Species-specific differences in the glucocorticoid receptor transactivation function upon binding with betamethasone-esters

Local controlled release of corticosteroids extends surgically induced joint instability by inhibiting tissue healing

“…This is in contrast to the weight gain through enhanced fluid retention and increased appetite found in human patients (Tataranni et al, ). The mechanism behind this discrepancy is difficult to pinpoint but may be explained by species differences in receptor binding (Su et al, ) and/or signalling (Young, Yoxall, & Wagner, ) or differences in balance between mineralocorticoid and glucocorticoid activities of the drug (Nakabayashi et al, ; Tanigawa et al, ; Zhu et al, ). Glucocorticoids can induce muscle atrophy in rodents at relatively low concentrations (Sato et al, ) and hence might elicit weight loss at undetectable systemic concentrations.…”

Assessment of signal transducer and activator of transcription 6 as a target of glucocorticoid action in human airway epithelial cells

“…As Biola et al point out in their paper, ‘the effect of GC on STAT6 transcriptional activity may (thus) depend on the promoter context, and also probably on the cell type.’ Furthermore, concentrations of IL‐4 (5 ng/mL) at which there is no inhibition of STAT6‐dependent luciferase activity by GC are used to show physical association between STAT6 and GR in the co‐immunoprecipitation experiments. Murine and human GR differ slightly in primary amino acid sequence, and species differences in function have also been shown [69]. This may explain the difference in the ability of GC to affect STAT6 function.…”

Update on glucocorticoid action and resistance

“…164 It is important to confirm these studies in human cells because there are distinct differences between human and rodent GRs. 165 Cross-talk with AP-1…”