Specific Capacitance of Metal Supported Lipid Membranes

Passechnik, V.I.; Hianik, Tibor; Ivanov, S. A.; Sivak, Branislav

doi:10.1002/(sici)1521-4109(199804)10:5<295::aid-elan295>3.0.co;2-7

Cited by 35 publications

(7 citation statements)

References 17 publications

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“…The use of wires of diameter of 0.25 mm have resulted in background ion currents that had high noise levels for periods of over 90 min. This shows that the electrical parameters of these BLMs were highly unstable which is in agreement with previous published results [17]. In addition, these BLMs had a high mechanical instability.…”

Section: Resultssupporting

confidence: 92%

A Minisensor for the Rapid Screening of Acesulfame-K, Cyclamate, and Saccharin Based on Surface-Stabilized Bilayer Lipid Membranes

Nikolelis

Pantoulias

2000

Electroanalysis

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This work describes an electrochemical technique that is suitable for the rapid and sensitive screening of the sweeteners acesulfame‐K, cyclamate and saccharin based on surface‐stabilized bilayer lipid membranes (s‐BLMs) composed from egg phosphatidylcholine (PC). The interactions of the sweeteners with s‐BLMs which produced a reproducible electrochemical ion current signal increase appeared within a few s after exposure of the membranes to the sweetener. The current signal increases were related to the concentration of the sweetener in bulk solution in the micromolar range. The present lipid film based sensor provided fast response (i.e., on the order of a few s) to alterations of acesulfame‐K, cyclamate and saccharin concentration (1 to 15, 10 to 160 and 0.4 to 7 μM) in electrolyte solution. The electrochemical transduction of the interactions of these artificial sweeteners with s‐BLMs was applied in the determination of these compounds in granulated sugar substitute products by using the present minisensor.

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Section: Resultssupporting

confidence: 92%

A Minisensor for the Rapid Screening of Acesulfame-K, Cyclamate, and Saccharin Based on Surface-Stabilized Bilayer Lipid Membranes

Nikolelis

Pantoulias

2000

Electroanalysis

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“…The use of wires of diameter of 0.25 mm have resulted in background ion currents that had high noise levels for periods of over 90 min. This shows that the electrical parameters of these BLMs were highly unstable which is in agreement with previous published results [23]. In addition, these BLMs had a high mechanical instability.…”

Section: Electrochemical Investigation Of Interactions Of Metal-supposupporting

confidence: 92%

Biosensors for the Rapid Detection of Dopamine Using Bilayer Lipid Membranes (BLMs) With Incorporated Calix[4]resorcinarene Receptor

et al. 2002

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This work explores the use of a calix[4]resorcinarene receptor (lipophilic macrocyclic host molecule) for the rapid electrochemical detection of dopamine using planar bilayer lipid membranes (BLMs). BLMs were composed of egg phosphatidylcholine (PC) and 35% (w/w) dipalmitoyl phosphatidic acid in which the receptor was incorporated. Freely‐suspended and metal supported BLMs modified with the resorcin[4]arene receptor were used as one shot sensors to rapidly detect this catecholamine. The interactions of this compound with freely‐suspended BLMs were found to be electrochemically transduced in the form of a transient current signal with duration of seconds, which reproducibly appeared within 8 s after exposure of the membranes to dopamine. The response time for these BLMs without incorporated receptor for dopamine was about 3 min. The magnitude of the transient current signal was related to the concentration of the stimulating agent in bulk solution in the micromolar range. The present electrochemical technique was also applied for the rapid and sensitive screening of dopamine using surface‐stabilized bilayer lipid membranes (sBLMs). The interactions of dopamine with sBLMs with incorporated receptor produced electrochemical ion current increases, which reproducibly appeared within a few seconds after exposure of the membranes to the stimulant. The use of the receptor in sBLMs increased the sensitivity of the method by 10‐fold. The current signal increases were related to the concentration of dopamine in bulk solution in the micromolar range. No interferences from ascorbic acid were noticed because of the use of the negatively charged lipids in membranes. The present technique can be used as one‐shot sensor for the rapid detection of these pharmaceutical substances and keep prospects for the selective determination of catecholamines in biofluids.

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“…Potentiometric Preprints (www.preprints.org) | NOT PEER-REVIEWED | Posted: 9 October 2018 doi:10.20944/preprints201810.0175.v1 experiments (against a Ag/AgCl reference electrode) [5] showed only small voltages (relative to a silver wire against a Ag/AgCl reference electrode) when the BLM had been removed using an organic solvent rinse. These results suggest that (a) the metal surface is possibly coated with a thin layer of silver chloride and (b) the lipid membrane actually consists of a network of nm-sized BLMs [8].…”

Section: Metal Supported Lipid Membranesmentioning

confidence: 87%

Lipid Membrane Based Biosensors

Nikoleli¹,

Nikolelis²,

Siontorou³

et al. 2018

Preprint

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The exploitation of lipid membranes in biosensors has provided the ability to reconstitute a considerable part of their functionality to detect trace of food toxicants and environmental pollutants. Nanotechnology enabled sensor miniaturization and extended the range of biological moieties that could be immobilized within a lipid bilayer device. This chapter reviews recent progress in biosensor technologies based on lipid membranes suitable for environmental applications and food quality monitoring. Numerous biosensing applications are presented, putting emphasis on novel systems, new sensing techniques and nanotechnology-based transduction schemes. The range of analytes that can be currently detected include, insecticides, pesticides, herbicides, metals, toxins, antibiotics, microorganisms, hormones, dioxins, etc. Technology limitations and future prospects are discussed, focused on the evaluation/ validation and eventually commercialization of the proposed sensors.

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Specific Capacitance of Metal Supported Lipid Membranes

Cited by 35 publications

References 17 publications

A Minisensor for the Rapid Screening of Acesulfame-K, Cyclamate, and Saccharin Based on Surface-Stabilized Bilayer Lipid Membranes

A Minisensor for the Rapid Screening of Acesulfame-K, Cyclamate, and Saccharin Based on Surface-Stabilized Bilayer Lipid Membranes

Biosensors for the Rapid Detection of Dopamine Using Bilayer Lipid Membranes (BLMs) With Incorporated Calix[4]resorcinarene Receptor

Lipid Membrane Based Biosensors

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