Specific features of immunological reactions in elderly and young patients with exacerbation of schizophrenia

Klyushnik, T P; Barkhatova, A. N.; Sheshenin, V.; Андросова, Л В; Zozulya, S A; Otman, I.; Pochueva, V.

doi:10.17116/jnevro202112102153

Cited by 12 publications

(6 citation statements)

References 15 publications

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“…Thus, group 2, where psychosis developed in patients more than two months after COVID-19, showed increases in blood activity of both LE (p < 0.05) and its inhibitor α1-PI (p < 0.001). Increases in the activity of acute-phase proteins, of which α1-PI is a representative, as well as the proteolytic enzyme LE, which refl ects an increase in neutrophil degranulation activity, characterize "typical" infl ammation aimed at restoring disturbed homeostasis and are consistent with the results of our previous studies [20,21]. The increase in α1-PI activity may refl ect an acute-phase response caused by a previous COVID-19 infection, which ological infl ammatory process common to the pathogenesis of both infection-related and endogenous mental illness.…”

supporting

confidence: 89%

“…Thus, the overall results indicate that endogenous psychosis developing longer after coronavirus infection is associated with a "typical" infl ammatory reaction, with increases in the acute phase protein activities and neutrophil degranulation activity, which are associated with the development of depressive-delusional states in patients with predominance of the manifestations of positive affectivity (anxiety, melancholy) and the developed nature of delusional disorders. In terms of the levels of the infl ammatory mediators studied here, immune profi les did not differ from those previously identifi ed in other cohorts of patients with endogenous psychoses [20,21].…”

supporting

confidence: 43%

“…Our own studies have shown that LE activity refl ects the activity of the ongoing pathological process in the brain in endogenous psychoses, and this has repeatedly been confi rmed by the fi nding of correlations between the severity of patients' clinical condition and enzyme activity [20,21].…”

mentioning

confidence: 78%

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Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses

Zozulya

Сизов

Олейчик

et al. 2023

Neurosci Behav Physi

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Objectives. To carry out a clinical and immunological study of the potential impact of coronavirus infection on the course of endogenous psychoses. Materials and methods. A total of 33 female patients aged 16-48 years with depressive-delusional states (F20.01, F21, F31) developing after coronavirus infections took part; group 1 consisted of 15 people who developed depressive-delusional states 1-2 months after COVID-19; group 2 consisted of 18 people with similar psychoses developing at later time points (2-6 months). The severity of psychopathological symptoms was assessed using the PANSS and HDRS-21 scales. The activity of infl ammatory markers leukocyte elastase (LE) and α1-proteinase inhibitor (α1-PI) was determined in patients' blood. Absolute neutrophil and lymphocyte contents and their ratio (the neutrophil:lymphocyte index) were also evaluated. Standard values for indicators from healthy donors corresponding to patients in terms of age and sex were used as control values. Results. Endogenous psychosis developing at longer intervals after coronavirus infection (group 2) was found to be associated with "typical" infl ammatory reactions, with increases in the activity of acute-phase proteins (α1-PI: 43.0 (35.6-49.7) IU/ml, p = 0.001) and neutrophil degranulation activity (LE -254.8 (238.0-271.0) nmol/min•ml, p < 0.001), which was associated with the development of depressive-delusional states with dominance of manifestations of positive affectivity (anxiety, melancholy) and the extended nature of delusional disorders, which were mostly incongruent to affect. Conversely, development of endogenous psychosis during the fi rst two months after COVID-19 (group 1) was characterized by a spectrum of infl ammatory biomarkers with a decrease in neutrophil count ((2.6 ± 0.9)•10 9 /liter, p < 0.05) and low LE activity (196 (172-209.4) nmol/min•ml, p < 0.001). This immunological profi le was associated with predominance of manifestations of negative affectivity (apathy, asthenia, adynamia) in the structure of depressive-delusional states and the relatively undeveloped nature of delusional disorders, which were predominantly congruent to affect. Conclusions. The clinical and biological correlates found here presumptively indicate that experience of COVID-19 infection has a modulatory effect on neuroinfl ammation and the structure of endogenous psychosis.

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supporting

confidence: 89%

supporting

confidence: 43%

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Clinical-Immunological Correlates in Post-COVID-19 Endogenous Psychoses

Zozulya

Сизов

Олейчик

et al. 2023

Neurosci Behav Physi

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“…A greater severity of negative symptoms and cognitive impairments was revealed with a decrease in the level of regulatory T cells (a decrease in their level contributes to the development of autoimmune reactions in schizophrenia) [88][89][90]. This contradicts some of the work of other years, according to which pronounced psychotic symptoms are "consistent" with a significant distortion of immune indicators [91][92][93].…”

Section: Neurodegenerative Theorymentioning

confidence: 99%

“…A systematic interdisciplinary approach seems to be required to be able to draw some solid conclusions regarding the etiology of schizophrenia [4,10,16,17,31,39,44,47,66,91,100].…”

Section: The Disease Does Not Manifest Itself In Clinicalmentioning

confidence: 99%

Schizophrenia: a Narrative Review of Etiological and Diagnostic Issues

Осколкова

2022

Consortium Psychiatricum

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BACKGROUND: Despite the fact that schizophrenia has already been described historically and researched for a long time, this disorder remains unclear and controversial in many respects, including its etiology, pathogenesis, classification, diagnosis, and therapy. METHODS: Literature from the selected sources (elibrary.ru, Russian Science Citation Index and the Russian branch of the Cochrane Library) were searched and analyzed using the diachronic method. Priority was given to reviews, guidelines, and original research on schizophrenia written during the past 10 years. RESULTS: Historically, scientists have described schizophrenia as a single disorder, a group of disorders, or even as a combination of certain syndromes. The polymorphic symptoms and the most typical dynamics of various forms of schizophrenia have been systematized, but neither in Russia nor in other countries have the etiology and pathogenesis been proven. The reasons for the under- and overdiagnosis of schizophrenia cannot cover all possible objective and subjective difficulties arising in the diagnostic process. CONCLUSION: The existing literature shows that the problem of schizophrenia may not be regarded as settled for a long time. This largely depends on the position of society, the development of biological sciences, and the pathomorphosis of the disorder itself. Many aspects of schizophrenia can become clearer and less controversial with systematic studies based on previous data, as well as data obtained using new research methods.

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