1990) have also shown that exogenous bFGF and aFGF will bind to heparitinase-sensitive, low affinity binding sites in ocular basement membranes at various stages of ocular development. This interaction between HSPG and FGF may have ramifications for lens mor- Fig.…”

Section: Discussionmentioning

confidence: 92%

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

Iongh

McAvoy

1993

Developmental Dynamics

110

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As part of an investigation into the role FGF in lens development, we have studied the distribution of both aFGF and bFGF during eye morphogenesis from embryonic days 10 to 18 (E10–E18) in the rat. For aFGF, reactivity was found only in ectoderm at E10, prior to contact between the optic vesicle and presumptive lens ectoderm. During lens placode formation (E11) there was a transient, diffuse reactivity for aFGF in anterior optic vesicle cells directly apposed to the labelled ectoderm of the lens placode. At E12 the diffuse reactivity of the lens placode had changed to a discrete localisation along the basolateral surfaces of differentiating cells in the lens pit. Similar reactivity was associated with neuroblasts along the inner margin of the optic cup. At the early lens vesicle stage (E13) the baso‐lateral aFGF‐like reactivity associated with elongating lens cells was more intense and extensive. From the late lens vesicle stage (E14) to E18, reactivity in the lens was increasingly restricted to the equatorial regions which incorporate the germinative and transitional zones. From E16 to E18, aFGF‐like reactivity in the retina was predominantly localised in the peripheral regions corresponding to the developing ciliary body and iris and in the central retina associated with ganglion cell axons. For bFGF, weak reactivity was detectable as early as E13 in the developing lens capsule and increased in intensity during lens development with the posterior capsule reacting more intensely than the anterior capsule. Retinal bFGF‐like reactivity was first detected at E14, associated with differentiating ganglion cells in the central retina. From E16 to E18 the retinal ganglion cells showed increasing reactivity and the pattern of reactivity followed the centro‐peripheral pattern of retinal development. Thus reactivity for aFGF is first detected in presumptive lens ectoderm and subsequently in optic vesicle cells which are closely associated with lens ectoderm. This raises the possibility that aFGF may be involved in inductive interactions between presumptive lens ectoderm and optic vesicle. Furthermore the localisation patterns established for both aFGF and bFGF during lens and retina morphogenesis suggest an important role for FGF in regulating their morphogenesis and growth. © 1993 Wiley‐Liss, Inc.

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“…For example, the binding a nity of FGFs to heparin, which is a highly sulfated GAG, is greater than that to heparan-sulfate, a GAG that is less sulfated (Templeton, 1992). However, the high isoelectric point, by itself, is insu cient to explain the binding, because PDGF, with an isoelectric point similar to b-FGF, does not localize to anionic heparan sulfate sites on the basement membrane of the eye, whereas a-FGF and b-FGF do bind to the same sites (Jeanny et al, 1987).…”

Section: Discussionmentioning

confidence: 99%

VEGF165 requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells

et al. 2001

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Specific fixation of bovine brain and retinal acidic and basic fibroblast growth factors to mouse embryonic eye basement membranes

Cited by 125 publications

References 32 publications

Acidic fibroblast growth factor is present in regenerating limb blastemas of axolotls and binds specifically to blastema tissues

Acidic fibroblast growth factor is present in regenerating limb blastemas of axolotls and binds specifically to blastema tissues

Spatio‐temporal distribution of acidic and basic FGF indicates a role for FGF in rat lens morphogenesis

VEGF165 requires extracellular matrix components to induce mitogenic effects and migratory response in breast cancer cells

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