Specific electromagnetic radiation in the wireless signal range increases wakefulness in mice

Liu, Lingyu; Deng, Hang; Tang, Xiaping; Lu, Yingxian; Zhou, Jiayao; Wang, Xiaofei; Zhao, Yanyu; Huang, Bing; Shi, Yigong

doi:10.1073/pnas.2105838118

Cited by 61 publications

(45 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lateef and colleagues also found a statistically significant positive correlation between Internet addiction and insomnia among clinical medical students in Africa ( 52 ). We confirmed the H-01 and the role of melatonin could account for the relationship between smartphone overuse and sleep deprivation, which has been confirmed by animal and human studies ( 29 ). Melatonin is one of the hormones secreted by the pineal gland, which helps sleep and regulates the circadian clock ( 53 ).…”

Section: Discussionsupporting

confidence: 85%

“…In addition to the above psychological models, clinical mechanisms are beneficial to support our theoretical model regarding the relationship of PSU, sleep quality, and daytime fatigue. Blue light and electromagnetic radiation emitted by smartphones directly cause harm to users' eyesight, neck, and spine ( 14 , 29 ). Suppression of melatonin secretion caused by light stimulation at night is also a commonly recognized physiological pathway that results in sleep deprivation ( 30 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship of Problematic Smartphone Use, Sleep Quality, and Daytime Fatigue Among Quarantined Medical Students During the COVID-19 Pandemic

et al. 2021

View full text Add to dashboard Cite

Background: The COVID-19 pandemic brought about great transformation to medical education mode. Although mobile communication devices played a crucial role in online learning among quarantined university students, the potential smartphone addition problems, negative health behaviors, and psychological symptoms need considerable attention. This study examined the relationship of problematic smartphone use (PSU), sleep quality, and daytime fatigue among medical students.Methods: A web-based survey was conducted in six polyclinic hospitals in Beijing between February and May 2020. 1016 participants (26.01 ± 2.46 years, 65.16% female) completed self-report measurements including Short Version Smartphone Addiction Scale (SAS-SV), Athens Insomnia Scale (AIS), and Subjective Fatigue Scale (FS). Spearman correlation coefficients and multiple regression models were used to analyze the association among PSU, sleep quality, and daytime fatigue. We used structural equation modeling to test the mediating effect of sleep quality between PSU and daytime fatigue.Results: 49.70% of the participants had PSU. Significant positive correlations were found among SAS-SV, AIS, and FS scores (r = 0.35–0.61, PS < 0.001). Subjects with PSU were more likely to report sleep disturbance (β = 1.07, P < 0.001, OR = 2.91, 95%CI = 2.17–3.91), physical fatigue (β = 1.16, P < 0.001, OR = 3.18, 95%CI = 2.45–4.15), and mental fatigue (β = 0.88, P < 0.001, OR = 2.42, 95%CI = 1.86–3.14). The indirect effect of PSU on physical fatigue and mental fatigue mediated by sleep quality accounted for 50.03 and 45.43% of the total effect, respectively.Conclusions: PSU was significantly associated with sleep disturbance and fatigue among medical students during the COVID-19 pandemic. Sleep quality mediated the relationship between PSU and daytime fatigue. Our results provide valuable information for maintaining medical students' health status and constructing online education structures.

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Relationship of Problematic Smartphone Use, Sleep Quality, and Daytime Fatigue Among Quarantined Medical Students During the COVID-19 Pandemic

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The impacts on zebrafish anxiety-related behavior are consistent with previous studies in rodent models that showed ongoing GHz or sub-GHz RFRs could alter behavior and sleep patterns. 6 , 15 While there was no direct correspondence between an abnormal larval behavior and an abnormal adult behavior, it is likely that the adult effects were manifestations of RFR impacts on development. Studies with embryonic neural stem cells have shown that RFR exposures can inhibit neural outgrowth that can potentially impact nervous system function in the long term.…”

Section: Resultsmentioning

confidence: 99%

Transcriptomic and Long-Term Behavioral Deficits Associated with Developmental 3.5 GHz Radiofrequency Radiation Exposures in Zebrafish

Dasgupta

Leong

Simonich

et al. 2022

Environ. Sci. Technol. Lett.

View full text Add to dashboard Cite

The rapid deployment of the fifth-generation (5G) spectrum by the telecommunication industry is intended to promote better connectivity and data integration among various industries. However, concerns among the public about the safety and health effects of radiofrequency radiations (RFRs) emitted from the newer-generation cell phone frequencies remain, partly due to the lack of robust scientific data. Previously, we used developmental zebrafish to model the bioactivity of 3.5 GHz RFR, a frequency used by 5G-enabled cell phones, in a novel RFR exposure chamber. With RFR exposures from 6 h post-fertilization (hpf) to 48 hpf, we observed that, despite no teratogenic effects, embryos showed subtle hypoactivity in a startle response behavior assay, suggesting abnormal sensorimotor behavior. This study builds upon the previous one by investigating the transcriptomic basis of RFR-associated behavior effects and their persistence into adulthood. Using mRNA sequencing, we found a modest transcriptomic disruption at 48 hpf, with 28 differentially expressed genes. KEGG pathway analysis showed that biochemical pathways related to metabolism were significantly perturbed. Embryos were grown to adulthood, and then a battery of behavioral assays suggested subtle but significant abnormal responses in RFR-exposed fish across the different assays evaluated that suggest potential long-term behavioral effects. Overall, our study suggests the impacts of RFRs on the developing brain, behavior, and the metabolome should be further explored.

show abstract

“…Therefore, physical therapies have been used to treat chronic insomnia [ 4 , 5 ]. Electric, magnetic, and electromagnetic fields have been applied to modulate sleep in a series of clinical and experimental studies [ 6 , 7 , 8 ]. Most of these treatment approaches were non-invasive and less stimulant.…”

Section: Introductionmentioning

confidence: 99%

Modulation of Sleep Architecture by Whole-Body Static Magnetic Exposure: A Study Based on EEG-Based Automatic Sleep Staging

Yang

Jiang

Ding

et al. 2022

IJERPH

View full text Add to dashboard Cite

A steady increase in sleep problems has been observed along with the development of society. Overnight exposure to a static magnetic field has been found to improve sleep quality; however, such studies were mainly based on subjective evaluation. Thus, the presented data cannot be used to infer sleep architecture in detail. In this study, the subjects slept on a magneto-static mattress for four nights, and self-reported scales and electroencephalogram (EEG) were used to determine the effect of static magnetic field exposure (SMFE) on sleep. Machine learning operators, i.e., decision tree and supporting vector machine, were trained and optimized with the open access sleep EEG dataset to automatically discriminate the individual sleep stages, determined experimentally. SMEF was found to decrease light sleep duration (N2%) by 3.51%, and sleep onset latency (SOL) by 15.83%, while it increased deep sleep duration (N3%) by 8.43%, compared with the sham SMFE group. Further, the overall sleep efficiency (SE) was also enhanced by SMFE. It is the first study, to the best of our knowledge, where the change in sleep architecture was explored by SMFE. Our findings will be useful in developing a non-invasive sleep-facilitating instrument.

show abstract

Specific electromagnetic radiation in the wireless signal range increases wakefulness in mice

Cited by 61 publications

References 41 publications

Relationship of Problematic Smartphone Use, Sleep Quality, and Daytime Fatigue Among Quarantined Medical Students During the COVID-19 Pandemic

Relationship of Problematic Smartphone Use, Sleep Quality, and Daytime Fatigue Among Quarantined Medical Students During the COVID-19 Pandemic

Transcriptomic and Long-Term Behavioral Deficits Associated with Developmental 3.5 GHz Radiofrequency Radiation Exposures in Zebrafish

Modulation of Sleep Architecture by Whole-Body Static Magnetic Exposure: A Study Based on EEG-Based Automatic Sleep Staging

Contact Info

Product

Resources

About