2017
DOI: 10.1590/0074-02760160505
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Specific antigen serologic tests in leprosy: implications for epidemiological surveillance of leprosy cases and household contacts

Abstract: BACKGROUND There is a lack of straightforward tests for field application and known biomarkers for predicting leprosy progression in infected individuals.OBJECTIVE The aim was to analyse the response to infection by Mycobacterium leprae based on the reactivity of specific antigens: natural disaccharide linked to human serum albumin via an octyl (NDOHSA), a semisynthetic phenolic glycolipid-I (PGL-I); Leprosy Infectious Disease Research Institute Diagnostic-1 (LID-1) and natural disaccharide octyl - Leprosy Inf… Show more

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Cited by 11 publications
(11 citation statements)
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“…The antigens NDO-HSA, LID-1 and NDO-LID have been also used in surveillance studies targeting household contacts ( 36 , 37 ). Leprosy household contacts represent a group at high risk of developing the disease, thus, tracking new cases among this population contributes for early detection and better control of the disease ( 38 , 39 ).…”
Section: Discussionmentioning
confidence: 99%
“…The antigens NDO-HSA, LID-1 and NDO-LID have been also used in surveillance studies targeting household contacts ( 36 , 37 ). Leprosy household contacts represent a group at high risk of developing the disease, thus, tracking new cases among this population contributes for early detection and better control of the disease ( 38 , 39 ).…”
Section: Discussionmentioning
confidence: 99%
“…Studies in different regions of Brazil and South America have found similar situations, which confirm that the serology varies according to the degree of endemic of the geographic region, genetic predisposition of the population and level of proximity to the leprosy patient, in the case of household and social contacts (5,10) . The results of the research revealed that the health services performed late and inopportune diagnoses, due to the presence of changes in foot strength after treatment.…”
Section: Discussionmentioning
confidence: 54%
“…The profile of household contacts with positive serology -men over 60 years and spouses of the index case -also suggests that the length of time and exposure to the focus of the infection puts them at risk of acquiring the disease (5,15) , corroborating the affirmation that a set of factors greatly influence the transmission of Mycobacterium leprae, in addition to the clinical features of the index case (10) .…”
Section: Discussionmentioning
confidence: 65%
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