Species of Metarhizium anisopliae complex implicated in human infections: retrospective sequencing study

Nourrisson, Céline; Dupont, Damien; Lavergne, Rose‐Anne; Dorin, Joséphine; Forouzanfar, Faezeh; Denis, Julie; Weeks, Kerry; Joubert, Romain; Chiambaretta, Frédéric; Bourcier, Tristan; Roux, Sandrine; Sénéchal, Agathe; Benaïm, Gilles; Wallon, Martine; Candolfi, Ermanno; Letscher-Bru, Valérie; Poirier, Philippe; Sabou, Marcela

doi:10.1016/j.cmi.2017.05.001

Cited by 26 publications

(4 citation statements)

References 25 publications

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“…There have been few reports of ocular infections secondary to the M. anisopliae complex, 2,6 and only 3 reports of Metarhizium keratitis specifically identify M. robertsii as the causative agent. 7 All of the reported cases of M. anisopliae complex ocular infection were in immunocompetent individuals, as in our patient. The reported mechanisms of fungal infection included contact lens wear and/or exposure to soil during agricultural work.…”

Section: Discussionsupporting

confidence: 52%

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Palazzolo

Kowalski

Nayyar

et al. 2021

Cornea

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This study aimed to describe a case of keratitis secondary to Metarhizium robertsii, a soil-dwelling fungus with typical insect pathogenicity.Methods: A Case report.Results: A 58-year-old man with a ocular history of soft contact lens overwear, poor contact lens hygiene, and ocular exposure to ground well water supplying his house was referred to our university practice for a central corneal ulcer with 40% thinning. Same-day rapid microscopic detection with Giemsa stain identified the presence of many hyphae elements, and he was ultimately diagnosed with M. robertsii keratitis. The patient's course involved severe and progressive corneal thinning that stabilized over a 3-month course of antifungal therapy.Conclusions: Metarhizium robertsii seems more aggressive than other forms of fungal keratitis; therefore, this infection may be watched more closely with the risk for quick progressive corneal thinning, even while on antifungal management.

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Section: Discussionsupporting

confidence: 52%

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Palazzolo

Kowalski

Nayyar

et al. 2021

Cornea

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“…While most of the species discovered in Metarhizium are considered entomopathogenic, studies of their plant-growth promoting and endophytic, rhizosphere or soil-dwelling properties have been increasing ( Hu and St Leger, 2002 , Chad et al., 2014 , Iwanicki et al., 2019 ). As they continue to promote plant health by increasing nutrient absorption through the roots and killing insect pests ( Sasan and Bidochka, 2012 , Liao et al., 2014 , Liao et al., 2017 ) and being used for biological control, reports have also showed Metarhizium implicated in human infections ( Nourrisson et al. 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Revisiting Metarhizium and the description of new species from Thailand

Mongkolsamrit¹,

Khonsanit²,

Thanakitpipattana³

et al. 2020

Studies in Mycology

101

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Over the last two decades the molecular phylogeny and classification of Metarhizium has been widely studied. Despite these efforts to understand this enigmatic genus, the basal lineages in Metarhizium are still poorly resolved. In this study, a phylogenetic framework is reconstructed for the Clavicipitaceae focusing on Metarhizium through increased taxon-sampling using five genomic loci (SSU, LSU, tef, rpb1, rpb 2) and the barcode marker ITS rDNA. Multi-gene phylogenetic analyses and morphological characterisation of green-spored entomopathogenic Metarhizium isolates from Thailand and soil isolates of M. carneum and M. marquandii reveal their ecological, genetic and species diversity. Nineteen new species are recognised in the Metarhizium clade with narrow host ranges: two new species are found in the M. anisopliae complex – M. clavatum on Coleoptera larvae and M. sulphureum on Lepidoptera larvae; four new species are found in the M. flavoviride complex – M. biotecense and M. fusoideum on brown plant hoppers ( Hemiptera ), M. culicidarum on mosquitoes, M. nornnoi on Lepidoptera larvae; three new species M. megapomponiae, M. cicadae, M. niveum occur on cicadas; five new species M. candelabrum, M. cercopidarum, M. ellipsoideum, M. huainamdangense M. ovoidosporum occur on planthoppers, leafhoppers and froghoppers ( Hemiptera ); one new species M. eburneum on Lepidoptera pupae; and four new species M. phuwiangense, M. purpureum, M. purpureonigrum, M. flavum on Coleoptera . Of these 19 new species, seven produce a sexual morph ( M. clavatum, M. eburneum, M. flavum, M. phuwiangense, M. purpureonigrum, M. purpureum, and M. sulphureum ) and asexual morphs are found in the remaining new species and also in M. sulphureum, M. purpureonigrum and M. purpureum. Metarhizium blattodeae, M. koreanum and M. viridulum are new records for Thailand. An alternative neotype for Metarhizium anisopliae is proposed based on multi-gene and 5′ tef analyses showing that CBS 130.71 from Ukraine is more suitable, being from a much closer geographical location to Metchnikoff’s Metarhizium anisopliae. This isolate is distinct from the neotype of Metarhizium anisopliae var. anisopl...

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“…This is notably the case for the hyphomycetes Metarhizium spp. (Nourrisson et al, 2017) and the entomophthorale Conidiobolus coronatus (Chappity and Hallur, 2021;Vilela and Mendoza, 2018). Such cases remain rare and usually only affect vulnerable, e.g.…”

Section: Substitution-based Practicesmentioning

confidence: 99%

Crop protection practices and risks associated with human fungal infectious diseases: a One Health perspective

Ratnadass

Sester

2023

Cah. Agric.

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We review interactions between crop protection practices (developed to control plant pathogens and invertebrate pests) and human fungal infectious diseases. Unlike viral, bacterial and parasitic infections, fungal infections in humans are usually only superficial in healthy individuals, but can become invasive and pose serious risks to immunosuppressed individuals. Although their global impact is less than that of other infectious diseases, human fungal infections still pose serious public health issues. For instance, the use of synthetic agricultural fungicides, particularly the azole class, under conventional intensive, or efficiency improvement-based crop protection practices, is at risk as far as antimicrobial resistance is concerned, due to cases of cross-resistance to clinical azoles used to treat pulmonary aspergillosis, candidiasis and cryptococcocis. In this respect, the One Health approach, originally designed for other types of human pathogens, looks relevant for human pathogenic fungi. Additionally, some entomopathogenic fungi used as biocontrol products against crop pests in a substitution-based approach, may be potentially pathogenic to humans. Very few examples of redesign-based practices (i.e. Agroecological Crop Protection) emerged from our analysis on human fungal diseases. However, discontinuing agricultural azole fungicides (as practiced on organic farms, and which may to some extent be related to the redesign strategy) appears to be the best way to reduce selection pressure and hence the level of azole-resistant human pathogenic fungal strains in the environment.

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Species of Metarhizium anisopliae complex implicated in human infections: retrospective sequencing study

Cited by 26 publications

References 25 publications

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Insect Fungus Metarhizium robertsii Is a Rare Causative Agent of Keratitis

Revisiting Metarhizium and the description of new species from Thailand

Crop protection practices and risks associated with human fungal infectious diseases: a One Health perspective

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