Specific determination of intact cisplatin and monohydrated cisplatin in human plasma and culture medium ultrafiltrates using HPLC on-line with inductively coupled plasma mass spectrometry

Bell, Deanna; Liu, JJ; Tingle, Malcolm D.; McKeage, Mark J.

doi:10.1016/j.jchromb.2006.03.063

Cited by 37 publications

(31 citation statements)

References 16 publications

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“…A minor fraction of low molecular weight platinum species was identified by two complementary LC ICP MS techniques after 24 h incubation of proliferating living cells (mesothelioma cell model P31) with preclinically relevant cisplatin concentrations [153]. The determination of intact cisplatin and its monohydrated complex in human plasma [154] and of metabolites of drug ZD 0472 in urine [155] and animal plasma ultrafiltrate [156] are examples of the application of HPLC ICP MS and HPLC MS/MS techniques. Substantial improvement in DLs of cisplatin and its hydrated complex determined by LC ICP MS was achieved by using dimethylformamide as modifier of the mobile phase [157].…”

Section: Determination Of Platinum In Clinical Samplesmentioning

confidence: 99%

Quantification of Noble Metals in Biological and Environmental Samples

Balcerzak

2016

Handbook of Trace Analysis

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Section: Determination Of Platinum In Clinical Samplesmentioning

confidence: 99%

Quantification of Noble Metals in Biological and Environmental Samples

Balcerzak

2016

Handbook of Trace Analysis

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“…Speciation analysis of these intermediates is gaining interest. Methods applying ICP-MS have been developed for the speciation and quantification of the parent drugs and metabolites of cisplatin (Zhao et al, 1993;Bell et al, 2006), BBR3463 (Vacchina et al, 2003), satraplatin (Cairns, Ebdon, & Hill, 1994Galettis et al, 1999;Carr, Tingle, & McKeage, 2002), oxaliplatin (Allain et al, 2000), and ZD0473 (Smith et al, 2003) in matrices such as whole blood, red blood cells, plasma, pUF, pP, and urine. A summary of the assays is presented in Table 4.…”

Section: Speciation Of Metal-based Compounds and Metabolitesmentioning

confidence: 99%

“…The organic content of the mobile phases was purposely kept low (3% n-propanol for the hydrolysis products and 10% methanol for the thiol compounds) to ensure the stability of the plasma. SDS in a 3% methanol containing mobile phase was also used in another application for the speciation of cisplatin and monohydrated cisplatin (Bell et al, 2006). Although the mobile phase changed the overall appearance of the argon plasma, the Pt counts were only slightly suppressed and thus adequate results were achieved.…”

Section: Reversed Phase Ion-pairing Chromatography (Rpipc)mentioning

confidence: 99%

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

Brouwers

Tibben

Rosing

et al. 2008

Mass Spectrometry Reviews

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Metal-based anticancer agents are frequently used in the treatment of a wide variety of cancer types. The monitoring of these anticancer agents in biological samples is important to understand their pharmacokinetics, pharmacodynamics, and metabolism. In addition, determination of metals originating from anticancer agents is relevant to assess occupational exposure of health care personnel working with these drugs. The high sensitivity of inductively coupled plasma mass spectrometry (ICP-MS) has resulted in an increased popularity of this technique for the analysis of metal-based anticancer drugs. In addition to the quantitative analysis of the metal of interest in a sample, ICP-MS can be used as an ultrasensitive metal selective detector in combination with speciation techniques such as liquid chromatography. In the current review we provide a systematic survey of publications describing the analysis of platinum-and ruthenium-containing anticancer agents using ICP-MS, focused on the determination of total metal concentrations and on the speciation of metal compounds in biological fluids, DNA-and protein-adducts, and environmental samples. We conclude that ICP-MS is a powerful tool for the quantitative analysis of metal-based anticancer agents from multiple sample sources.

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“…Selective methods such as high-performance liquid chromatography (HPLC) have been applied for the determination method of cisplatin in biological systems [6], while inductively-coupled plasma can also be used for this end [7]. The use of different methods is justified by the nature of this drug, because it can be hydrolyzed to give diverse hydroxo-bridged complexes [8].…”

Section: Introductionmentioning

confidence: 99%

Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

González‐Torres¹,

Torres²,

Torres³

et al. 2017

ChChT

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Abstract.1 Cis-diaminedichloroplatinum(II), also known as cisplatin, has been quantified by use of inductivelycoupled plasma. We measured cisplatin indirectly by determining the platinum concentration in the samples. We focus on the determination of Pt from cisplatin in water. We demonstrate that the total concentration of the drug can be quantified through the content of platinum with acceptable linearity, precision, repeatability, accuracy, limit of detection and limit of quantification. Our method is applicable among others for monitoring quality of control samples for cisplatin regulatory submissions and for determination of the cisplatin release profiles in biomarker implants in vitro.

show abstract

Specific determination of intact cisplatin and monohydrated cisplatin in human plasma and culture medium ultrafiltrates using HPLC on-line with inductively coupled plasma mass spectrometry

Cited by 37 publications

References 16 publications

Quantification of Noble Metals in Biological and Environmental Samples

Quantification of Noble Metals in Biological and Environmental Samples

The application of inductively coupled plasma mass spectrometry in clinical pharmacological oncology research

Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

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