Specific and Non-specific Clinical Presentations in the Year Before the Diagnosis of Childhood Leukaemia

Abstract

We described a clinical picture in the year before leukaemia diagnosis. These findings revealed ongoing difficulties in early diagnosis of childhood leukaemia in healthcare settings.

Time-dependent associations between presentation-based infections and subsequent risk of childhood immune cell malignancies

“…However, it is known that children with immune cell malignancies develop multiple presentations prior to malignancy diagnosis, and some presentations could either mimic infection or be caused by infection (11). An apparent association could be spurious due to infection as a presentation of immune cell malignancies.…”

Childhood cancer, type 1 diabetes and other immune diseases: healthcare visits in the year before diagnosis in Taiwan

“…Among the 10 conditions which included cancer at seven sites and three immune diseases, recent increases (>threefold) in organ-specific presentations shortly before the diagnosis of bone cancer,8 soft tissue cancer, ovarian cancer,9 and brain tumour,1 and brain tumour, and general presentations of urogenital problems and apparent injuries before the diagnosis of lymphoma,10 acute lymphoid leukaemia,2 and systemic lupus erythematosus,11 were generally in line with known clinical presentations of each condition. This may suggest that children with known presentations were missed at these clinic visits.…”

“…A case-only study on childhood brain tumours in the UK1 and our recent case-control study on childhood leukaemia in Taiwan2 both reported increasing rates of healthcare visits in the months before the diagnosis. To our knowledge there have been no reports for other diseases.…”

Fieber während der Granulozytopenie bei krebskranken Kindern und Jugendlichen

“…Wichtig ist jedoch auch die Dynamik der Granulozytenzahlen im peripheren Blut: Fallende Werte mit einer in den nächsten Tagen erwarteten Granulozytopenie sind mit einem höheren, steigende Werte mit einem niedrigeren Risiko für kompliziert verlaufende Infektionen assoziiert [1]. Neben Neben der Chemotherapie kann auch die Grunderkrankung Wochen oder sogar Monate vor der eigentlichen Diagnosestellung eine Granulozytopenie verursachen, da Tumorzellen im Knochenmark die normale Blutbildung verdrängen [18].…”