Maria João Bonifácio, Ana I. Loureiro, Leonel Torrão, Carlos Fernandes-Lopes, Lyndon Wright, Maria João Pinho, Patrício Soares-da-Silva
ABSTRACTThe present study was designed to characterize pharmacodynamic and pharmacokinetic properties of nebicapone in rats and mice. Upon oral administration of nebicapone the extent of mouse liver catechol-O-methyltransferase (COMT) inhibition is half that in the rat.Nebicapone was rapidly absorbed reaching plasma C max within 30 min and being completely eliminated by 8 h. Nebicapone was metabolized mainly by glucuronidation and methylation in both species, but rat had an extra major metabolite, resulting f…
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