Specific features of lecithin oxidation in organic solvents

Mengele, E. A.; Kartasheva, Z. S.; Плащина, И. Г.; Касаикина, О. Т.

doi:10.1134/s1061933x08060112

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…Purified solid lecithins require storage in tightly closed containers at subfreezing temperatures. Lecithins show chemical incompatibility with esterases owing to hydrolysis [ (12,133).] Pluronic® F127 has proven to be a promising protectant for proteins such as lysozymes in spray-dried and crystallized forms, potentially overcoming the instabilities associated with other surfactants [ (134).…”

Section: Surfactantsmentioning

confidence: 99%

Excipient Stability in Oral Solid Dosage Forms: A Review

et al. 2017

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The choice of excipients constitutes a major part of preformulation and formulation studies during the preparation of pharmaceutical dosage forms. The physical, mechanical, and chemical properties of excipients affect various formulation parameters, such as disintegration, dissolution, and shelf life, and significantly influence the final product. Therefore, several studies have been performed to evaluate the effect of drug-excipient interactions on the overall formulation. This article reviews the information available on the physical and chemical instabilities of excipients and their incompatibilities with the active pharmaceutical ingredient in solid oral dosage forms, during various drug-manufacturing processes. The impact of these interactions on the drug formulation process has been discussed in detail. Examples of various excipients used in solid oral dosage forms have been included to elaborate on different drug-excipient interactions.

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Section: Surfactantsmentioning

confidence: 99%

Excipient Stability in Oral Solid Dosage Forms: A Review

et al. 2017

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“…Unsaturated fatty acid residues of PCh are susceptible to oxidation similar to nonpolar unsaturated lipids. In organic solvents, lecithins are easily dissolved to yield compact reverse micelles (5–8 nm) . In aqueous solutions, lecithin forms multilamellar liposomes or vesicles under the action of ultrasound dispersion .…”

Section: Micellar Effects In Liquid‐phase Oxidationmentioning

confidence: 99%

Unusual antioxidant effects in multiphase and complex systems

Касаикина

Krugovov

Mengele

2017

Euro J Lipid Sci & Tech

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In recent years, a number of studies have produced evidence that the multiphase and boundary effects in the systems containing surfactants, have to be taken into account for the development of innovative antioxidant technologies of lipid containing products. This report presents some unusual antioxidant effects, which occur only in multiphase complex systems due to the influence of surfactants (S).Hydroperoxides (LOOH), the primary oxidation products, form mixed micelles with surfactants (S) {nLOOHmS}. In the case of cationic surfactants (S + ), an accelerated hydroperoxide decomposition resulted in free radical generation occurs. Moderate magnetic field affects the free radical escape from mixed micelles {nLOOHmS + } into bulk solution; it can result in inhibiting of lipid oxidation in micellar system. Nonionic S can inhibit the catalyzed lipid oxidation by solubilization of the hydrophilic catalyst and spatial separation of the catalyst and substrate. Anionic surfactants alkylsulfates and alkylphosphates are effective antioxidants for alkylaromatic hydrocarbons due to the catalytic heterolytic decomposition of hydroperoxides into carbonyl compound and phenol which scavenges peroxyl radicals.

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“…The primary products of PL oxidation are mainly isomeric hydroperoxides [9,12,[57][58][59]. Lecithins are easily dissolved in organic solvents to yield compact reverse micelles [60,61].…”

Section: Phospholipid Oxidationmentioning

confidence: 99%