Specific CCND1 G870A Alleles Associated with Breast Cancer Susceptibility: a Meta-analysis of 5,528 Cases and 5,353 Controls

Cui, Jing; Shen, Liang; Wang, Yu

doi:10.7314/apjcp.2012.13.10.5023

Cited by 14 publications

(9 citation statements)

References 18 publications

(15 reference statements)

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“…The symbol filled diamond indicates pooled OR and its 95 % CI increased cancer risk associated with the cyclin D1 polymorphism [46]. Following this, four subsequent meta-analyses were conducted and showed the same results that are consistent with the initial meta-analysis [47][48][49][50]. Conversely, our study is far larger compared with any previous study, implicating an inverse finding.…”

Section: Discussionsupporting

confidence: 82%

Genetic association between cyclin D1 polymorphism and breast cancer susceptibility

Huo

et al. 2014

Tumor Biol.

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Cyclin D1 polymorphism has been reported to be associated with risk of breast cancer, but the published studies have yielded controversial results. This study was undertaken to derive a precise risk estimate for the cyclin D1 polymorphism associated with breast cancer risk. We performed a search of EMBASE, PubMed, and Web of Science. In total, data from 18 publications were pooled and the association was assessed by odds ratios (ORs) with 95 % confidence intervals (CIs). This analysis showed that there was no obvious association between the cyclin D1 polymorphism and breast cancer risk in any of the analyzed genetic model. We found the same negative association in stratified analyses by ethnicity, source of controls, and sample size. Our meta-analysis provides an estimate that the presence of cyclin D1 polymorphism may not confer susceptibility to breast cancer.

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Section: Discussionsupporting

confidence: 82%

Genetic association between cyclin D1 polymorphism and breast cancer susceptibility

Huo

et al. 2014

Tumor Biol.

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“…For example, several meta-analyses studies have reported associations of the CCND1 G870A genetic polymorphism with increased susceptibilities to colorectal, lung, breast, and bladder cancers (Cui et al, 2012;Yang et al, 2012;Zhou et al, 2013;Wang et al, 2014). Notably, while the majority of previous studies observed that the AA genotype contributed to increased cancer risk, for MM, the GG genotype seemed to confer increased risk as reported here and by others (Weinhold et al, 2013).…”

Section: Discussioncontrasting

confidence: 37%

“…In addition to genetic mutations and chromosomal abnormality, a number of single nucleotide polymorphisms (SNPs) in the CCND1 gene such as G870A at the exon 4 splice site were associated with an increased risk and poor prognosis in several types of tumors (Cui et al, 2012;Yang et al, 2012;Zhou et al, 2013;Wang et al, 2014). However, the link between CCND1 SNPs and MM susceptibility is unclear.…”

Section: Introductionmentioning

confidence: 99%

Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma

Wang¹,

Huang²,

Su³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Cyclin D1 is an important cell cycle regulator implicated in the pathogenesis of many cancer types. In particular, translocation and overexpression of cyclin D1 are common events in multiple myeloma (MM), suggesting that it may drive the initiation and progression of this malignancy. However, the association between genetic polymorphisms of cyclin D1 and the risk for developing MM remains poorly characterized. We performed a case-control study with 67 patients with MM and 66 healthy controls in a Chinese population. The cancerassociated G870A single nucleotide polymorphism (SNP) of CCND1, the gene encoding cyclin D1, was determined by polymerase chain reaction and restriction fragment length polymorphism. We found that there was a strong association between the homozygous variant allele Cyclin D1 and multiple myeloma (GG) and MM susceptibility, with an odds ratio (OR) of 4.679 [95% confidence interval (CI): 1.081-5.647]. When further stratified analysis was performed, the increased risk was only evident in individuals over 60 years old (OR=3.297; 95%CI: 1.058-10.276). Our results suggest that the CCND1 G870A SNP may be critically involved in MM development.

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“…This variant may have a longer half-life than the c.723G variant, which may cause the G 1 /S-checkpoint bypass ( 11 ). Published data concerning the association between the c.723G>A polymorphism and the neoplastic process remains inconclusive, although several meta-analyses postulate the presence of a correlation between the c.723A allele and various types of cancers, including breast, gastric, bladder and cervical cancer or squamous cell carcinoma of the head and neck ( 17 – 20 ). Absenger et al revealed that, in the validation set, the c.723A allele remained significantly associated with a decreased time to tumor recurrence in univariate and multivariate analyses in patients with colon cancer.…”

Section: Discussionmentioning

confidence: 99%

CCND1 gene polymorphic variants in patients with differentiated thyroid carcinoma

et al. 2014

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Alterations in the CCND1 gene affect the cell cycle and are frequently observed in a variety of cancers. While the most frequent mutations that occur in thyroid tumor tissue have been characterized, the genetic factors that predispose individuals to differentiated thyroid cancer (DTC) remain to be elucidated. The present study examined whether the CCND1 c.723G>A (rs9344; p.Pro241=) and c.669C>T (rs3862792; p.Phe223=) variants have an impact on DTC susceptibility. A cohort consisting of 652 patients diagnosed with DTC were analyzed and comapred with a reference group of 799 subjects from the general population. Pyrosequencing was used as the genotyping technique. In order to determine the statistical significance of differences observed in the genotypic and allelic frequencies between the compared groups, GraphPad Prism 4 was used. At the rs9344 locus in the DTC patients, a higher frequency of allele A [P=0.032; odds ratio (OR), 1.18; 95% confidence interval (CI), 1.014–1.361] and the AA homozygous genotype (P=0.028; OR, 1.41; 95% CI, 1.059–1.989) was observed compared with the control population group. The differences were stronger for papillary carcinomas (OR 1.45; 95% CI, 1.059–1.989), but were not significant in follicular tumors. No statistically significant differences were noted in the frequency of genotypes or alleles at the rs3862792 locus in the examined groups. The present findings indicate that the c.723A variant of the CCDN1 gene may be a susceptibility low penetrance allele in the development of papillary thyroid cancer in the population studied, however it does not impact on multifocality, metastatic ability or age at diagnosis. A cumulative effect of the analyzed CCND1 gene variants was also excluded.

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Specific CCND1 G870A Alleles Associated with Breast Cancer Susceptibility: a Meta-analysis of 5,528 Cases and 5,353 Controls

Cited by 14 publications

References 18 publications

Genetic association between cyclin D1 polymorphism and breast cancer susceptibility

Genetic association between cyclin D1 polymorphism and breast cancer susceptibility

Cyclin D1 G870A polymorphism is associated with an increased risk of multiple myeloma

CCND1 gene polymorphic variants in patients with differentiated thyroid carcinoma

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