Specific and Non-Specific Stimulation of Peripheral Lymphocytes

Ling, N. R.; Husband, E. M.

doi:10.1016/s0140-6736(64)92102-6

Cited by 106 publications

(23 citation statements)

References 28 publications

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“…It seems unlikely that a similar inhibition would always result from immunization with killed vaccines, toxoids or proteins because of the frequency with which blast transformation has been reported following such immunizations, even in experiments employing autologous plasma. For instance Ling and H usband (9) observed mitogenesis with tetanus toxoid in cultures containing lymphocytes and plasma from an individual immunized 10 weeks previously, and whose serum-antibody titer was 1/16000 by indirect hemagglutination. In the same study, however, lymphocytes from an individual who had received three injections of typhoid-paratyphoid vaccine, with a direct agglutination titer of 200 (H antigen) and 160 (0 antigen) did not undergo transformation when cultured with typhoid-paraty phoid antigens.…”

Section: Resultsmentioning

confidence: 99%

Inhibition of Tuberculin-Induced Mitogenesis in Cultures of Lymphocytes from Tuberculous Donors

Heilman¹,

McFarland²

1966

Int Arch Allergy Immunol

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Section: Resultsmentioning

confidence: 99%

Inhibition of Tuberculin-Induced Mitogenesis in Cultures of Lymphocytes from Tuberculous Donors

Heilman¹,

McFarland²

1966

Int Arch Allergy Immunol

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“…The substances causing these changes may be non-specific mitogens of plant origin [see review by Barker, 1969], antigens against which the donor is sensitized, transplantation antigens, antibodies against determi nants on the lymphocyte surface and agents such as streptolysin S and staphylococcal exotoxins [Ling and H usband, 1964;R obbins, 1964;Y offey, 1967]. Although the broad outline of the response to all these stimuli is similar, the detailed morphological and biochemical changes in the lymphocyte vary from substance to substance.…”

Section: Introductionmentioning

confidence: 99%

Lymphocyte Mitogens of Indigenous Australian Plant Species

Curtain¹,

Simons²

1972

Int Arch Allergy Immunol

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Saline extracts of seeds from 164 Australian indigenous plant species representing 73 genera and 28 families were tested for their ability to stimulate blast transformation and mitosis in human buffy coat cells. Extracts from 3 species, Rhagodia crassifolia, Bassia decurrens and Bauhinia Carronii were found to be active. The most active extract, from B. Carronii was fractionated by isoelectric focussing, by which it was found possible to separate the mitogenic, haemagglutinating and leucoagglutinating activities. The activity of the B. Carronii mitogen was not inhibited by antiserum to the phytohaemagglutinin of Phaseolus vulgaris (PHA) and its chemical composition and sedimentation co-efficient differed from those published for PHA and the mitogen of the pokeweed (Phytolacca americana).

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“…These and other workers have demonstrated similar in vitro changes in peripheral leukocytes brought about by antigens to which the subject had been immunized (17)(18)(19)(20)(21)(22)(23)(24)(25)(26), by extracts of autologous tissues in patients with autoimmune diseases (15,26,27), antisera from rabbits immunized to human leukocytes (28,29), and by phytohemaggiutinin M (12,25,(30)(31)(32)(33)(34)(35)(36)(37). The response to the latter was found to be most intense.…”

mentioning

confidence: 53%