Specific adverse effects of antiepileptic drugs — A true-to-life monotherapy study

Kowski, Alexander B.; Weißinger, Florian; Gaus, Verena; Fidzinski, Pawel; Losch, Florian; Holtkamp, Martin

doi:10.1016/j.yebeh.2015.11.009

Cited by 67 publications

(48 citation statements)

References 34 publications

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“…Anger appeared to be a particular problem of LEV, which was missed in the regulatory trials 23 but is now increasingly recognized as LEV add-on 24,25 and monotherapy. 20 Our study detected also a significant association of depression with CBZ. In the SANAD study, LTG was also better tolerated than CBZ.…”

Section: Discussionsupporting

confidence: 62%

“…The LAEP has been used in Spain, 16 China, 17 Brazil, 18 Korea 19 and Germany. 20 A common theme emerged. The mean LAEP scores were higher in patients with uncontrolled epilepsy 18 and in patients with depression 19,21 indicating that not all self-reported symptoms are caused by AEDs.…”

Section: Discussionmentioning

confidence: 99%

“…The LAEP has been used in Spain,16 China,17 Brazil,18 Korea 19 and Germany 20. The LAEP has been used in Spain,16 China,17 Brazil,18 Korea 19 and Germany 20.…”

mentioning

confidence: 99%

“…The LAEP has been used in Spain,16 China,17 Brazil,18 Korea 19 and Germany 20. Anger appeared to be a particular problem of LEV, which was missed in the regulatory trials 23 but is now increasingly recognized as LEV add-on24,25 and monotherapy 20. The mean LAEP scores were higher in patients with uncontrolled epilepsy 18 and in patients with depression19,21 indicating that not all self-reported symptoms are caused by AEDs.…”

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confidence: 99%

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Efficacy and tolerability of anti-epileptic drugs-an internet study

Wieshmann

Baker

2016

Acta Neurol Scand

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Section: Discussionsupporting

confidence: 62%

Section: Discussionmentioning

confidence: 99%

“…The LAEP has been used in Spain,16 China,17 Brazil,18 Korea 19 and Germany 20. The LAEP has been used in Spain,16 China,17 Brazil,18 Korea 19 and Germany 20.…”

mentioning

confidence: 99%

mentioning

confidence: 99%

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Efficacy and tolerability of anti-epileptic drugs-an internet study

Wieshmann

Baker

2016

Acta Neurol Scand

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“…The anti‐epileptic drugs (AEDs) are used as medications to prevent or control seizures and convulsions. Although in recent decades, many new drugs have been provided for the treatment of epilepsy, these drugs have shown to have side effects and are even harmful, which in most cases, further, cannot—even with adequate doses—properly stave off seizures; hence, they do have very negative impacts on the quality of one's life . Therefore, a constant need to discover and develop new AEDs is felt more than ever.…”

Section: Introductionmentioning

confidence: 99%

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

Allahyari

Hosseini

Azizi

2019

Neurology & Clinical Neurosc

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Background The genus Tanacetum is widespread in Europe and Western Asia. It is an important traditional plant which has been used in the treatment of many illnesses. Aim In the present study, the effect of the hydroalcoholic extract of Tanacetum polycephalum (henceforth TP) on the animal model of seizure was studied. Methods In this experimental study, 42 male Wistar rats weighing 220‐250 g were randomly selected and were divided to experimental and control groups (six rats per group). The experimental groups were treated by intraperitoneal (ip) single injection of 150, 300, 450, 600, and 750 mg kg−1 of hydroalcoholic extracts of TP. The control negative group received normal saline (0.9%) and the control positive group received phenobarbital (30 mg kg−1, ip) pretreatment. 30 minutes after the treatments, the seizure behaviors were evaluated by pentylenetetrazol (PTZ; 70 mg kg−1, ip) challenge. In addition, after experiment, the rats were put to death and brain was removed for the histological study. Results The ANOVA test was showed that compared to control group, all the TP doses delayed the initiation and duration of the tonic, clonic, and tonic‐clonic seizures and significantly reduced the tonic and clonic seizures (P < 0.001). Furthermore, the administration of all five doses of the extract significantly prevented the production of the dark neurons (P < 0.001) in different areas of the hippocampus compared to PTZ group. Conclusions We can conclude that the TP extract has beneficial effects on the prevention of the PTZ‐induced seizure.

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Impact of depressive symptoms on adverse effects in people with epilepsy on antiseizure medication therapy

Panholzer,

Hauser,

Thamm

et al. 2024

Epilepsia Open

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ObjectiveWe studied the impact of depressive symptoms on adverse effects (AEs) in people with epilepsy (PWE) on antiseizure medication (ASM) therapy. An effect of depression on the AE burden has already been reported. We studied the correlation of various depressive symptoms with specific AEs to assess which AEs are especially prone to being confounded by particular depressive symptoms.MethodsPWE filled in a variety of questionnaires including the “Neurological Disorder Depression Inventory for Epilepsy” (NDDI‐E), “Emotional Thermometers 4” (ET4) and “Liverpool Adverse Events Profile” (LAEP). Depression was defined by a NDDI‐E score > 13. Depressive symptoms consisted of NDDI‐E and ET4 items. Discriminant analysis identified those AEs (=LAEP items) that were most highly influenced by depression. Logistic regression analysis yielded correlations of different depressive symptoms with specific AEs.ResultsWe included 432 PWE. The strongest discriminators for depression were the LAEP items “Depression”, “Nervousness/agitation,” and “Tiredness”. Out of all depressive symptoms “Everything I do is a struggle” most strongly correlated with total LAEP score (odds ratio [OR] = 3.1) and correlated with all but one LAEP item. Other depressive symptoms correlated to varying degrees with total LAEP and item scores. The number of ASMs, lack of seizure remission, and female gender correlated with high LAEP scores.SignificanceTo the best of our knowledge, we are the first to show that various depressive symptoms correlate with specific LAEP items. This information can be helpful for quick evaluation of whether the reporting of different LAEP items may be confounded by particular depressive symptoms. This is relevant because changes in therapy may differ depending on if AEs are confounded by depressive symptoms. Simply reporting a particular depressive symptom may give a clue to whether specific AEs are confounded by depression. Our findings confirm the importance of screening for depression in all PWE.Plain Language SummaryIn this study we measured depressive disorder and side effects caused by medication used to treat epilepsy with self‐reported questionnaires in a cohort of people with epilepsy. We found depressive disorder to influence the perception of side effects that are caused by drugs used to treat epilepsy. This knowledge can help to identify if the reporting of side effects is influenced by depression. Treating depression may help to reduce side effects and may thus increase the tolerability of anti‐epileptic medication. People who tolerate their medication are more likely to take it and are thus less likely to develop epileptic seizure.

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Specific adverse effects of antiepileptic drugs — A true-to-life monotherapy study

Cited by 67 publications

References 34 publications

Efficacy and tolerability of anti-epileptic drugs-an internet study

Efficacy and tolerability of anti-epileptic drugs-an internet study

The anticonvulsant and neuroprotective effects of the Tanacetum Polycephalum hydroalcoholic extract against the experimental pentylenetetrazol‐induced model of the seizures in the male Wistar rats

Impact of depressive symptoms on adverse effects in people with epilepsy on antiseizure medication therapy

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