Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain

Garrick, Nancy A.; Murphy, Dennis L.

doi:10.1007/bf00433804

Cited by 159 publications

(43 citation statements)

References 21 publications

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“…These data support previous biochemical results of large differences of MAO characteristics between several animal species as well as in varying tissues (Fowler et al, 1978;Garrick and Murphy, 1980;Fowler and Tipton, 1983). Histochemical comparison of the rat, rabbit and cat showed that the criteria for the distinction of MAO subtypes must be defined for each species (Uchida and Koelle, 1984).…”

Section: Resultssupporting

confidence: 89%

Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil

Konradi

Jellinger

Riederer

et al. 1987

J. Neural Transmission

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A coupled peroxidation technique for localization of monoamine oxidase (MAO-A and MAO-B), applied to post-mortem fixed tissue of the locus coeruleus of the Mongolian gerbil is demonstrated. Tyramine hydrochloride, beta-phenylethylamine and 5-hydroxytryptamine creatinine sulphate were used as substrates, 1-deprenyl and clorgyline served as specific inhibitors. All three substrates stained the neurons of locus coeruleus in the absence of inhibitor. In the presence of 1-deprenyl, tyramine hydrochloride and 5-hydroxytryptamine creatinine sulphate were metabolized, whereas in the presence of clorgyline no reaction with either substrate could be observed. Immunocytochemical staining of tyrosine hydroxylase (TH) was employed as comparison.

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Section: Resultssupporting

confidence: 89%

Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil

Konradi

Jellinger

Riederer

et al. 1987

J. Neural Transmission

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“…The trace amines, tyramine and phenylethyla mine, are metabolized with greatest affini ty by MAO-A and MAO-B, respectively (Murphy 1978). In the adult human brain, MAO-B is the more predominant form (Garrick and Murphy 1980). …”

mentioning

confidence: 99%

Effects of Gestational Exposure to Monoamine Oxidase Inhibitors in Rats: Preliminary Behavioral and Neurochemical Studies

Whitaker‐Azmitia

Zhang

Clarke

1994

Neuropsychopharmacol

103

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Monoamine neurotransmitters are important in the development of the immature mammalian brain, prior to assuming their role as neurotransmitters. The endogenous levels of these transmitters are highly regulated by the enzyme monoamine oxidase (MAO). Thus, any change in this enzyme should have a profound effect on brain development. In order to test this hypothesis, we treated developing rat pups with the monoamine oxidase inhibitors (MAO-Is), dorgyline (MAO-A, 3 mg/kg), and deprenyl (MAO-B, 3 mg/kg) throughout gestation (MAO-I-birth), or throughout gestation and to sacrifice (MAO-I-sac). The animals were analyzed for serotonin and dopamine terminal density, using 3H-paroxetine and 3H-GBR 12935, respectively. Whereas there were no changes in the development of the dopamine system, the serotonin system was severely KEYWORDS: Serotonin; Monoamine oxidase; Monoamine oxidase inhibitors; Deprenyl; Clorgyline; Neurodevelopment; Impulsivity; Hyperactivity; Norrie's disease. affected, particularly in the cortex that showed a significant reduction of innervation at 30 days postnatal. The animals reached all normal development milestones on schedule, and had no changes in measures of anxiety (% light/dark); however, the animals showed increased open field activity and deficits in a passive avoidance paradigm, which may be a measure of impulsivity. The MAO-I-sac animals were severely impaired, showing stereotypic behavior, seizures, and eventually visual impairments. Our results are discussed in terms of relevance to human disease states, such as atypical Norrie's disease, impulsivity, and hyperactivity. As well, our results should be used to caution against the use of MAO-Is in women of child-bearing age.

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“…At the present there are no dear indications about cellular location of MAO-A and how selective reversible MAO-A inhibitors could affect dopamine metabolism formed from exogenous L-dopa in the primate brain. Such studies are clearly essential, since the results obtained from rat brain dopamine metabolism by MAO are not valid for DA metabolism by MAO-A or -B in primate brain (Garrick and Murphy, 1980;Garrick etal., 1984;de Varebeke et al, 1990). Future studies are needed to determine to what extent the cellular localization and compartmentation of MAO-A and -B forms are related to their physiological function with regards to amine neurotransmitter metabolism (Youdim and Finberg, 1991), especially that of dopamine.…”

Section: Interaction Of Dopamine Metabolizing Enzymes With Dopamine Umentioning

confidence: 99%

Dopamine metabolism and neurotransmission in primate brain in relationship to monoamine oxidase A and B inhibition

Youdim

Riederer

1993

J. Neural Transmission

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The "cheese effect", potentiation of sympathomimetic action of indirectly acting amines such as tyramine, the main side effect of irreversible non-selective and selective monoamine oxidase (MAO) A inhibitors, has largely been eliminated in the new generation of reversible selective MAO-A and B and irreversible MAO-B inhibitors. These selective inhibitors are demonstrating unique pharmacology and initial controlled clinical studies are providing evidence to support their action as anti-depressants and anti-Parkinson's disease drugs and possibly as neuroprotectors. Thirty years of experience with non-selective MAO inhibitors has resulted in a better understanding and management of the new generation of MAO inhibitors. Because of their selective action on the specific forms of MAO, which results in selective elevation of brain noradrenaline and serotonin on the one hand and dopamine and phenylethylamine on the other, it is hoped that these drugs will be able to elucidate the functional roles of MAO-A and B subtypes with regards to dopamine metabolism in the human brain.

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Species differences in the deamination of dopamine and other substrates for monoamine oxidase in brain

Cited by 159 publications

References 21 publications

Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil

Histochemistry of MAO-A and MAO-B in the locus coeruleus of the Mongolian gerbil

Effects of Gestational Exposure to Monoamine Oxidase Inhibitors in Rats: Preliminary Behavioral and Neurochemical Studies

Dopamine metabolism and neurotransmission in primate brain in relationship to monoamine oxidase A and B inhibition

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