Specific Associations Between Clinical Signs, Immune Cells, Disease Genetic Background and Burden in a Group of Patients with B-Cell Chronic Lymphocytic Leukemia

Abstract

Traffic of tumor-and normal cells through the peripheral blood (PB) of patients with B-cell chronic lymphocytic leukemia (B-CLL) to the lymph nodes (LN) or spleen/ liver sites is governed by specific changes in CCR7, CXCR5, CXCR3, CCR4, CD3, CD4, CD8, CD27, CD28, CD45RA, CD25, CD127, CD38 was also report a significant increase in the frequency of total T cells and T cell subsets (effector-and central memory CD4+ T cells, regulatory T cells, follicular T helper cells, distinct functional CD8+ T cells) with the occurrence of specific clinical manifestations. Chemokine receptor expression on circulating CD4+ T cell subsets was augmented in connection to

Atypical case of B-cell Chronic Lymphocytic Leukemia presenting with extreme hyperleukocytosis / Hiperleucocitoză extremă într-un caz atipic de leucemie limfatică cronică cu celulă B

“…The typical CLL also expresses CD23 without FMC7 and shows dim expression of CD20 and dim surface immunoglobulin (sIg) expression. MCL typically expresses bright CD20 and bright to moderate sIg, lacks CD23, and is FMC7+ (16,17,18). Atypical-CLL phenotype is the category of clonal B cells that express CD5, but other markers are differentially expressed as compared with CLL: CD5+CD19+, but CD23 weak of negative or CD20, sIg or CD79b bright (19).…”