Specific chiral recognition of amino acid enantiomers promoted by an enzymatic bioreactor in MOFs

Yang, Jian; Jiang, Yao; Tao, Guorong; Gu, Jinlou

doi:10.1039/d1tc04106a

Cited by 7 publications

(9 citation statements)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To demonstrate the generality of this enzyme-assisted sensing strategy, we further designed an enantioselective fluorescent probe to recognize and quantify chiral amino acids. 48 The system was composed of three components: A Ce-based HPMOF served as the platform for the integration of functional units. Natural L-amino acid oxidase immobilized in mesopores as an enantioselective recognition unit.…”

Section: Hpmofs With Designable Componentsmentioning

confidence: 99%

See 1 more Smart Citation

Hierarchically Porous MOFs Synthesized by Soft-Template Strategies

Yang

2022

Acc. Chem. Res.

Self Cite

View full text Add to dashboard Cite

Metrics & MoreArticle Recommendations CONSPECTUS:The past few decades have been witnessing the rapid research boom of metal−organic frameworks (MOFs), which are assembled from metal nodes and multitopic organic linkers. In virtue of their modular assembly mode, they can be tailored according to desired functions to satisfy numerous potential applications. However, most initially reported MOFs were restricted to the microporous regime, limiting their practical applications with bulk molecules involved. Therefore, the research attention was immediately directed toward enlarging the intrinsic pore size of frameworks by extending the secondary building units or organic ligands. Unfortunately, the synthesis of more extended ligands is frequently tedious, and the most resultant MOFs are not sufficiently stable, restricting their popularization. The soft-template strategy is recognized as a promising avenue to produce hierarchically porous MOFs (HPMOFs), although early attempts generally failed due to the incompatibility between the surfactant self-assembly and guided crystallization process of MOF precursors in the organic phase. Therefore, developing a rational soft-template strategy to achieve the precise control of morphology and porosity of HPMOFs is of great significance.In this Account, we present our recent progress on the development and applications of HPMOFs prepared by soft-template strategies. We highlight the key issues upon using the soft-template strategy to synthesize HPMOFs. To enhance the interaction between the template and MOF precursor, a long-chain monocarboxylic acid strategy is introduced to synthesize HPMOFs with irregular mesopores in the organic phase. Then, to improve the order of mesopores, an aqueous-phase synthesis method using amphoteric surfactants as templates is developed to prepare ordered HPMOFs. To further enlarge the pore size and make the synthesis conditions of MOFs compatible with the self-assembly of surfactants, a salting-in species-induced self-assembly strategy is proposed and coupled with the structure-directing properties of copolymer templates to synthesize a series of HPMOFs with large mesopores and even macropores. This salting-in ion-mediated self-assembly (SIMS) strategy paves the way to modify the pore size, pore structure, morphology, and chemical composition of HPMOFs. The separated but intimately interconnected hierarchical pores in the resultant HPMOFs can not only realize rapid mass transport but also isolate different-size guest molecules so that they are competent for a broad range of applications including protein digestion, cascade catalysis, enzyme-assisted substrate sensing, and DNA cleavage. Finally, the limitations, challenges, and future developments of this rapidly evolving field are described. This Account with a highlight to the soft-template strategies not only provides interesting insights to understand the assembly process between templates and MOFs but also inspires an optimization of the properties of HPMOFs from diverse aspects for desired app...

show abstract

Section: Hpmofs With Designable Componentsmentioning

confidence: 99%

“…(b) Schematic illustration for the enantioselective fluorescent probe for the chiral recognition and quantification of amino acid. Reproduced with permission from ref . Copyright 2021 The Royal Society of Chemistry.…”

Section: Function Customization and Corresponding Applicationsmentioning

confidence: 99%

Hierarchically Porous MOFs Synthesized by Soft-Template Strategies

Yang

2022

Acc. Chem. Res.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Luminescent metal–organic frameworks (LMOFs), with a variety of luminescence sources from organic connectors or central metal ions, guest-induction, or charge transfer between ligands and metal ions, are often used as chemical sensing materials. − LMOFs have been widely used in the detection of chemical substances such as ions, small organic molecules, , amino acids, , and antibiotics, , as well as physical factors (pressure, pH, and temperature). ,− Compared with common detection technologies like chromatography, biological detection, capillary electrophoresis (CE), and inductively coupled plasma mass spectrometry (ICP-MS), , the luminescence-based detection method offer distinct advantages . LMOFs are proved to be ideal luminescence sensors with simple operation, good selectivity and high sensitivity. , Furthermore, the guest molecules are mainly detected by the luminescence properties of MOFs, especially compared with the fluorescence quenching (turn-off) sensors, the fluorescence enhancement (turn-on) sensors could avoid various environmental factors (such as moisture or photodegradation) and have a better signal-to-noise ratio to obtain a fast and accurate luminous signal …”

Section: Introductionmentioning

confidence: 99%

“…Luminescent metal−organic frameworks (LMOFs), with a variety of luminescence sources from organic connectors or central metal ions, guest-induction, or charge transfer between ligands and metal ions, are often used as chemical sensing materials. 1−4 LMOFs have been widely used in the detection of chemical substances such as ions, 5 small organic molecules, 6,7 amino acids, 8,9 and antibiotics, 10,11 as well as physical factors (pressure, pH, and temperature). 7,12−14 Compared with common detection technologies like chromatography, 15 biological detection, 16 capillary electrophoresis (CE), and inductively coupled plasma mass spectrometry (ICP-MS), 17,18 the luminescence-based detection method offer distinct advantages.…”

Section: ■ Introductionmentioning

confidence: 99%

Multifunctional Fluorescence Turn-On Sensor for Acetylacetone, Glyoxal, and Salicylaldehyde Based on a Highly Stable 1D → 2D Interlocked Cd(II) Metal–Organic Framework

Zhang

Cai

et al. 2023

Crystal Growth & Design

View full text Add to dashboard Cite

Metal−organic frameworks (MOFs) provide a broad platform for detecting small organic molecules due to their good stabilities and unique luminescent properties. Herein, a one-dimensional Cd II -based double chain metal−organic framework {[Cd(BBIP)(CDDB)(H 2 O)]•2H 2 O} n (JXUST-30) derived from 3,5-bis(1H-benzo[d]imidazol-1-yl)pyridine (BBIP) and 4,4′-(9H-carbazole-3,6-diyl)dibenzoic acid (H 2 CDDB) was successfully synthesized by solvothermal method. Interestingly, the Cd II −BBIP chain could pass through the large cavity formed by CDDB 2− to make parallel one-dimensional double chains interlocked, resulting in a structural transition from a one-dimensional chain to a twodimensional plane (1D → 2D) and the enhancement of structural stability. The intense blue light emission and the excellent stability in aqueous solutions with the wide range of pH values, organic solvents, and even boiling water of JXUST-30 provide a platform for detecting small organic molecules. The sensing experiments indicate that JXUST-30 can be used as a multifunctional fluorescence turn-on sensor for detecting acetylacetone (acac), aldehydes (glyoxal and salicylaldehyde (SA)) with fast response time (<15 s) and high sensitivity (detection limits of 0.068, 0.060, and 0.051 ppm, respectively). In addition, the successful preparation of sensing devices based on JXUST-30 provides the possibility for practical application in fluorescence detection of small organic molecules.

show abstract

“…15 MOFs have unique physical and chemical properties such as a large specific surface area, high porosity, thermal stability, and an adjustable pore size. 16 Several strategies have been developed for enantio-selective identification, [17][18][19] but the enantioselective electrochemical sensor is rarely reported. 20 Ionic liquids have a fascinating physiochemical nature including tunable viscosity, high thermal stability, stable broad potential window, and excellent ionic conductivity, 21,22 and have been widely used in electrochemical research.…”

Section: Introductionmentioning

confidence: 99%

Integration of a copper-based metal–organic framework with an ionic liquid for electrochemically discriminating cysteine enantiomers

Pan¹,

Zhu²,

Zhang³

et al. 2023

Analyst

View full text Add to dashboard Cite

show abstract

Specific chiral recognition of amino acid enantiomers promoted by an enzymatic bioreactor in MOFs

Abstract: Chiral recognition and quantification of amino acid (AA) enantiomers are of great significance in many fields such as biology and biomedicine. Herein, a general enzyme-driven fluorescent sensing model was proposed...

Cited by 7 publications

References 55 publications

Hierarchically Porous MOFs Synthesized by Soft-Template Strategies

Hierarchically Porous MOFs Synthesized by Soft-Template Strategies

Multifunctional Fluorescence Turn-On Sensor for Acetylacetone, Glyoxal, and Salicylaldehyde Based on a Highly Stable 1D → 2D Interlocked Cd(II) Metal–Organic Framework

Integration of a copper-based metal–organic framework with an ionic liquid for electrochemically discriminating cysteine enantiomers

Contact Info

Product

Resources

About