Species-related variations in tissue antioxidant status—I. Differences in antioxidant enzyme profiles

Godin, David V.; Garnett, Maureen E.

doi:10.1016/0305-0491(92)90399-c

Cited by 49 publications

(18 citation statements)

References 22 publications

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“…Yuan et al [28] reported that the tissue antioxidant enzymes in the Japanese quail were minimally affected by dietary treatment. In the present study, we also failed to detect CAT activity in quail red cells and liver tissue because of the low level of CAT activity in this species [27,28].…”

Section: Discussioncontrasting

confidence: 70%

“…Antioxidant enzyme activity profiles in red cells of man, rabbit, quail, pig and rat have been investigated and quail red cells were found to contain negligible CAT activity [26,27] but the highest levels of GSH-Px of all the species examined [27]. Yuan et al [28] reported that the tissue antioxidant enzymes in the Japanese quail were minimally affected by dietary treatment.…”

Section: Discussionmentioning

confidence: 99%

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Effects of Dietary Chicken Grill Oil and Sunflower Seed Oil on Blood and Liver Oxidant/Antioxidant Status and Liver Function Tests in Laying Japanese Quails (Coturnix coturnix japonica)

Büyükoğlu¹

2014

Turk J Bioch

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Effects of dietary chicken grill oil and sunflower seed oil on blood and liver oxidant/antioxidant status and liver function tests in laying Japanese quails (Coturnix coturnix japonica) [ ABSTRACTObjective: To investigate influence of dietary chicken grill oil (CGO) on blood and liver oxidant/ antioxidant status and parameters of liver function in laying Japanese quails (n=192; 13-wk old) (Coturnix coturnix japonica). Methods: Four groups were fed with experimental diets contained, 5% sunflower seed oil (SO 1 ), 5% chicken grill oil (CGO 1 ), 7.5% sunflower seed oil (SO 2 ) and 7.5% chicken grill oil (CGO 2 ), respectively. Experimental diets and water were provided ad libitum throughout the nine weeks of experiment. Results:The added CGO supplementation lowered erythrocyte and liver superoxide dismutase (SOD) activity, but increased erythrocyte glutathione peroxidase (GSH-Px) activity. However, the supplemented CGO did not affect to serum and liver malondialdehyde (MDA) levels. But liver MDA level of the group added 7.5% SO (SO 2 ) significantly increased compared to other groups (p<0.01). Vitamin A and β-carotene concentrations in plasma of laying quails significantly decreased due to increased rates (from 5% to 7.5%) of both CGO and SO. However, plasma vitamin E concentrations in quails fed with diets supplemented with 7.5% SO and CGO were significantly higher (p<0.05) than in birds fed with the 5% SO and CGO diets. In the analysis of liver function, serum alanine transaminase (ALT) activity in birds fed diets supplemented with CGO (CGO 1 and CGO 2 ) increased. Also, serum aspartate transaminase (AST) activity showed a significant increase (p<0.01) in quails fed with 7.5% SO or CGO. Conclusion:The results suggest that the antioxidant effect of CGO is not less effective than that SO. Both SO and CGO added to quail diets in 7.5 % ratio are not the positive effect on the oxidant/ antioxidant status and liver function tests. However, the oxidant effect of dietary 7.5% CGO is lower than that SO. Therefore CGO obtained as described in the Material-Methods section up to 5% may be added to quail diets. Key Words: Chicken grill oil, antioxidant status, liver function, quail Conflict of Interest: The authors declare no conflict of interest. ÖZETAmaç: Bu çalışmada 13 haftalık yumurtlayan Japon bıldırcınlarının (n=192) (Coturnix coturnix japonica) karma yemlerine eklenen tavuk çevirme yağının (CGO) kan ve karaciğer oksidan/antioksidan denge ve karaciğer fonksiyon testleri üzerine etkisi araştırılmıştır. Metod: Dört gruba ayrılan bıldırcınlar sırasıyla, %5 ayçekirdeği yağı (SO 1 ), %5 tavuk çevirme yağı (CGO 1 ), %7.5 ayçekirdeği yağı (SO 2 ) and %7.5 tavuk çevirme yağı (CGO 2 ) içeren karma yemlerle beslenmişlerdir. Yem ve su dokuz haftalık deneme boyunca ad libitum olarak verilmiştir. Bulgular: Karma yemlere ilave edilen CGO'nun eritrosit ve karaciğer süperoksit dismütaz (SOD) aktivitesini azalttığı, fakat eritrosit glutatyon peroksidaz (GSH-Px) aktivitesini arttırdığı tespit edilmiştir. Bununla birlikte, karma yemlere...

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Section: Discussioncontrasting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Effects of Dietary Chicken Grill Oil and Sunflower Seed Oil on Blood and Liver Oxidant/Antioxidant Status and Liver Function Tests in Laying Japanese Quails (Coturnix coturnix japonica)

Büyükoğlu¹

2014

Turk J Bioch

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“…The values were used for estimating the GSH / GSSG ratio, an index of glutathione redox status. The glutathione reductase (GR) activity was determined as described by Godin and Garnett (8). Protein concentrations of mitochondrial fractions were determined using a protein assay kit (Bio-Rad, Hercules, CA, USA).…”

mentioning

confidence: 99%

Metformin Protects Against Carbon Tetrachloride Hepatotoxicity in Mice

et al. 2003

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Abstract. In the present study, the hepatoprotective effect of metformin (Met), a dimethylbiguanide anti-hyperglycemic, was examined in a mouse model of liver damage induced by chronic repeated administration of carbon tetrachloride (CCl 4 ) (5 m l / kg, twice a week for 12 weeks). Met, when given orally in drinking water at an estimated daily dose of 25 or 50 mg / kg for 10 weeks starting 2 weeks after CCl 4 challenge, protected against CCl 4 hepatotoxicity. The results indicate that the hepatoprotection afforded by Met treatment at a dose of 25 mg / kg against CCl 4 toxicity may at least in part be mediated by the enhancement of mitochondrial glutathione redox status.

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“…Therefore, it is possible that GPX activity would maintain normal cell functions, whereas catalase would form part of a stress-response mechanism (Janssens et al, 2000). Godin & Garnett (1992) found compensatory relationship between catalase and GPX activities: low GPX activity was combined with high catalase activity.…”

Section: Antioxidant Enzymesmentioning

confidence: 95%