Specific detection of hypochlorite based on the size-selective effect of luminophore integrated MOF-801 synthesized by a one-pot strategy

Li, Yongsheng; Zhao, Liwei; Hu, Shuanggang; Liang, Ajuan; Zhuang, Qixin; Tao, Guorong; Gu, Jinlou

doi:10.1039/c8dt04692a

Cited by 30 publications

(16 citation statements)

References 64 publications

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“…A low limit of detection (LOD) of ClO – was obtained to be 37 nM, which owned a superior performance to most fluorescent probes for the ClO – detection (Table S3). ,,− The concentration of ClO – could be detected immediately after adding Eu-BDC-NH 2 /DPA and stirring for 5 s, so the detection of ClO – is achieved within 20 s.…”

Section: Resultsmentioning

confidence: 99%

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

2021

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Sensitivity, selectivity, visible detection, and rapid response are the main concerns for an analytical method. Herein, we reported a metal–organic framework (MOF)-based ratiometric fluorescence detection strategy for hypochlorous acid (HClO). The MOF was prepared with dual ligands, 2-aminoterephthalic acid (BDC-NH2) and dipicolinic acid (DPA) and Eu3+ ions as a metal node, denoted as Eu-BDC-NH2/DPA. The dual-ligand strategy realized the dual emission for ratiometric sensing and visual detection, adjusted the size and morphology of MOFs to obtain a good dispersion for a rapid response, and provided an amino group for the special recognition of HClO. Thus, the MOF exhibited a dual emission derived from BDC–NH2 and Eu3+ ions at 433 and 621 nm, respectively, under a single excitation at 270 nm. A hydrogen bond forms between an −NH2 group and HClO to weaken the blue fluorescence at 433 nm, while the antenna effect emission from Eu3+ ions kept stable, so ratiometric sensing was realized with an easy-to-differentiate color change for visible detection. The ratiometric sensing showed a self-calibration effect and reduced the background. Thus, the high sensitivity, visual detection, low detection limit (37 nM), and short response time (within 20 s) for the detection of HClO were realized with the MOF as a probe. The analysis of real samples demonstrated the practical application of the MOF for HClO. The introduction of mixed ligands is an effective strategy to regulate the emission behaviors of MOFs for the improved analytical performance.

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Section: Resultsmentioning

confidence: 99%

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

2021

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“…18 However, fluorescence-based methods deliver the most promising results in several organisms with extraordinary sensitivity and selectivity. So far, many fluorescent sensors have been reported for Pb 2+ and ClO − recognition, including organic fluorophores, rare earth metal coordination complexes, 19 metal−organic frameworks, 20 and nanoclusters. 21 However, these materials require a vigorous, time-consuming synthesis technique and cannot effectively penetrate into the cell.…”

Section: •−mentioning

confidence: 99%

Hit Multiple Targets with One Arrow: Pb²⁺ and ClO^– Detection by Edge Functionalized Graphene Quantum Dots and Their Applications in Living Cells

Nandi

Gaurav

Sarkar

et al. 2021

ACS Appl. Bio Mater.

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Recently, multimodal detection of analytes through a single nanoprobe has become an eminent approach for researchers. Herein a fluorescent nanoprobe, functionalized-GQD (F-GQD), has been designed through edge functionalization of graphene quantum dots (GQDs) by 2,6diaminopyridine molecules. The fluorescence of F-GQD is quite sensitive to medium pH, making it a suitable pH sensor within the pH range 2−6. Interestingly, F-GQD shows dual sensing of Pb 2+ and ClO − by entirely different pathways; Pb 2+ exhibits fluorescence turn-on performance while ClO − triggers turn-off fluorescence quenching. The fluorescence enhancement may originate from the Pb 2+ -induced aggregation of the nanodots. The limit of detection (LOD) was also impressive, 1.2 μM and 12.6 nM for Pb 2+ and ClO − , respectively. The detailed mechanistic investigations reveal that both dynamic and static quenching effects operate together in the F-GQD-ClO − system. The dynamic quenching was attributed to the energy migration from F-GQD to ClO − through hydrogen bonding interaction (static quenching) between the amine group at the F-GQD surface and ClO − . The F-GQD nanodot reveals excellent sensitivity toward the detection of ClO − in real samples. Moreover, the F-GQDs also serve as multicolor fluorescent probes for cell imaging; the probe can easily penetrate the cell membrane and successfully detect intracellular ClO − .

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“…Gu et al presented a novel luminophore integrated MOF system, AF@MOF-801, for specific detection of HClO [119]. The composite AF@MOF-801 can be readily prepared via a one-step process by using 5-aminofluorescein (AF) as a co-reactant in the synthesis of MOF-801 (Figure 15a).…”

Section: Mof-based Chemodosimeters For Other Redox-active Biomolecmentioning

confidence: 99%

“…( d ) The confocal laser scanning microscopy images of SMMC-7721 cells incubated with AF@MOF-801 and with various concentrations of ClO − . Reproduced with permission from [119]. Copyright the Royal Society of Chemistry, 2019.…”

Section: Figurementioning

confidence: 99%

Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters

et al. 2019

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Metal–organic frameworks (MOFs), as a class of crystalline hybrid architectures, consist of metal ions and organic ligands and have displayed great potential in luminescent sensing applications due to their tunable structures and unique photophysical properties. Until now, many studies have been reported on the development of MOF-based luminescent sensors, which can be classified into two major categories: MOF chemosensors based on reversible host–guest interactions and MOF chemodosimeters based on the irreversible reactions between targets with a probe. In this review, we summarize the recently developed luminescent MOF-based chemodosimeters for various analytes, including H2S, HClO, biothiols, fluoride ions, redox-active biomolecules, Hg2+, and CN−. In addition, some remaining challenges and future perspectives in this area are also discussed.

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Specific detection of hypochlorite based on the size-selective effect of luminophore integrated MOF-801 synthesized by a one-pot strategy

Abstract: Intracellular hypochlorite could be rapidly and specifically detected with novel luminescent AF@MOF-801 nanoparticles based on a size-selective effect.

Cited by 30 publications

References 64 publications

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

Hit Multiple Targets with One Arrow: Pb²⁺ and ClO^– Detection by Edge Functionalized Graphene Quantum Dots and Their Applications in Living Cells

Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters

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Specific detection of hypochlorite based on the size-selective effect of luminophore integrated MOF-801 synthesized by a one-pot strategy

Abstract: Intracellular hypochlorite could be rapidly and specifically detected with novel luminescent AF@MOF-801 nanoparticles based on a size-selective effect.

Cited by 30 publications

References 64 publications

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

Dual-Ligand Lanthanide Metal–Organic Framework for Sensitive Ratiometric Fluorescence Detection of Hypochlorous Acid

Hit Multiple Targets with One Arrow: Pb2+ and ClO– Detection by Edge Functionalized Graphene Quantum Dots and Their Applications in Living Cells

Recent Progress in Metal–Organic Framework (MOF) Based Luminescent Chemodosimeters

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Hit Multiple Targets with One Arrow: Pb²⁺ and ClO^– Detection by Edge Functionalized Graphene Quantum Dots and Their Applications in Living Cells