Specific diagnosis of hepatoma using 99mTc-HIDA and other radionuclides

Lee, Victor W.; Shapiro, Jerome H.

doi:10.1007/bf00253764

Cited by 13 publications

(5 citation statements)

References 16 publications

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“…The observations of uptake of hepatobiliary radiopharmaceuticals by hepatoma (Belfer et al 1979), hepatocellular carcinoma (Shoop 1969;Lee and Shapiro 1983) and hepatoblastoma (De Kraker etal. 1989) led De to administer a therapeutic dose of 1.85 GBq (50 mCi) 13~I Rose Bengal to a 7-month-old child with hepatoblastoma, which was progressive after radiotherapy and chemotherapy and which demonstrated considerable uptake and retention of ~3aI Rose Bengal (tumour uptake 28.7% of the dose of 24 h).…”

Section: /Rose Bengalmentioning

confidence: 99%

Radionuclide therapy revisited

Hoefnagel

1991

Eur J Nucl Med

123

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Apart from its use in endocrinology and rheumatology, therapeutic nuclear medicine is developing rapidly as an additional treatment modality in oncology. Many different specific tumour-seeking radiopharmaceuticals are being applied both for diagnostic scintigraphy and treatment, using multiple routes and mechanisms to target radionuclides at tumours. After a brief introduction of some basic principles of radionuclide targeting, the therapeutic radiopharmaceuticals available are reviewed according to the accumulation site in relation to the cell nucleus; the results of their current clinical use for therapy are also reviewed. The response observed to a number of these applications, the non-invasiveness of the procedure and the relative lack of toxicity and late effects in comparison with chemotherapy and external beam radiotherapy make radionuclide therapy an attractive and realistic alternative in the management of malignant disease, as well as in the treatment of a few benign disorders.

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Section: /Rose Bengalmentioning

confidence: 99%

Radionuclide therapy revisited

Hoefnagel

1991

Eur J Nucl Med

123

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“…In 11 of these cases, both a 99J'c ffi sulphur colloid and a gallium scan were performed, and there was a relative increase in gallium uptake in the area with decreased sulphur colloid uptake. Some authors have reported uptake in hepatoma of agents processed by hepatocytes (12,16). However, SAVITCH et coll.…”

Section: Resultsmentioning

confidence: 98%

Radionuclide Angiography and Scintigraphy in Hepatocellular Carcinoma

Friman¹,

Nilsson²,

Udén³

1985

Acta Radiologica. Diagnosis

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Among 1 257 patients subjected to liver-spleen (RES) scintigraphy and radionuclide angiography (RNA), there were 13 cases of histologically confirmed hepatocellular carcinoma (1%). All 13 patients had scintigraphic findings indicating cirrhosis. Histologically, cirrhosis was present in only 9 out of 11 cases in which liver parenchyma was available for examination. One patient had hemochromatosis without evidence of cirrhosis. In 11 cases, the tumor was clearly demonstrated as a defect in the static scintigram. However, in 2 cases with cirrhosis and poorly differentiated hepatocellular carcinoma, the tumor nodules were hardly discernible. In RNA, the tumor displayed high activity in the arterial phase and decreasing activity during the portal phase, ending up as a defect. At RNA, the lesion was clearly outlined in 12 cases, including the 2 patients in whom the scintigraphic findings were inconclusive; in one case with severe cirrhosis and a well differentiated hepatocellular carcinoma, the tumor was barely detectable. We conclude that a combination of RNA and scintigraphy is a valuable screening which usually provides a correct diagnosis in hepatocellular carcinoma.

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“…1 $' 19 However, it has not yet been clarified whether the uptake of ahepatobiliary imaging agent by the primary tumor of HCC is related to the bile formation in the tumor tissues or not. Of the 64 patients with HCC examined histologically, only 7 showed morphological evidence of bile formation in the tumor tissues of the liver.…”

Section: Discussionmentioning

confidence: 99%

Analysis of factors affecting uptake of Tc-99m Sn-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma

et al. 1994

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We performed Tc-99m PMT imaging in 176 patients with HCC and evaluated factors affecting 99mTc-PMT uptake by HCC with a logistic model. The probability of HCC showing increase in uptake of the radioisotope was 104.6 times higher in patients with the Ed I type than in those with the Ed III type and 12.1 times higher in patients with a tumor diameter of 5.0-7.9 cm than in those with a tumor diameter of 2.0-5.0 cm. Among the other variables, the serum AFP level and sex were suggested to have effects similar to those of the tumor size on Tc-99m PMT uptake by HCC. The grade of morphological differentiation of the tumor was therefore most markedly related to Tc-99m PMT uptake.

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Specific diagnosis of hepatoma using 99mTc-HIDA and other radionuclides

Cited by 13 publications

References 16 publications

Radionuclide therapy revisited

Radionuclide therapy revisited

Radionuclide Angiography and Scintigraphy in Hepatocellular Carcinoma

Analysis of factors affecting uptake of Tc-99m Sn-N-pyridoxyl-5-methyltryptophan by hepatocellular carcinoma

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