Specific features of drug encapsulation in liposomes (A review)

Abstract

Liposomes are hollow particles, the internal space of which is bounded by a lipid membrane. Liposomes are promising drug delivery systems for organs and tissues because of their colloidal properties, controlled size, surface characteristics, membrane action, and biocompatibility. Liposomal drugs have found wide use in the diagnosis and chemotherapy of cancer, vaccinology, ophthalmology, pulmonology, and the treatment of other pathologies. This review describes the methods of encapsulation of biologically active compounds with various physicochemical properties in liposomes, which is very important for the production of liposomal drugs.

High‐Throughput Continuous Flow Production of Nanoscale Liposomes by Microfluidic Vertical Flow Focusing

“…Due to their ability to encapsulate hydrophilic drugs within their aqueous cores and lipophilic compounds within their lipid bilayers while supporting tailored surface chemistries for targeted delivery and extended blood circulation time, liposomes can serve as versatile and multifunctional nanoparticles for numerous drug delivery applications . Liposomal drugs have been shown to increase therapeutic index while minimizing toxicity compared to the use of free drugs, with significant applications in the treatment of cancer and a variety of other pathologies . Liposomes also offer notable advantages for vaccine development, biosensors, and diagnostic imaging …”

Selection and optimization of nano-formulation of P-glycoprotein inhibitor for reversal of doxorubicin resistance in COLO205 cells

“…The liposomes were loaded with DOX by ammonium sulfate gradient that is considered to be most efficient, and in our conditions, more than 95% encapsulation were obtained (data not shown). [25,26] The liposomes were found to have a Z-average size of 126.7 nm with a narrow size distribution yielding a poly dispersity index of 0.068 (Figure S5b). The DOX loaded liposomes had a zeta potential of À15.6 AE 3.05 mV.…”

Self-Assembling Amphiphilic Hyperbranched Polyglycerol-Polystyrene Copolymers for Encapsulation

“…[ 2,25,26 ] This work invites the question of whether hyperbranched polymers exhibit the same trend. Using these f-values as a guide for the generation of vesicles, a variety of amphiphilic hyperbranched diblock polymers (PS 2K HPG 3K , PS 2K HPG 8K , PS 6.5K HPG 3K , PS 6 were synthesized to test the structural composition ( Table 1 ).…”

“…[ 5 ] Adjusting the structural composition of the constituent lipids, dendrimers, and polymers allows the mechanical properties of the resulting vesicle to be tuned, including its membrane stability, bilayer thickness, leakage rate, and encapsulation effi ciency. [ 6 ] For example, liposomes are notoriously leaky as a result of the fl uidity of the phospholipid bilayer. In contrast, dendrimersomes are much less leaky in part because their branched structures are denser and may further entwine.…”