Species dependent gentamicin pharmacokinetics and nephrotoxicity in the young horse

Riviere, Jim E.; Coppoc, Gordon L.; Hinsman, E. J.; Carlton, William W.; Traver, D.S.

doi:10.1016/s0272-0590(83)80020-7

Cited by 45 publications

(22 citation statements)

References 41 publications

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“…1983). 1.5-2.5 h in sheep (Wilson et al, 1981;Brown ef al., 1985Brown ef al., , 1986a), 1.8 h in cattle (Haddad et al, 1986), 1.8-3.5 h in horses (Pedersoli et al, 1980;Riviere et al, 1983;Haddad et al, 1985a;Bowman et al, 1986), 1.54.9 h in pigs (Riond & Riviere, 1988). 3.4-3.7 h in chickens and roosters Pedersoli et al, 1990), 1.9 h in owls (Bird ef al., 1983), 0.8-1.8 h in quail, pheasant and cranes (Custer et al, 1979;Riviere ef al., 1990), 2.5 h in eagles (Bird et al, 1983;Riviere et al, 1990), 2.6 h in turkeys , 1.5-2.5 h in human beings (Black et al, 1964;Zaske et al, 1982), and approximately 12 h in catfish (Setzer, 1985).…”

Section: Gen(amuinmentioning

confidence: 99%

“…Volume of the central compartment (V,) is slightly larger than blood volume Riviere et al, 1983;Short et al, 1986;Haddad et al, 1985b;Riond & Riviere, 1988), indicating 'instantaneous' distribution to some limited areas other than the vascular volume. Area-derived volume of distribution (Vd(arer) ) for gentamicin are from 0.16 Vkg in catfish (Setzer, 1985) to 0.32 Vkg in pigs (Riond & Riviere, 1988), with most Vd(area) values near 0.20 Vkg (Table I).…”

Section: Gen(amuinmentioning

confidence: 99%

See 1 more Smart Citation

Comparative pharmacokinetics of aminoglycoside antibiotics

Brown

Riviere

1991

Vet Pharm & Therapeutics

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Section: Gen(amuinmentioning

confidence: 99%

Section: Gen(amuinmentioning

confidence: 99%

Comparative pharmacokinetics of aminoglycoside antibiotics

Brown

Riviere

1991

Vet Pharm & Therapeutics

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“…The systemic effects of Gramnegative sepsis, particularly hypoxia, hypercapnia and azotaemia, are known to alter significantly the pharmacokinetics of amikacin (Pollock et a / . 1977;Riviere et al 1984;Sojka and Brown 1986;Myers et al 1977;Noone et ~1.1974;Mirhij et al 1976). However, consistent clinical monitoring of serum concentrations of amikacin has not been routinely performed in veterinary medicine, and the effects of respiratory and metabolic derangements on pharmacokinetic parameters of amikacin in the serum of critically ill equine neonates have not been extensively studied.…”

Section: Introductionmentioning

confidence: 99%

Effects of hypoxia and azotaemia on the pharmacokinetics of amikacin in neonatal foals

Green

Conlon

Mama

et al. 1992

Equine Veterinary Journal

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Summary The effects of hypoxia and azotaemia on the pharmacokinetics of amikacin were evaluated in 20 full‐term neonatal critically ill foals which required 24‐h supportive care, antibiotics and dextrose‐supplemented polyionic fluids given intravenously, nasal insufflation with oxygen and nutritional supplementation. There was no association between sepsis score or survival and pharmacokinetic parameters. Concurrent hypoxia and azotaemia were associated with significantly decreased clearance and increased peak and trough serum concentrations of amikacin; however, peaks or troughs did not exceed toxic values. Derangements in serum peak, trough and clearance values, which were present on admission, persisted over the 6‐day duration of this study. Daily monitoring of serum amikacin concentration revealed a tendency to underdose (particularly in foals receiving aggressive fluid therapy), which necessitated increasing the dose/kg body weight (9–12 mg/kg) and increasing the dose interval (10–12 h) in 40% (8/20) of the cases, so that blood concentrations of amikacin could be maintained within the target range of 3–15 μg/ml. Amikacin‐induced nephrotoxicity was not indicated by conventional laboratory testing, nor was it strongly suspected after examination of post mortem lesions.

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“…12,13 Where C max and C min are peak and trough serum concentrations, respectively, while Δt is the time between measurements of C max and C min . The plasma half-lives of elimination (t½β) were obtained from t½β=0.693/β, where β is the average of the values obtained on days 1, 3, and 5 for each group.…”

Section: Pharmacokinetic Analysismentioning

confidence: 99%