Specific airway resistance in 3-year-old children: a prospective cohort study

Lowe, Lesley; Murray, Clare; Čustović, Adnan; Simpson, B.; Kissen, Patricia; Woodcock, Ashley

doi:10.1016/s0140-6736(02)08781-0

Cited by 138 publications

(115 citation statements)

References 25 publications

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“…We (5,15,16) and others (17)(18)(19) have reported that children with persistent wheeze are more likely than transient early wheezers to have high serum IgE levels, eosinophilia, and skin test reactivity to local aeroallergens. Lowe and coworkers (20) showed that, regardless of the development of early respiratory symptoms, children with a strong family history of asthma who had become sensitized to local allergens had significantly lower specific airway conductance at age 3 yr compared with nonsensitized children. It is thus tempting to speculate that the early development of allergic immune responses in the airways may facilitate a process of physiologic remodeling occurring at a time of fast lung and airway growth.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Asthma and Wheezing in the First 6 Years of Life

Morgan

Stern

Sherrill

et al. 2005

Am J Respir Crit Care Med

596

417

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Rationale: The effect of early life wheezing on respiratory function and continued symptoms through adolescence has not been fully described. Using data from a population-based birth cohort in Tucson, Arizona, we previously described four phenotypes based on the occurrence of wheezing lower respiratory illnesses before age 3 yr and active wheeze at age 6 yr: never wheezers (n ϭ 425), transient early wheezers (n ϭ 164), persistent wheezers (n ϭ 113), and lateonset wheezers (n ϭ 124). Objective: We sought to determine the prognosis for these phenotypes, with reference to lung function and symptoms, through adolescence. Methods: Current wheeze was assessed by questionnaire, lung function was measured by conventional spirometry, and atopy was determined by skin prick tests. Results: The prevalence of atopy and wheeze by age 16 yr was similar for never and transient wheezers and for persistent and late-onset wheezers. Both transient early, and persistent wheezers had significantly lower FEF 25-75 (-259 ml/s, p Ͻ 0.001, and -260 ml/s, p ϭ 0.001, respectively), FEV 1 (-75 ml, p ϭ 0.02, and -87 ml, p ϭ 0.03, respectively), and FEV 1 :FVC ratio (-1.9%, p ϭ 0.002, and -2.5%, p ϭ 0.001, respectively) through age 16 yr compared with never wheezers. Late-onset wheezers had levels of lung function similar to those of never wheezers through age 16 yr. There was no significant change in lung function among subjects with any of the four phenotypes, relative to their peers, from age 6 to 16 yr. Conclusion: Patterns of wheezing prevalence and levels of lung function are established by age 6 yr and do not appear to change significantly by age 16 yr in children who start having asthmalike symptoms during the preschool years.

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Section: Discussionmentioning

confidence: 99%

Outcome of Asthma and Wheezing in the First 6 Years of Life

Morgan

Stern

Sherrill

et al. 2005

Am J Respir Crit Care Med

596

417

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“…This showed that being in the high-risk group and/or atopic at age 3 was significantly associated with increased sRaw (i.e. poorer lung function) (69).…”

Section: Environmental Intervention -Aeroallergen Avoidancementioning

confidence: 89%

Can we prevent allergy?

Gore

Čustović

2004

Allergy

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Allergic conditions continue to increase steeply. The last two decades have seen many prevention trials, studying the effect of dietary and environmental interventions. These trials have yielded invaluable information about the atopic march and also highlighted the need for a clear and commonly used nomenclature as well as a need for better outcome measures. This review discusses primary and secondary prevention studies and their results.

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“…In the MAAS group, at age 3 years, sGaw was measured using whole-body plethysmography (n ¼ 466) (26,27).…”

Section: Data Sources and Measurementmentioning

confidence: 99%