Specific Behavioral Patterns Enhancing Hypoxia Resistance in Wistar Rats Subjected to Moderate Swimming Exercise

Kondashevskaya, M. V.

doi:10.1007/s10517-020-04851-4

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“…As shown in our previous studies, moderate physical loads (swimming) allowed tolerant behavior conditioning in most of Wistar rats in the population. At the same time, it was established that animals adopted to tolerant strategy, became HT, while unlearned rats turned out to be LT [ 39 ]. Given that tolerance to hypoxia is genetically fixed and MT rats are probably the most tolerant to hypoxia, it can be assumed that MT rats, which learned the strategy of tolerance as the main principle of their behavior, became HT animals.…”

Section: Discussionmentioning

confidence: 99%

Indicators of Hypoxia Tolerance as Determined by Cellular Elements of Rat Blood

Kondashevskaya

Artemieva

Алексанкина

et al. 2021

J Evol Biochem Phys

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Although hypoxia tolerance is mainly determined genetically, it is important to study individual variability of animal organisms in order to identify the factors that underlie their tolerance to hypoxic exposure. We investigated blood cell counts and coagulograms in Wistar rats as predictors allowing the animal population to be split into hypoxia-tolerant and hypoxia-intolerant individuals. The validity of the specific predictors’ choice was proved by a coincidence between the population split in accordance with the detected individual parameters and the results of testing animals in a decompression chamber at a rarefaction corresponding to the “rise to an altitude” of 11500 m above sea level. Circulating blood cells were quantitatively assessed by eighteen indicators before and after hypoxic exposure. The differences between animals low-tolerant (LT), high-tolerant (HT), and medium-tolerant (MT) to hypoxia were determined by five indicators: white blood cell count (WBC), granulocyte count (Gran#), red blood cell count (RBC), reticulocyte count/percent (RTC), and mean corpuscular hemoglobin (MCH). The RBC, RTC, and MCH values in HT rats were significantly higher than in LT animals (by 1.4, 1.9, and 1.1 times, respectively). The WBC and Gran# values in HT rats were lower than in LT individuals. The hypoxia tolerance indices (HTI) were calculated using the original formula. It was established that in LT rats, the HTI ≤ 0.203, in HT rats ≥ 0.335, and in MT rats < 0.335 but > 0.203. After testing in a decompression chamber, the activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT) decreased, but the fibrinogen level increased. LT rats were characterized by the lowest APTT, TT, and PT values and the highest values of the fibrinogen level. Our results indicate that one of the most important mechanisms underlying a high hypoxia tolerance in rats consists in sustaining reciprocal relationships between the complex of RBC indicators, which tend to increase under hypoxia, and Gran# indicators, which tend to decrease after hypoxic exposure.

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Section: Discussionmentioning

confidence: 99%