Specific Dermoscopy Patterns and Amplifications of the Cyclin D1 Gene to Define Histopathologically Unrecognizable Early Lesions of Acral Melanoma In Situ

Yamaura, Maki; Takata, Minoru; Miyazaki, Atsushi; Saida, Toshiaki

doi:10.1001/archderm.141.11.1413

Cited by 49 publications

(46 citation statements)

References 23 publications

(28 reference statements)

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“…2B). Histopathology of some of these very early lesions showed only a slight increase of non-atypical melanocytes in the basal cell layer of the epidermis [43]. These observations suggest that amplification of the CCND1 gene might be one of the initiating events of melanoma development in the glabrous skin.…”

Section: Gene Amplifications Define Early Lesions Of Acral Melanomamentioning

confidence: 76%

Genetic alterations in melanocytic tumors

Takata

Saida

2006

Journal of Dermatological Science

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Section: Gene Amplifications Define Early Lesions Of Acral Melanomamentioning

confidence: 76%

Genetic alterations in melanocytic tumors

Takata

Saida

2006

Journal of Dermatological Science

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“…[30][31][32][35][36][37]66 They typically reveal pigmented parallel lines located within the furrows of skin markings (parallel furrow pattern), whereas melanoma shows pigmentation on the ridges (parallel ridge pattern). [81][82][83] The differentiation between parallel furrow and parallel ridge pattern may be at times difficult (particularly in the center of the lesion); for these cases, the furrow ink test represents a practical aid for correct diagnosis. 84 Although the dermoscopic pattern of subungual, facial, and genital nevi have been described in various case series, they are much less well defined, and their assessment and interpretation often requires a high level of expertise.…”

Section: Commentmentioning

confidence: 99%

Using Dermoscopic Criteria and Patient-Related Factors for the Management of Pigmented Melanocytic Nevi

Zalaudek

Docimo

Argenziano³

2009

Arch Dermatol

100

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Objective: To review recent dermoscopy studies that provide new insights into the evolution of nevi and their patterns of pigmentation as they contribute to the diagnosis of nevi and the management of pigmented melanocytic nevi. Data Sources: Data for this article were identified by searching the English and German literature by Medline and Journals@Ovid search for the period 1950 to January 2009. Study Selection: The following relevant terms were used: dermoscopy, dermatoscopy, epiluminescence microscopy (ELM), surface microscopy, digital dermoscopy, digital dermatoscopy, digital epiluminescence microscopy, digital surface microscopy, melanocytic skin lesion, nevi, and pigmented skin lesions. There were no exclusion criteria. Data Synthesis: The dermoscopic diagnosis of nevi relies on the following 4 criteria (each of which is characterized by 4 variables): (1) color (black, brown, gray, and blue); (2) pattern (globular, reticular, starburst, and homogeneous blue pattern); (3) pigment distribution (multifocal, central, eccentric, and uniform); and (4) special sites (face, acral areas, nail, and mucosa). In addition, the following 6 factors related to the patient might influence the pattern of pigmentation of the individual nevi: age, skin type, history of melanoma, UV exposure, pregnancy, and growth dynamics. Conclusions: The 4×4×6 “rule” may help clinicians remember the basic dermoscopic criteria of nevi and the patient-related factors influencing their patterns. Dermoscopy is a useful technique for diagnosing melanocytic nevi, but the clinician should take additional factors into consideration to optimize the management of cases of pigmented lesions.

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“…2). 15 These observations suggest that amplification of the cyclin D1 gene might be an initiating event of melanoma development in glabrous skin. Bastian 16 termed these genetically aberrant cells with normal morphology "field cells" and suggested that there is a latent progression phase that precedes the stage of melanocyte proliferation in the epidermis.…”

Section: Molecular Pathways To Early Melanoma Developmentmentioning

confidence: 92%

Early cancers of the skin: clinical, histopathological, and molecular characteristics

Takata

Saida

2005

Int J Clin Oncol

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Because skin lesions are visible and easily accessible, skin cancers provide us with an excellent in vivo model to study the development of cancers. Cutaneous malignant melanoma and squamous cell carcinoma (SCC) both arise from the epidermis and have an initial progression stage in which proliferation of the neoplastic cells is confined to the epidermis. This stage is called melanoma in situ or SCC in situ. Molecular analyses of melanoma in situ and of solar keratosis, a prototype of early SCC in situ, show that loss of p16(INK4a)/p14(ARF) and dysfunction of p53 play a critical role, respectively. Furthermore, there seems to be potential precursor cells to these in situ lesions, which are not discernible with conventional hematoxylin and eosin-stained sections. The precursor cells have minimal but critical genetic alterations, such as cyclin D1 amplification and p53 mutation, and can be identified using fluorescent in situ hybridization and immunostaining with p53 antibodies, respectively. These precursor cells may be defective in repair response to DNA damage, and would have proliferative or survival advantages over their normal neighboring counterparts in the presence of growth factor stimulation or genotoxic events, such as ultraviolet irradiation. Such precursor clones may be induced at a rather young age, and their number and size increase with accumulating carcinogenic stimuli. If these lesions acquire additional mutations, they could progress to clinically visible lesions of in situ carcinoma. Precise molecular analyses of early stages of skin cancers may have a strong impact on our understanding of in vivo development of cancers in other human organs.

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Specific Dermoscopy Patterns and Amplifications of the Cyclin D1 Gene to Define Histopathologically Unrecognizable Early Lesions of Acral Melanoma In Situ

Cited by 49 publications

References 23 publications

Genetic alterations in melanocytic tumors

Genetic alterations in melanocytic tumors

Using Dermoscopic Criteria and Patient-Related Factors for the Management of Pigmented Melanocytic Nevi

Early cancers of the skin: clinical, histopathological, and molecular characteristics

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